Justin A. MacDonald - Publications

Affiliations: 
1993-1998 Biology Carleton University, Ottawa, Canada 

72 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Al-Ghabkari A, Carlson DA, Haystead TAJ, MacDonald JA. Cooperative involvement of zipper-interacting protein kinase (ZIPK) and the dual-specificity cell-division cycle 14A phosphatase (CDC14A) in vascular smooth muscle cell migration. Biorxiv : the Preprint Server For Biology. PMID 38496458 DOI: 10.1101/2024.03.06.583600  0.792
2023 Turner SR, Al-Ghabkari A, Carlson DA, Chappellaz M, Sutherland C, Haystead TAJ, Cole WC, MacDonald JA. Death-associated protein kinase 3 regulates the myogenic reactivity of cerebral arteries. Experimental Physiology. PMID 37084168 DOI: 10.1113/EP090631  0.752
2022 Murali M, Turner SR, Belke DD, Cole WC, MacDonald JA. Smoothelin-like 1 knockout mice display sex-dependent alterations in blood flow and cardiac function. Canadian Journal of Physiology and Pharmacology. PMID 36342379 DOI: 10.1139/cjpp-2022-0172  0.586
2019 Deng JT, Bhaidani S, Sutherland C, MacDonald JA, Walsh MP. Rho-associated kinase and zipper-interacting protein kinase, but not myosin light chain kinase, are involved in the regulation of myosin phosphorylation in serum-stimulated human arterial smooth muscle cells. Plos One. 14: e0226406. PMID 31834925 DOI: 10.1371/Journal.Pone.0226406  0.411
2019 Sandall CF, MacDonald JA. Effects of phosphorylation on the NLRP3 inflammasome. Archives of Biochemistry and Biophysics. PMID 30844378 DOI: 10.1016/j.abb.2019.02.020  0.4
2019 Turner SR, Chappellaz M, Popowich B, Wooldridge AA, Haystead TAJ, Cole WC, MacDonald JA. Smoothelin-like 1 deletion enhances myogenic reactivity of mesenteric arteries with alterations in PKC and myosin phosphatase signaling. Scientific Reports. 9: 481. PMID 30679490 DOI: 10.1038/S41598-018-36564-0  0.706
2018 MacDonald JA, Ulke-Lemée A, Chappellaz M, Segboer H. Tools and protocol for quantification of myosin phosphorylation with MRM-MS. Methodsx. 5: 466-474. PMID 30622916 DOI: 10.1016/j.mex.2018.05.004  0.323
2018 Al-Ghabkari A, Moffat LD, Walsh MP, MacDonald JA. Validation of chemical genetics for the study of zipper-interacting protein kinase signaling. Proteins. PMID 30381843 DOI: 10.1002/Prot.25607  0.774
2018 Carlson DA, Singer MR, Sutherland C, Redondo C, Alexander LT, Hughes PF, Knapp S, Gurley SB, Sparks MA, MacDonald JA, Haystead TAJ. Targeting Pim Kinases and DAPK3 to Control Hypertension. Cell Chemical Biology. PMID 30033129 DOI: 10.1016/J.Chembiol.2018.06.006  0.397
2018 Walsh MP, MacDonald JA. Regulation of Smooth Muscle Myosin Light Chain Phosphatase by Multi-site Phosphorylation of the Myosin Targeting Subunit, MYPT1. Cardiovascular & Hematological Disorders Drug Targets. PMID 29577868 DOI: 10.2174/1871529X18666180326120638  0.463
2018 Chappellaz M, Segboer H, Ulke-Lemée A, Sutherland C, Chen HM, MacDonald JA. Quantitation of myosin regulatory light chain phosphorylation in biological samples with multiple reaction monitoring mass spectrometry. Biochimica Et Biophysica Acta. PMID 29567090 DOI: 10.1016/j.bbapap.2018.03.008  0.343
2018 Murali M, MacDonald JA. Smoothelins and the Control of Muscle Contractility. Advances in Pharmacology (San Diego, Calif.). 81: 39-78. PMID 29310803 DOI: 10.1016/bs.apha.2017.10.001  0.407
2017 Bátori R, Kumar S, Bordán Z, Cherian-Shaw M, Kovács-Kása A, MacDonald JA, Fulton DJR, Erdődi F, Verin AD. Differential mechanisms of adenosine- and ATPγS-induced microvascular endothelial barrier strengthening. Journal of Cellular Physiology. PMID 29271489 DOI: 10.1002/jcp.26419  0.386
2017 Ulke-Lemée A, Sun DH, Ishida H, Vogel HJ, MacDonald JA. Binding of smoothelin-like 1 to tropomyosin and calmodulin is mutually exclusive and regulated by phosphorylation. Bmc Biochemistry. 18: 5. PMID 28320308 DOI: 10.1186/S12858-017-0080-6  0.495
2016 Al-Ghabkari A, Deng JT, McDonald PC, Dedhar S, Alshehri M, Walsh MP, MacDonald JA. A novel inhibitory effect of oxazol-5-one compounds on ROCKII signaling in human coronary artery vascular smooth muscle cells. Scientific Reports. 6: 32118. PMID 27573465 DOI: 10.1038/Srep32118  0.798
2016 Sutherland C, MacDonald JA, Walsh MP. Analysis of phosphorylation of the myosin-targeting subunit of myosin light chain phosphatase by Phos-tag SDS-PAGE. American Journal of Physiology. Cell Physiology. 310: C681-91. PMID 26864694 DOI: 10.1152/Ajpcell.00327.2015  0.465
2016 Sutherland C, MacDonald JA, Walsh MP. Analysis of phosphorylation of the myosin-targeting subunit of myosin light chain phosphatase by Phos-tag SDS-PAGE American Journal of Physiology - Cell Physiology. 310: C681-C691. DOI: 10.1152/ajpcell.00327.2015  0.464
2015 MacDonald JA, Sutherland C, Carlson DA, Bhaidani S, Al-Ghabkari A, Sward K, Haystead TA, Walsh MP. A Small Molecule Pyrazolo[3,4-d]pyrimidinone Inhibitor of Zipper-Interacting Protein Kinase Suppresses Calcium Sensitization of Vascular Smooth Muscle. Molecular Pharmacology. PMID 26464323 DOI: 10.1124/Mol.115.100529  0.8
2015 Ulke-Lemée A, Turner SR, MacDonald JA. In situ Analysis of Smoothelin-Like 1 and Calmodulin Interactions in Smooth Muscle Cells by Proximity Ligation. Journal of Cellular Biochemistry. PMID 25923522 DOI: 10.1002/jcb.25215  0.684
2015 MacDonald JA. A tale of two threonines: myosin phosphatase inhibition and calcium sensitization of smooth muscle. The Journal of Physiology. 593: 487-8. PMID 25774393  0.327
2015 Ihara E, Yu Q, Chappellaz M, MacDonald JA. ERK and p38MAPK pathways regulate myosin light chain phosphatase and contribute to Ca2+ sensitization of intestinal smooth muscle contraction. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society. 27: 135-46. PMID 25557225 DOI: 10.1111/nmo.12491  0.487
2015 Macdonald JA. A tale of two threonines: Myosin phosphatase inhibition and calcium sensitization of smooth muscle Journal of Physiology. 593: 487-488. DOI: 10.1113/jphysiol.2014.270019  0.327
2014 Turner SR, MacDonald JA. Novel contributions of the smoothelin-like 1 protein in vascular smooth muscle contraction and its potential involvement in myogenic tone. Microcirculation (New York, N.Y. : 1994). 21: 249-58. PMID 24267201 DOI: 10.1111/micc.12108  0.718
2013 Carlson DA, Franke AS, Weitzel DH, Speer BL, Hughes PF, Hagerty L, Fortner CN, Veal JM, Barta TE, Zieba BJ, Somlyo AV, Sutherland C, Deng JT, Walsh MP, MacDonald JA, et al. Fluorescence linked enzyme chemoproteomic strategy for discovery of a potent and selective DAPK1 and ZIPK inhibitor. Acs Chemical Biology. 8: 2715-23. PMID 24070067 DOI: 10.1021/Cb400407C  0.504
2013 MacDonald JA, Moffat LD, Al-Ghabkari A, Sutherland C, Walsh MP. Prostate-apoptosis response-4 phosphorylation in vascular smooth muscle. Archives of Biochemistry and Biophysics. 535: 84-90. PMID 23219599 DOI: 10.1016/J.Abb.2012.11.009  0.792
2012 Grassie ME, Sutherland C, Ulke-Lemée A, Chappellaz M, Kiss E, Walsh MP, MacDonald JA. Cross-talk between Rho-associated kinase and cyclic nucleotide-dependent kinase signaling pathways in the regulation of smooth muscle myosin light chain phosphatase. The Journal of Biological Chemistry. 287: 36356-69. PMID 22948155 DOI: 10.1074/jbc.M112.398479  0.465
2012 MacDonald JA, Ishida H, Butler EI, Ulke-Lemée A, Chappellaz M, Tulk SE, Chik JK, Vogel HJ. Intrinsically disordered N-terminus of calponin homology-associated smooth muscle protein (CHASM) interacts with the calponin homology domain to enable tropomyosin binding. Biochemistry. 51: 2694-705. PMID 22424482 DOI: 10.1021/Bi2019018  0.34
2012 Ihara E, Chappellaz M, Turner SR, MacDonald JA. The contribution of protein kinase C and CPI-17 signaling pathways to hypercontractility in murine experimental colitis. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society. 24: e15-26. PMID 22093175 DOI: 10.1111/j.1365-2982.2011.01821.x  0.456
2011 Moffat LD, Brown SB, Grassie ME, Ulke-Lemée A, Williamson LM, Walsh MP, MacDonald JA. Chemical genetics of zipper-interacting protein kinase reveal myosin light chain as a bona fide substrate in permeabilized arterial smooth muscle. The Journal of Biological Chemistry. 286: 36978-91. PMID 21880706 DOI: 10.1074/Jbc.M111.257949  0.508
2011 Ihara E, Akiho H, Nakamura K, Turner SR, Macdonald JA. MAPKs represent novel therapeutic targets for gastrointestinal motility disorders. World Journal of Gastrointestinal Pathophysiology. 2: 19-25. PMID 21607162 DOI: 10.4291/wjgp.v2.i2.19  0.662
2011 Ulke-Lemée A, Turner SR, Mughal SH, Borman MA, Winkfein RJ, MacDonald JA. Mapping and functional characterization of the murine smoothelin-like 1 promoter. Bmc Molecular Biology. 12: 10. PMID 21352594 DOI: 10.1186/1471-2199-12-10  0.627
2011 Grassie ME, Moffat LD, Walsh MP, MacDonald JA. The myosin phosphatase targeting protein (MYPT) family: a regulated mechanism for achieving substrate specificity of the catalytic subunit of protein phosphatase type 1δ. Archives of Biochemistry and Biophysics. 510: 147-59. PMID 21291858 DOI: 10.1016/J.Abb.2011.01.018  0.457
2010 Ulke-Lemée A, MacDonald JA. Opportunities to Target Specific Contractile Abnormalities with Smooth Muscle Protein Kinase Inhibitors. Pharmaceuticals (Basel, Switzerland). 3: 1739-1760. PMID 27713327 DOI: 10.3390/ph3061739  0.518
2010 Hirota SA, Fines K, Ng J, Traboulsi D, Lee J, Ihara E, Li Y, Willmore WG, Chung D, Scully MM, Louie T, Medlicott S, Lejeune M, Chadee K, Armstrong G, ... ... MacDonald JA, et al. Hypoxia-inducible factor signaling provides protection in Clostridium difficile-induced intestinal injury. Gastroenterology. 139: 259-69.e3. PMID 20347817 DOI: 10.1053/J.Gastro.2010.03.045  0.506
2010 Ulke-Lemée A, MacDonald JA. Opportunities to target specific contractile abnormalities with smooth muscle protein kinase inhibitors Pharmaceuticals. 3: 1739-1760. DOI: 10.3390/ph3061739  0.518
2009 Ihara E, Moffat L, Borman MA, Amon JE, Walsh MP, MacDonald JA. Ca2+-independent contraction of longitudinal ileal smooth muscle is potentiated by a zipper-interacting protein kinase pseudosubstrate peptide. American Journal of Physiology. Gastrointestinal and Liver Physiology. 297: G361-70. PMID 19541925 DOI: 10.1152/Ajpgi.00112.2009  0.537
2009 MacDonald JA, Degenhardt T, Baynes JW, Storey KB. Glycation of wood frog (Rana sylvatica) hemoglobin and blood proteins: in vivo and in vitro studies. Cryobiology. 59: 223-5. PMID 19540217 DOI: 10.1016/J.Cryobiol.2009.06.008  0.326
2009 Borman MA, Freed TA, Haystead TA, Macdonald JA. The role of the calponin homology domain of smoothelin-like 1 (SMTNL1) in myosin phosphatase inhibition and smooth muscle contraction. Molecular and Cellular Biochemistry. 327: 93-100. PMID 19219534 DOI: 10.1007/S11010-009-0047-Z  0.371
2009 Ihara E, Beck PL, Chappellaz M, Wong J, Medlicott SA, MacDonald JA. Mitogen-activated protein kinase pathways contribute to hypercontractility and increased Ca2+ sensitization in murine experimental colitis. Molecular Pharmacology. 75: 1031-41. PMID 19190174 DOI: 10.1124/mol.108.049858  0.411
2008 MacDonald JA. Smooth muscle phenotypic plasticity in mechanical obstruction of the small intestine Neurogastroenterology and Motility. 20: 737-740. PMID 18557891 DOI: 10.1111/j.1365-2982.2008.01148.x  0.309
2008 Uhrig RG, O'Leary B, Spang HE, MacDonald JA, She YM, Plaxton WC. Coimmunopurification of phosphorylated bacterial- and plant-type phosphoenolpyruvate carboxylases with the plastidial pyruvate dehydrogenase complex from developing castor oil seeds. Plant Physiology. 146: 1346-57. PMID 18184736 DOI: 10.1104/Pp.107.110361  0.524
2008 Ihara E, Hirota SA, Beck PL, MacDonald JA. S1729 Upregulation of HIF-1α Is Associated with Augmented Rho-Kinase-Mediated Contraction of Ileal Smooth Muscle Following Exposure to Clostridium difficile Toxins in a Mouse Ileal Loop Model Gastroenterology. 134: A-258. DOI: 10.1016/S0016-5085(08)61200-7  0.383
2007 MacDonald JA, Storey KB. The effect of hibernation on protein phosphatases from ground squirrel organs Archives of Biochemistry and Biophysics. 468: 234-243. PMID 17964276 DOI: 10.1016/j.abb.2007.10.005  0.482
2007 Ihara E, Moffat L, Ostrander J, Walsh MP, MacDonald JA. Characterization of protein kinase pathways responsible for Ca2+ sensitization in rat ileal longitudinal smooth muscle. American Journal of Physiology. Gastrointestinal and Liver Physiology. 293: G699-710. PMID 17656444 DOI: 10.1152/Ajpgi.00214.2007  0.53
2007 Ihara E, MacDonald JA. The regulation of smooth muscle contractility by zipper-interacting protein kinase Canadian Journal of Physiology and Pharmacology. 85: 79-87. PMID 17487247 DOI: 10.1139/Y06-103  0.543
2007 Borman MA, MacDonald JA, Haystead TA. Staurosporine inhibition of zipper-interacting protein kinase contractile effects in gastrointestinal smooth muscle. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 85: 111-20. PMID 17464351 DOI: 10.1139/o06-209  0.52
2007 Ihara E, Edwards E, Borman MA, Wilson DP, Walsh MP, MacDonald JA. Inhibition of zipper-interacting protein kinase function in smooth muscle by a myosin light chain kinase pseudosubstrate peptide. American Journal of Physiology. Cell Physiology. 292: C1951-9. PMID 17215325 DOI: 10.1152/Ajpcell.00434.2006  0.459
2007 Borman M, MacDonald J. Purification of smooth muscle myosin phosphatase using a thiophosphorylated myosin light-chain-affinity resin. Methods in Molecular Biology (Clifton, N.J.). 365: 225-33. PMID 17200565 DOI: 10.1385/1-59745-267-X:225  0.417
2007 MacDonald JA. 68. Protein kinases & phosphatases - role in natural cryoprotection Cryobiology. 55: 346-347. DOI: 10.1016/j.cryobiol.2007.10.071  0.387
2006 Bridges D, MacDonald JA, Wadzinski B, Moorhead GB. Identification and characterization of D-AKAP1 as a major adipocyte PKA and PP1 binding protein. Biochemical and Biophysical Research Communications. 346: 351-7. PMID 16756943 DOI: 10.1016/J.Bbrc.2006.05.138  0.342
2006 MacDonald JA, Storey KB. Identification of a 115 kDa MAP-kinase activated by freezing and anoxic stresses in the marine periwinkle, Littorina littorea Archives of Biochemistry and Biophysics. 450: 208-214. PMID 16620767 DOI: 10.1016/j.abb.2006.03.015  0.587
2005 Wilson DP, Sutherland C, Borman MA, Deng JT, Macdonald JA, Walsh MP. Integrin-linked kinase is responsible for Ca2+-independent myosin diphosphorylation and contraction of vascular smooth muscle. The Biochemical Journal. 392: 641-8. PMID 16201970 DOI: 10.1042/Bj20051173  0.513
2005 MacDonald JA, Storey KB. Temperature and phosphate effects on allosteric phenomena of phosphofructokinase from a hibernating ground squirrel (Spermophilus lateralis) Febs Journal. 272: 120-128. PMID 15634337 DOI: 10.1111/j.1432-1033.2004.04388.x  0.411
2005 MacDonald JA, Storey KB. Mitogen-activated protein kinases and selected downstream targets display organ-specific responses in the hibernating ground squirrel International Journal of Biochemistry and Cell Biology. 37: 679-691. PMID 15618024 DOI: 10.1016/j.biocel.2004.05.023  0.559
2004 Zhao M, Sutherland C, Wilson DP, Deng J, MacDonald JA, Walsh MP. Identification of the linker histone H1 as a protein kinase Cε-binding protein in vascular smooth muscle Biochemistry and Cell Biology. 82: 538-546. PMID 15499382 DOI: 10.1139/O04-053  0.323
2004 Borman MA, MacDonald JA, Haystead TA. Modulation of smooth muscle contractility by CHASM, a novel member of the smoothelin family of proteins. Febs Letters. 573: 207-13. PMID 15327999 DOI: 10.1016/J.Febslet.2004.08.002  0.475
2004 Wooldridge AA, MacDonald JA, Erdodi F, Ma C, Borman MA, Hartshorne DJ, Haystead TA. Smooth muscle phosphatase is regulated in vivo by exclusion of phosphorylation of threonine 696 of MYPT1 by phosphorylation of Serine 695 in response to cyclic nucleotides. The Journal of Biological Chemistry. 279: 34496-504. PMID 15194681 DOI: 10.1074/Jbc.M405957200  0.501
2004 Jones JC, Phatnani HP, Haystead TA, MacDonald JA, Alam SM, Greenleaf AL. C-terminal repeat domain kinase I phosphorylates Ser2 and Ser5 of RNA polymerase II C-terminal domain repeats. The Journal of Biological Chemistry. 279: 24957-64. PMID 15047695 DOI: 10.1074/Jbc.M402218200  0.31
2003 Corcoran EE, Joseph JD, MacDonald JA, Kane CD, Haystead TA, Means AR. Proteomic analysis of calcium/calmodulin-dependent protein kinase I and IV in vitro substrates reveals distinct catalytic preferences. The Journal of Biological Chemistry. 278: 10516-22. PMID 12538590 DOI: 10.1074/Jbc.M210642200  0.356
2002 MacDonald JA, Storey KB. Purification and characterization of fructose bisphosphate aldolase from the ground squirrel, Spermophilus lateralis: Enzyme role in mammalian hibernation Archives of Biochemistry and Biophysics. 408: 279-285. PMID 12464282 DOI: 10.1016/S0003-9861(02)00579-9  0.35
2002 Murányi A, MacDonald JA, Deng JT, Wilson DP, Haystead TA, Walsh MP, Erdodi F, Kiss E, Wu Y, Hartshorne DJ. Phosphorylation of the myosin phosphatase target subunit by integrin-linked kinase. The Biochemical Journal. 366: 211-6. PMID 12030846 DOI: 10.1042/Bj20020401  0.406
2002 Borman MA, MacDonald JA, Murányi A, Hartshorne DJ, Haystead TA. Smooth muscle myosin phosphatase-associated kinase induces Ca2+ sensitization via myosin phosphatase inhibition. The Journal of Biological Chemistry. 277: 23441-6. PMID 11976330 DOI: 10.1074/Jbc.M201597200  0.448
2002 MacDonald JA, Storey KB. Protein phosphatase type-1 from skeletal muscle of the freeze-tolerant wood frog Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology. 131: 27-36. PMID 11742755 DOI: 10.1016/S1096-4959(01)00477-8  0.479
2001 MacDonald JA, Storey KB. Reassessment of the cold-labile nature of phosphofructokinase from a hibernating ground squirrel Molecular and Cellular Biochemistry. 225: 51-57. PMID 11716364 DOI: 10.1023/A:1012264723657  0.373
2001 Walker LA, MacDonald JA, Liu X, Nakamoto RK, Haystead TAJ, Somlyo AV, Somlyo AP. Site-specific Phosphorylation and Point Mutations of Telokin Modulate Its Ca2+-desensitizing Effect in Smooth Muscle Journal of Biological Chemistry. 276: 24519-24524. PMID 11346659 DOI: 10.1074/Jbc.M103560200  0.335
2001 MacDonald JA, Eto M, Borman MA, Brautigan DL, Haystead TA. Dual Ser and Thr phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by MYPT-associated kinase. Febs Letters. 493: 91-4. PMID 11287002 DOI: 10.1016/S0014-5793(01)02277-3  0.375
2001 MacDonald JA, Borman MA, Murányi A, Somlyo AV, Hartshorne DJ, Haystead TAJ. Identification of the endogenous smooth muscle myosin phosphatase-associated kinase Proceedings of the National Academy of Sciences of the United States of America. 98: 2419-2424. PMID 11226254 DOI: 10.1073/Pnas.041331498  0.464
2000 MacDonald JA, Walker LA, Nakamoto RK, Gorenne I, Somlyo AV, Somlyo AP, Haystead TAJ. Phosphorylation of telokin by cyclic nucleotide kinases and the identification of in vivo phosphorylation sites in smooth muscle Febs Letters. 479: 83-88. PMID 10981712 DOI: 10.1016/S0014-5793(00)01884-6  0.495
2000 Stewart JM, Claude JF, MacDonald JA, Storey KB. The muscle fatty acid binding protein of spadefoot toad (Scaphiopus couchii). Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology. 125: 347-57. PMID 10818268 DOI: 10.1016/S0305-0491(99)00188-1  0.368
1999 MacDonald JA, Storey KB. Regulation of ground squirrel Na+K+-ATPase activity by reversible phosphorylation during hibernation Biochemical and Biophysical Research Communications. 254: 424-429. PMID 9918854 DOI: 10.1006/bbrc.1998.9960  0.535
1999 MacDonald JA, Storey KB. Cyclic AMP-dependent protein kinase: Role in anoxia and freezing tolerance of the marine periwinkle Littrorina littorea Marine Biology. 133: 193-203. DOI: 10.1007/s002270050458  0.469
1998 MacDonald JA, Storey KB. cAMP-dependent protein kinase from brown adipose tissue: Temperature effects on kinetic properties and enzyme role in hibernating ground squirrels Journal of Comparative Physiology - B Biochemical, Systemic, and Environmental Physiology. 168: 513-525. PMID 9810716 DOI: 10.1007/s003600050172  0.407
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