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Luis Miguel GARCIA-SEGURA, PhD - Publications

Affiliations: 
CSIC Cajal Institute, Madrid, Spain 
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219 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Marraudino M, Carrillo B, Bonaldo B, Llorente R, Campioli E, Garate I, Pinos H, Garcia-Segura LM, Collado P, Grassi D. G protein-coupled estrogen receptor immunoreactivity in the rat hypothalamus is widely distributed in neurons, astrocytes and oligodendrocytes, fluctuates during the estrous cycle and is sexually dimorphic. Neuroendocrinology. PMID 32570260 DOI: 10.1159/000509583  0.364
2020 Crespo-Castrillo A, Garcia-Segura LM, Arevalo MA. The synthetic steroid tibolone exerts sex-specific regulation of astrocyte phagocytosis under basal conditions and after an inflammatory challenge. Journal of Neuroinflammation. 17: 37. PMID 31992325 DOI: 10.1186/s12974-020-1719-6  0.384
2019 Chowen JA, Garcia-Segura LM. Microglia, neurodegeneration and loss of neuroendocrine control. Progress in Neurobiology. 184: 101720. PMID 31715222 DOI: 10.1016/j.pneurobio.2019.101720  0.352
2019 Azcoitia I, Barreto GE, Garcia-Segura LM. Molecular mechanisms and cellular events involved in the neuroprotective actions of estradiol. Analysis of sex differences. Frontiers in Neuroendocrinology. 100787. PMID 31513774 DOI: 10.1016/j.yfrne.2019.100787  0.677
2019 Marraudino M, Farinetti A, Arevalo MA, Gotti S, Panzica G, Garcia-Segura LM. Sexually Dimorphic Effect of Genistein on Hypothalamic Neuronal Differentiation in Vitro. International Journal of Molecular Sciences. 20. PMID 31109056 DOI: 10.3390/ijms20102465  0.36
2019 Acaz-Fonseca E, Ortiz-Rodriguez A, Azcoitia I, Garcia-Segura LM, Arevalo MA. Notch signaling in astrocytes mediates their morphological response to an inflammatory challenge. Cell Death Discovery. 5: 85. PMID 30962951 DOI: 10.1038/s41420-019-0166-6  0.59
2018 Martin-Jiménez C, Gaitán-Vaca D, Areiza N, Echeverria V, Ashraf G, González J, Sahebkar A, Garcia-Segura LM, Barreto GE. Astrocytes mediate protective actions of estrogenic compounds after traumatic brain injury. Neuroendocrinology. PMID 30391959 DOI: 10.1159/000495078  0.343
2018 Brocca ME, Garcia-Segura LM. Non-reproductive Functions of Aromatase in the Central Nervous System Under Physiological and Pathological Conditions. Cellular and Molecular Neurobiology. PMID 30084008 DOI: 10.1007/s10571-018-0607-4  0.349
2018 Giatti S, Garcia-Segura LM, Barreto GE, Melcangi RC. Neuroactive steroids, neurosteroidogenesis and sex. Progress in Neurobiology. 176: 1-17. PMID 29981391 DOI: 10.1016/j.pneurobio.2018.06.007  0.32
2018 Saraceno GE, Bellini MJ, Garcia-Segura LM, Capani F. Estradiol Activates PI3K/Akt/GSK3 Pathway Under Chronic Neurodegenerative Conditions Triggered by Perinatal Asphyxia. Frontiers in Pharmacology. 9: 335. PMID 29686616 DOI: 10.3389/fphar.2018.00335  0.311
2018 Crespo-Castrillo A, Yanguas-Casás N, Arevalo MA, Azcoitia I, Barreto GE, Garcia-Segura LM. The Synthetic Steroid Tibolone Decreases Reactive Gliosis and Neuronal Death in the Cerebral Cortex of Female Mice After a Stab Wound Injury. Molecular Neurobiology. PMID 29582398 DOI: 10.1007/s12035-018-1008-x  0.659
2018 Yanguas-Casás N, Crespo-Castrillo A, de Ceballos ML, Chowen JA, Azcoitia I, Arevalo MA, Garcia-Segura LM. Sex differences in the phagocytic and migratory activity of microglia and their impairment by palmitic acid. Glia. 66: 522-537. PMID 29139169 DOI: 10.1002/glia.23263  0.589
2018 Azcoitia I, Arevalo MA, Garcia-Segura LM. Neural-derived estradiol regulates brain plasticity. Journal of Chemical Neuroanatomy. 89: 53-59. PMID 28414121 DOI: 10.1016/j.jchemneu.2017.04.004  0.663
2017 Cambiasso MJ, Cisternas CD, Ruiz-Palmero I, Scerbo MJ, Arevalo MA, Azcoitia I, Garcia-Segura LM. Interaction of sex chromosome complement, gonadal hormones and neuronal steroid synthesis on the sexual differentiation of mammalian neurons. Journal of Neurogenetics. 31: 300-306. PMID 29078716 DOI: 10.1080/01677063.2017.1390572  0.645
2017 Cisternas CD, Garcia-Segura LM, Cambiasso MJ. Hormonal and genetic factors interact to control aromatase expression in the developing brain. Journal of Neuroendocrinology. PMID 28891264 DOI: 10.1111/jne.12535  0.313
2017 Cisternas CD, Cabrera Zapata LE, Arevalo MA, Garcia-Segura LM, Cambiasso MJ. Regulation of aromatase expression in the anterior amygdala of the developing mouse brain depends on ERβ and sex chromosome complement. Scientific Reports. 7: 5320. PMID 28706210 DOI: 10.1038/s41598-017-05658-6  0.33
2016 Arbo BD, Vieira-Marques C, Ruiz-Palmero I, Ortiz-Rodriguez A, Arevalo MA, Garcia-Segura LM, Ribeiro MF. 4'-Chlorodiazepam modulates the development of primary hippocampal neurons in a sex-dependent manner. Neuroscience Letters. 639: 98-102. PMID 28041963 DOI: 10.1016/j.neulet.2016.12.067  0.303
2016 Baez E, Echeverria V, Cabezas R, Ávila-Rodriguez M, Garcia-Segura LM, Barreto GE. Protection by Neuroglobin Expression in Brain Pathologies. Frontiers in Neurology. 7: 146. PMID 27672379 DOI: 10.3389/fneur.2016.00146  0.348
2016 Pietranera L, Correa J, Brocca ME, Roig P, Lima A, Di Giorgio N, Garcia-Segura LM, De Nicola AF. Selective oestrogen receptor agonists rescued hippocampus parameters in male spontaneously hypertensive rats. Journal of Neuroendocrinology. PMID 27517478 DOI: 10.1111/jne.12415  0.333
2016 Acaz-Fonseca E, Avila-Rodriguez M, Garcia-Segura LM, Barreto GE. Regulation of astroglia by gonadal steroid hormones under physiological and pathological conditions. Progress in Neurobiology. PMID 27283249 DOI: 10.1016/j.pneurobio.2016.06.002  0.373
2016 Lopez-Rodriguez AB, Mela V, Acaz-Fonseca E, Garcia-Segura LM, Viveros MP. CB2 cannabinoid receptor is involved in the anti-inflammatory effects of leptin in a model of traumatic brain injury. Experimental Neurology. PMID 27006282 DOI: 10.1016/j.expneurol.2016.03.018  0.301
2015 Mitro N, Cermenati G, Audano M, Giatti S, D'Antonio M, Fabiani ED, Crestani M, Saez E, Azcoitia I, Cavaletti G, Garcia-Segura LM, Melcangi RC, Caruso D. The lipogenic regulator Sterol Regulatory Element Binding Factor-1c is required to maintain peripheral nerve structure and function. Springerplus. 4: L45. PMID 27386207 DOI: 10.1186/2193-1801-4-S1-L45  0.566
2015 Giatti S, Foglio B, Romano S, Pesaresi M, Panzica G, Garcia-Segura LM, Caruso D, Melcangi RC. Effects of Subchronic Finasteride Treatment and Withdrawal on Neuroactive Steroid Levels and their Receptors in the Male Rat Brain. Neuroendocrinology. PMID 26646518 DOI: 10.1159/000442982  0.333
2015 Arevalo MA, Azcoitia I, Gonzalez-Burgos I, Garcia-Segura LM. Signaling mechanisms mediating the regulation of synaptic plasticity and memory by estradiol. Hormones and Behavior. PMID 25921586 DOI: 10.1016/J.Yhbeh.2015.04.016  0.642
2015 Zancan M, Dall'Oglio A, Sarzenski TM, Maher MI, Garcia-Segura LM, Rasia-Filho AA. Glial and axonal perikaryal coverage and somatic spines in the posterodorsal medial amygdala of male and cycling female rats. The Journal of Comparative Neurology. PMID 25823984 DOI: 10.1002/cne.23782  0.301
2015 Cermenati G, Audano M, Giatti S, Carozzi V, Porretta-Serapiglia C, Pettinato E, Ferri C, D'Antonio M, De Fabiani E, Crestani M, Scurati S, Saez E, Azcoitia I, Cavaletti G, Garcia-Segura LM, et al. Lack of sterol regulatory element binding factor-1c imposes glial Fatty Acid utilization leading to peripheral neuropathy. Cell Metabolism. 21: 571-83. PMID 25817536 DOI: 10.1016/J.Cmet.2015.02.016  0.566
2015 Arevalo MA, Azcoitia I, Garcia-Segura LM. The neuroprotective actions of oestradiol and oestrogen receptors. Nature Reviews. Neuroscience. 16: 17-29. PMID 25423896 DOI: 10.1038/nrn3856  0.68
2015 Pietranera L, Brocca ME, Roig P, Lima A, Garcia-Segura LM, De Nicola AF. Estrogens are neuroprotective factors for hypertensive encephalopathy. The Journal of Steroid Biochemistry and Molecular Biology. 146: 15-25. PMID 24736028 DOI: 10.1016/j.jsbmb.2014.04.001  0.365
2015 Lopez-Rodriguez AB, Siopi E, Finn DP, Marchand-Leroux C, Garcia-Segura LM, Jafarian-Tehrani M, Viveros MP. CB1 and CB2 cannabinoid receptor antagonists prevent minocycline-induced neuroprotection following traumatic brain injury in mice. Cerebral Cortex (New York, N.Y. : 1991). 25: 35-45. PMID 23960212 DOI: 10.1093/cercor/bht202  0.309
2015 Mitro N, Cermenati G, Audano M, Giatti S, D’Antonio M, De Fabiani E, Crestani M, Saez E, Azcoitia I, Cavaletti G, Garcia-Segura LM, Melcangi RC, Caruso D. The lipogenic regulator Sterol Regulatory Element Binding Factor-1c is required to maintain peripheral nerve structure and function Springerplus. 4: 1-32. DOI: 10.1186/2193-1801-4-S1-L45  0.542
2014 Barreto GE, Santos-Galindo M, Garcia-Segura LM. Selective estrogen receptor modulators regulate reactive microglia after penetrating brain injury. Frontiers in Aging Neuroscience. 6: 132. PMID 24999330 DOI: 10.3389/fnagi.2014.00132  0.341
2014 Mitro N, Cermenati G, Brioschi E, Abbiati F, Audano M, Giatti S, Crestani M, De Fabiani E, Azcoitia I, Garcia-Segura LM, Caruso D, Melcangi RC. Neuroactive steroid treatment modulates myelin lipid profile in diabetic peripheral neuropathy. The Journal of Steroid Biochemistry and Molecular Biology. 143: 115-21. PMID 24607810 DOI: 10.1016/j.jsbmb.2014.02.015  0.571
2014 Acaz-Fonseca E, Sanchez-Gonzalez R, Azcoitia I, Arevalo MA, Garcia-Segura LM. Role of astrocytes in the neuroprotective actions of 17β-estradiol and selective estrogen receptor modulators. Molecular and Cellular Endocrinology. 389: 48-57. PMID 24444786 DOI: 10.1016/j.mce.2014.01.009  0.705
2014 Melcangi RC, Giatti S, Calabrese D, Pesaresi M, Cermenati G, Mitro N, Viviani B, Garcia-Segura LM, Caruso D. Levels and actions of progesterone and its metabolites in the nervous system during physiological and pathological conditions. Progress in Neurobiology. 113: 56-69. PMID 23958466 DOI: 10.1016/j.pneurobio.2013.07.006  0.318
2013 Grassi D, Lagunas N, Amorin M, Pinos H, Panzica GC, Garcia-Segura LM, Collado P. Estrogenic regulation of NADPH-diaphorase in the supraoptic and paraventricular nuclei under acute osmotic stress. Neuroscience. 248: 127-35. PMID 23707802 DOI: 10.1016/j.neuroscience.2013.05.024  0.3
2013 Ruiz-Palmero I, Hernando M, Garcia-Segura LM, Arevalo MA. G protein-coupled estrogen receptor is required for the neuritogenic mechanism of 17β-estradiol in developing hippocampal neurons. Molecular and Cellular Endocrinology. 372: 105-15. PMID 23545157 DOI: 10.1016/j.mce.2013.03.018  0.309
2013 De Marinis E, Acaz-Fonseca E, Arevalo MA, Ascenzi P, Fiocchetti M, Marino M, Garcia-Segura LM. 17β-Oestradiol anti-inflammatory effects in primary astrocytes require oestrogen receptor β-mediated neuroglobin up-regulation. Journal of Neuroendocrinology. 25: 260-70. PMID 23190172 DOI: 10.1111/jne.12007  0.314
2013 Grassi D, Lagunas N, Amorim M, Pinos H, Panzica G, Garcia-Segura LM, Collado P. Role of oestrogen receptors on the modulation of NADPH-diaphorase-positive cell number in supraoptic and paraventricular nuclei of ovariectomised female rats. Journal of Neuroendocrinology. 25: 244-50. PMID 22967140 DOI: 10.1111/J.1365-2826.2012.02387.X  0.335
2013 Arevalo MA, Santos-Galindo M, Acaz-Fonseca E, Azcoitia I, Garcia-Segura LM. Gonadal hormones and the control of reactive gliosis. Hormones and Behavior. 63: 216-21. PMID 22401743 DOI: 10.1016/j.yhbeh.2012.02.021  0.668
2013 Azcoitia I, Arevalo MA, Garcia-Segura LM. Brain Aromatase and Neuroprotection in Mammals Brain Aromatase, Estrogens, and Behavior. DOI: 10.1093/acprof:oso/9780199841196.003.0019  0.622
2012 De Nicola AF, Brocca ME, Pietranera L, Garcia-Segura LM. Neuroprotection and sex steroid hormones: evidence of estradiol-mediated protection in hypertensive encephalopathy. Mini Reviews in Medicinal Chemistry. 12: 1081-9. PMID 22827218 DOI: 10.2174/138955712802762121  0.406
2012 Panzica GC, Balthazart J, Frye CA, Garcia-Segura LM, Herbison AE, Mensah-Nyagan AG, McCarthy MM, Melcangi RC. Milestones on Steroids and the Nervous System: 10 years of basic and translational research. Journal of Neuroendocrinology. 24: 1-15. PMID 22188420 DOI: 10.1111/J.1365-2826.2011.02265.X  0.34
2012 González-Burgos I, Rivera-Cervantes MC, Velázquez-Zamora DA, Feria-Velasco A, Garcia-Segura LM. Selective estrogen receptor modulators regulate dendritic spine plasticity in the hippocampus of male rats. Neural Plasticity. 2012: 309494. PMID 22164341 DOI: 10.1155/2012/309494  0.37
2012 Arevalo MA, Ruiz-Palmero I, Scerbo MJ, Acaz-Fonseca E, Cambiasso MJ, Garcia-Segura LM. Molecular mechanisms involved in the regulation of neuritogenesis by estradiol: Recent advances. The Journal of Steroid Biochemistry and Molecular Biology. 131: 52-6. PMID 21971420 DOI: 10.1016/j.jsbmb.2011.09.004  0.332
2012 Arevalo MA, Diz-Chaves Y, Santos-Galindo M, Bellini MJ, Garcia-Segura LM. Selective oestrogen receptor modulators decrease the inflammatory response of glial cells. Journal of Neuroendocrinology. 24: 183-90. PMID 21564348 DOI: 10.1111/j.1365-2826.2011.02156.x  0.338
2012 Azcoitia IT, Garcia-Segura LM. Hormones and the aging brain Handbook of Neuroendocrinology. 573-594. DOI: 10.1016/B978-0-12-375097-6.10026-5  0.621
2011 Arevalo MA, Ruiz-Palmero I, Simon-Areces J, Acaz-Fonseca E, Azcoitia I, Garcia-Segura LM. Estradiol meets notch signaling in developing neurons. Frontiers in Endocrinology. 2: 21. PMID 22654797 DOI: 10.3389/fendo.2011.00021  0.66
2011 Baquedano E, García-Cáceres C, Diz-Chaves Y, Lagunas N, Calmarza-Font I, Azcoitia I, Garcia-Segura LM, Argente J, Chowen JA, Frago LM. Prenatal stress induces long-term effects in cell turnover in the hippocampus-hypothalamus-pituitary axis in adult male rats. Plos One. 6: e27549. PMID 22096592 DOI: 10.1371/Journal.Pone.0027549  0.619
2011 Azcoitia I, Arevalo MA, De Nicola AF, Garcia-Segura LM. Neuroprotective actions of estradiol revisited. Trends in Endocrinology and Metabolism: Tem. 22: 467-73. PMID 21889354 DOI: 10.1016/j.tem.2011.08.002  0.648
2011 Lagunas N, Calmarza-Font I, Grassi D, Garcia-Segura LM. Estrogen receptor ligands counteract cognitive deficits caused by androgen deprivation in male rats. Hormones and Behavior. 59: 581-4. PMID 21376723 DOI: 10.1016/j.yhbeh.2011.02.014  0.313
2011 Azcoitia I, Yague JG, Garcia-Segura LM. Estradiol synthesis within the human brain. Neuroscience. 191: 139-47. PMID 21320576 DOI: 10.1016/j.neuroscience.2011.02.012  0.645
2011 López Rodríguez AB, Mateos Vicente B, Romero-Zerbo SY, Rodriguez-Rodriguez N, Bellini MJ, Rodriguez de Fonseca F, Bermudez-Silva FJ, Azcoitia I, Garcia-Segura LM, Viveros MP. Estradiol decreases cortical reactive astrogliosis after brain injury by a mechanism involving cannabinoid receptors. Cerebral Cortex (New York, N.Y. : 1991). 21: 2046-55. PMID 21258044 DOI: 10.1093/cercor/bhq277  0.694
2011 Ruiz-Palmero I, Simon-Areces J, Garcia-Segura LM, Arevalo MA. Notch/neurogenin 3 signalling is involved in the neuritogenic actions of oestradiol in developing hippocampal neurones. Journal of Neuroendocrinology. 23: 355-64. PMID 21251092 DOI: 10.1111/j.1365-2826.2011.02110.x  0.341
2011 Arevalo MA, Santos-Galindo M, Lagunas N, Azcoitia I, Garcia-Segura LM. Selective estrogen receptor modulators as brain therapeutic agents. Journal of Molecular Endocrinology. 46: R1-9. PMID 21071476 DOI: 10.1677/JME-10-0122  0.673
2011 Mendez P, Garcia-Segura LM, Muller D. Estradiol promotes spine growth and synapse formation without affecting pre-established networks. Hippocampus. 21: 1263-7. PMID 20928832 DOI: 10.1002/hipo.20875  0.69
2011 Arévalo MA, Garcia-Segura LM, Azcoitia I. Interactions of Estradiol and Insulin-Like Growth Factor-I in Neuroprotection: Implications for Brain Aging and Neurodegeneration Hormones in Neurodegeneration, Neuroprotection, and Neurogenesis. 1-11. DOI: 10.1002/9783527633968.ch1  0.619
2010 Azcoitia I, DonCarlos LL, Arevalo MA, Garcia-Segura LM. Therapeutic implications of brain steroidogenesis. Hormone Molecular Biology and Clinical Investigation. 1: 21-6. PMID 25961968 DOI: 10.1515/HMBCI.2010.003  0.816
2010 De Nicola AF, Pietranera L, Bellini MJ, Goya R, Brocca ME, Garcia-Segura LM. Protective effect of estrogens on the brain of rats with essential and endocrine hypertension. Hormone Molecular Biology and Clinical Investigation. 4: 549-57. PMID 25961231 DOI: 10.1515/HMBCI.2010.044  0.316
2010 De Marinis E, Ascenzi P, Pellegrini M, Galluzzo P, Bulzomi P, Arevalo MA, Garcia-Segura LM, Marino M. 17β-estradiol--a new modulator of neuroglobin levels in neurons: role in neuroprotection against Hâ‚‚Oâ‚‚-induced toxicity. Neuro-Signals. 18: 223-35. PMID 21335947 DOI: 10.1159/000323906  0.336
2010 Azcoitia I, Santos-Galindo M, Arevalo MA, Garcia-Segura LM. Role of astroglia in the neuroplastic and neuroprotective actions of estradiol. The European Journal of Neuroscience. 32: 1995-2002. PMID 21143654 DOI: 10.1111/j.1460-9568.2010.07516.x  0.687
2010 Garcia-Segura LM, Arévalo MA, Azcoitia I. Interactions of estradiol and insulin-like growth factor-I signalling in the nervous system: new advances. Progress in Brain Research. 181: 251-72. PMID 20478442 DOI: 10.1016/S0079-6123(08)81014-X  0.67
2010 van Gool SA, Wit JM, De Schutter T, De Clerck N, Postnov AA, Kremer Hovinga S, van Doorn J, Veiga SJ, Garcia-Segura LM, Karperien M. Impaired body weight and tail length gain and altered bone quality after treatment with the aromatase inhibitor exemestane in male rats. Hormone Research in Pã¦Diatrics. 73: 376-85. PMID 20389109 DOI: 10.1159/000308171  0.73
2010 Grassi D, Amorim MA, Garcia-Segura LM, Panzica G. Estrogen receptor alpha is involved in the estrogenic regulation of arginine vasopressin immunoreactivity in the supraoptic and paraventricular nuclei of ovariectomized rats. Neuroscience Letters. 474: 135-9. PMID 20298751 DOI: 10.1016/j.neulet.2010.03.022  0.382
2010 Fernández-Galaz MC, Fernández-Agulló T, Carrascosa JM, Ros M, Garcia-Segura LM. Leptin accumulation in hypothalamic and dorsal raphe neurons is inversely correlated with brain serotonin content. Brain Research. 1329: 194-202. PMID 20211152 DOI: 10.1016/j.brainres.2010.02.085  0.356
2010 Saraceno GE, Bertolino ML, Galeano P, Romero JI, Garcia-Segura LM, Capani F. Estradiol therapy in adulthood reverses glial and neuronal alterations caused by perinatal asphyxia. Experimental Neurology. 223: 615-22. PMID 20206165 DOI: 10.1016/j.expneurol.2010.02.010  0.347
2010 van Gool SA, Wit JM, De Schutter T, De Clerck N, Postnov AA, Kremer Hovinga S, van Doorn J, Veiga SJ, Garcia-Segura LM, Karperien M. Marginal growth increase, altered bone quality and polycystic ovaries in female prepubertal rats after treatment with the aromatase inhibitor exemestane. Hormone Research in Pã¦Diatrics. 73: 49-60. PMID 20190540 DOI: 10.1159/000271916  0.719
2010 Picazo O, Becerril-Montes A, Huidobro-Perez D, Garcia-Segura LM. Neuroprotective actions of the synthetic estrogen 17alpha-ethynylestradiol in the hippocampus. Cellular and Molecular Neurobiology. 30: 675-82. PMID 20044777 DOI: 10.1007/s10571-009-9490-3  0.306
2010 Arevalo MA, Santos-Galindo M, Bellini MJ, Azcoitia I, Garcia-Segura LM. Actions of estrogens on glial cells: Implications for neuroprotection. Biochimica Et Biophysica Acta. 1800: 1106-12. PMID 19818384 DOI: 10.1016/j.bbagen.2009.10.002  0.694
2010 Yague JG, Azcoitia I, DeFelipe J, Garcia-Segura LM, Muñoz A. Aromatase expression in the normal and epileptic human hippocampus. Brain Research. 1315: 41-52. PMID 19815003 DOI: 10.1016/j.brainres.2009.09.111  0.639
2010 Varea O, Arevalo MA, Garrido JJ, Garcia-Segura LM, Wandosell F, Mendez P. Interaction of estrogen receptors with insulin-like growth factor-I and Wnt signaling in the nervous system. Steroids. 75: 565-9. PMID 19778547 DOI: 10.1016/J.Steroids.2009.09.006  0.715
2010 García-Cáceres C, Diz-Chaves Y, Lagunas N, Calmarza-Font I, Azcoitia I, Garcia-Segura LM, Frago LM, Argente J, Chowen JA. The weight gain response to stress during adulthood is conditioned by both sex and prenatal stress exposure Psychoneuroendocrinology. 35: 403-413. PMID 19726133 DOI: 10.1016/J.Psyneuen.2009.08.001  0.566
2010 Etgen AM, Garcia-Segura LM. Estrogen regulation of neurotransmitter and growth factor signaling in the brain Hormones, Brain and Behavior Online. 1121-1163. DOI: 10.1016/B978-008088783-8.00033-4  0.409
2009 Barreto G, Santos-Galindo M, Diz-Chaves Y, Pernía O, Carrero P, Azcoitia I, Garcia-Segura LM. Selective estrogen receptor modulators decrease reactive astrogliosis in the injured brain: effects of aging and prolonged depletion of ovarian hormones. Endocrinology. 150: 5010-5. PMID 19797123 DOI: 10.1210/en.2009-0352  0.647
2009 DonCarlos LL, Azcoitia I, Garcia-Segura LM. Neuroprotective actions of selective estrogen receptor modulators Psychoneuroendocrinology. 34: S113-S122. PMID 19447561 DOI: 10.1016/j.psyneuen.2009.04.012  0.834
2009 Llorente R, Gallardo ML, Berzal AL, Prada C, Garcia-Segura LM, Viveros MP. Early maternal deprivation in rats induces gender-dependent effects on developing hippocampal and cerebellar cells. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 27: 233-41. PMID 19429388 DOI: 10.1016/j.ijdevneu.2009.01.002  0.335
2009 Garcia-Segura LM, Balthazart J. Steroids and neuroprotection: New advances. Frontiers in Neuroendocrinology. 30: v-ix. PMID 19393683 DOI: 10.1016/j.yfrne.2009.04.006  0.391
2009 Varea O, Garrido JJ, Dopazo A, Mendez P, Garcia-Segura LM, Wandosell F. Estradiol activates beta-catenin dependent transcription in neurons. Plos One. 4: e5153. PMID 19360103 DOI: 10.1371/Journal.Pone.0005153  0.745
2009 Tan O, Fadiel A, Chang A, Demir N, Jeffrey R, Horvath T, Garcia-Segura LM, Naftolin F. Estrogens regulate posttranslational modification of neural cell adhesion molecule during the estrogen-induced gonadotropin surge. Endocrinology. 150: 2783-90. PMID 19282389 DOI: 10.1210/en.2008-0927  0.507
2009 Marin R, Díaz M, Alonso R, Sanz A, Arévalo MA, Garcia-Segura LM. Role of estrogen receptor alpha in membrane-initiated signaling in neural cells: interaction with IGF-1 receptor. The Journal of Steroid Biochemistry and Molecular Biology. 114: 2-7. PMID 19167493 DOI: 10.1016/j.jsbmb.2008.12.014  0.323
2009 Yague JG, Garcia-Segura LM, Azcoitia I. Selective transcriptional regulation of aromatase gene by vitamin D, dexamethasone, and mifepristone in human glioma cells Endocrine. 35: 252-261. PMID 19116788 DOI: 10.1007/s12020-008-9134-2  0.592
2008 Garcia-Segura LM. Aromatase in the brain: Not just for reproduction anymore Journal of Neuroendocrinology. 20: 705-712. PMID 18601693 DOI: 10.1111/j.1365-2826.2008.01713.x  0.303
2008 Tapia-Gonzalez S, Carrero P, Pernia O, Garcia-Segura LM, Diz-Chaves Y. Selective oestrogen receptor (ER) modulators reduce microglia reactivity in vivo after peripheral inflammation: Potential role of microglial ERs Journal of Endocrinology. 198: 219-230. PMID 18460549 DOI: 10.1677/JOE-07-0294  0.307
2008 Sanz A, Carrero P, Pernía O, Garcia-Segura LM. Pubertal maturation modifies the regulation of insulin-like growth factor-I receptor signaling by estradiol in the rat prefrontal cortex Developmental Neurobiology. 68: 1018-1028. PMID 18446778 DOI: 10.1002/dneu.20641  0.331
2008 Sarkey S, Azcoitia I, Garcia-Segura LM, Garcia-Ovejero D, DonCarlos LL. Classical androgen receptors in non-classical sites in the brain. Hormones and Behavior. 53: 753-64. PMID 18402960 DOI: 10.1016/J.Yhbeh.2008.02.015  0.805
2008 Yague JG, Wang AC, Janssen WG, Hof PR, Garcia-Segura LM, Azcoitia I, Morrison JH. Aromatase distribution in the monkey temporal neocortex and hippocampus. Brain Research. 1209: 115-27. PMID 18402929 DOI: 10.1016/j.brainres.2008.02.061  0.67
2008 Garcia-Segura LM, Lorenz B, DonCarlos LL. The role of glia in the hypothalamus: implications for gonadal steroid feedback and reproductive neuroendocrine output. Reproduction (Cambridge, England). 135: 419-29. PMID 18367504 DOI: 10.1530/Rep-07-0540  0.809
2008 Melcangi RC, Garcia-Segura LM, Mensah-Nyagan AG. Neuroactive steroids: State of the art and new perspectives Cellular and Molecular Life Sciences. 65: 777-797. PMID 18038216 DOI: 10.1007/s00018-007-7403-5  0.333
2008 Morissette M, Le Saux M, D'Astous M, Jourdain S, Al Sweidi S, Morin N, Estrada-Camarena E, Mendez P, Garcia-Segura LM, Di Paolo T. Contribution of estrogen receptors alpha and beta to the effects of estradiol in the brain. The Journal of Steroid Biochemistry and Molecular Biology. 108: 327-38. PMID 17936613 DOI: 10.1016/j.jsbmb.2007.09.011  0.737
2008 Walf AA, Ciriza I, Garcia-Segura LM, Frye CA. Antisense oligodeoxynucleotides for estrogen receptor-beta and alpha attenuate estradiol's modulation of affective and sexual behavior, respectively. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 431-40. PMID 17443129 DOI: 10.1038/Sj.Npp.1301416  0.804
2008 Zsarnovszky A, Horvath TL, Garcia-Segura LM, Horvath B, Naftolin F. Oestrogen-Induced Changes in the Synaptology of the Monkey (Cercopithecus aethiops) Arcuate Nucleus During Gonadotropin Feedback: Oestrogen and synaptic plasticity Journal of Neuroendocrinology. 13: 22-28. DOI: 10.1111/J.1365-2826.2001.00602.X  0.383
2007 Veiga S, Carrero P, Pernia O, Azcoitia I, Garcia-Segura LM. Translocator protein 18 kDa is involved in the regulation of reactive gliosis. Glia. 55: 1426-36. PMID 17674368 DOI: 10.1002/glia.20558  0.812
2007 Naftolin F, Garcia-Segura LM, Horvath TL, Zsarnovszky A, Demir N, Fadiel A, Leranth C, Vondracek-Klepper S, Lewis C, Chang A, Parducz A. Estrogen-induced hypothalamic synaptic plasticity and pituitary sensitization in the control of the estrogen-induced gonadotrophin surge. Reproductive Sciences (Thousand Oaks, Calif.). 14: 101-16. PMID 17636222 DOI: 10.1177/1933719107301059  0.531
2007 Garcia-Segura LM, Diz-Chaves Y, Perez-Martin M, Darnaudéry M. Estradiol, insulin-like growth factor-I and brain aging. Psychoneuroendocrinology. 32: S57-61. PMID 17618061 DOI: 10.1016/J.Psyneuen.2007.03.001  0.403
2007 Barreto G, Veiga S, Azcoitia I, Garcia-Segura LM, Garcia-Ovejero D. Testosterone decreases reactive astroglia and reactive microglia after brain injury in male rats: Role of its metabolites, oestradiol and dihydrotestosterone European Journal of Neuroscience. 25: 3039-3046. PMID 17561817 DOI: 10.1111/J.1460-9568.2007.05563.X  0.812
2007 Csakvari E, Hoyk Z, Gyenes A, Garcia-Ovejero D, Garcia-Segura LM, Párducz A. Fluctuation of synapse density in the arcuate nucleus during the estrous cycle Neuroscience. 144: 1288-1292. PMID 17161546 DOI: 10.1016/J.Neuroscience.2006.11.008  0.662
2007 Garcia-Segura LM, Sanz A, Mendez P. Cross-talk between IGF-I and estradiol in the brain: Focus on neuroprotection Neuroendocrinology. 84: 275-279. PMID 17124377 DOI: 10.1159/000097485  0.736
2007 DonCarlos LL, Azcoitia I, Garcia-Segura LM. In search of neuroprotective therapies based on the mechanisms of estrogens Expert Review of Endocrinology and Metabolism. 2: 387-397. DOI: 10.1586/17446651.2.3.387  0.776
2006 Mendez P, Wandosell F, Garcia-Segura LM. Cross-talk between estrogen receptors and insulin-like growth factor-I receptor in the brain: Cellular and molecular mechanisms Frontiers in Neuroendocrinology. 27: 391-403. PMID 17049974 DOI: 10.1016/j.yfrne.2006.09.001  0.753
2006 Garcia-Segura LM, Melcangi RC. Steroids and glial cell function Glia. 54: 485-498. PMID 16906540 DOI: 10.1002/glia.20404  0.331
2006 Magnaghi V, Veiga S, Ballabio M, Gonzalez LC, Garcia-Segura LM, Melcangi RC. Sex-dimorphic effects of progesterone and its reduced metabolites on gene expression of myelin proteins by rat Schwann cells Journal of the Peripheral Nervous System. 11: 111-118. PMID 16787508 DOI: 10.1111/j.1085-9489.2006.00075.x  0.73
2006 Ciriza I, Carrero P, Frye CA, Garcia-Segura LM. Reduced metabolites mediate neuroprotective effects of progesterone in the adult rat hippocampus. The synthetic progestin medroxyprogesterone acetate (Provera) is not neuroprotective. Journal of Neurobiology. 66: 916-28. PMID 16758493 DOI: 10.1002/Neu.20293  0.805
2006 Veiga S, Leonelli E, Beelke M, Garcia-Segura LM, Melcangi RC. Neuroactive steroids prevent peripheral myelin alterations induced by diabetes Neuroscience Letters. 402: 150-153. PMID 16626861 DOI: 10.1016/j.neulet.2006.03.058  0.718
2006 Azcoitia I, Moreno A, Carrero P, Palacios S, Garcia-Segura LM. Neuroprotective effects of soy phytoestrogens in the rat brain Gynecological Endocrinology. 22: 63-69. PMID 16603429 DOI: 10.1080/09513590500519161  0.637
2006 Mendez P, Garcia-Segura LM. Phosphatidylinositol 3-kinase and glycogen synthase kinase 3 regulate estrogen receptor-mediated transcription in neuronal cells. Endocrinology. 147: 3027-39. PMID 16497810 DOI: 10.1210/en.2005-1224  0.704
2006 D'Astous M, Mendez P, Morissette M, Garcia-Segura LM, Di Paolo T. Implication of the phosphatidylinositol-3 kinase/protein kinase B signaling pathway in the neuroprotective effect of estradiol in the striatum of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice. Molecular Pharmacology. 69: 1492-8. PMID 16434614 DOI: 10.1124/mol.105.018671  0.694
2006 Yague JG, Muñoz A, de Monasterio-Schrader P, Defelipe J, Garcia-Segura LM, Azcoitia I. Aromatase expression in the human temporal cortex. Neuroscience. 138: 389-401. PMID 16426763 DOI: 10.1016/j.neuroscience.2005.11.054  0.614
2006 Lavaque E, Sierra A, Azcoitia I, Garcia-Segura LM. Steroidogenic acute regulatory protein in the brain Neuroscience. 138: 741-747. PMID 16338087 DOI: 10.1016/j.neuroscience.2005.05.060  0.652
2006 Lavaque E, Mayen A, Azcoitia I, Tena-Sempere M, Garcia-Segura LM. Sex differences, developmental changes, response to injury and cAMP regulation of the mRNA levels of steroidogenic acute regulatory protein, cytochrome P450scc, and aromatase in the olivocerebellar system Journal of Neurobiology. 66: 308-318. PMID 16329132 DOI: 10.1002/Neu.20221  0.639
2006 DonCarlos LL, Sarkey S, Lorenz B, Azcoitia I, Garcia-Ovejero D, Huppenbauer C, Garcia-Segura LM. Novel cellular phenotypes and subcellular sites for androgen action in the forebrain Neuroscience. 138: 801-807. PMID 16310968 DOI: 10.1016/J.Neuroscience.2005.06.020  0.829
2005 Mendez P, Cardona-Gomez GP, Garcia-Segura LM. Interactions of insulin-like growth factor-I and estrogen in the brain. Advances in Experimental Medicine and Biology. 567: 285-303. PMID 16370144 DOI: 10.1007/0-387-26274-1_12  0.701
2005 Lorenz B, Garcia-Segura LM, DonCarlos LL. Cellular phenotype of androgen receptor-immunoreactive nuclei in the developing and adult rat brain. The Journal of Comparative Neurology. 492: 456-68. PMID 16228996 DOI: 10.1002/Cne.20763  0.817
2005 Veiga S, Azcoitia I, Garcia-Segura LM. Extragonadal synthesis of estradiol is protective against kainic acid excitotoxic damage to the hippocampus Neuroreport. 16: 1599-1603. PMID 16148753 DOI: 10.1097/01.wnr.0000179081.39659.7d  0.823
2005 Leonelli E, Yague JG, Ballabio M, Azcoitia I, Magnaghi V, Schumacher M, Garcia-Segura LM, Melcangi RC. Ro5-4864, a synthetic ligand of peripheral benzodiazepine receptor, reduces aging-associated myelin degeneration in the sciatic nerve of male rats. Mechanisms of Ageing and Development. 126: 1159-63. PMID 16045970 DOI: 10.1016/j.mad.2005.06.001  0.596
2005 Perez-Martin M, Salazar V, Castillo C, Ariznavarreta C, Azcoitia I, Garcia-Segura LM, Tresguerres JAF. Estradiol and soy extract increase the production of new cells in the dentate gyrus of old rats Experimental Gerontology. 40: 450-453. PMID 15885957 DOI: 10.1016/j.exger.2005.03.003  0.618
2005 Melcangi RC, Cavarretta ITR, Ballabio M, Leonelli E, Schenone A, Azcoitia I, Garcia-Segura LM, Magnaghi V. Peripheral nerves: A target for the action of neuroactive steroids Brain Research Reviews. 48: 328-338. PMID 15850671 DOI: 10.1016/j.brainresrev.2004.12.021  0.618
2005 Garcia-Ovejero D, Azcoitia I, Doncarlos LL, Melcangi RC, Garcia-Segura LM. Glia-neuron crosstalk in the neuroprotective mechanisms of sex steroid hormones. Brain Research. Brain Research Reviews. 48: 273-86. PMID 15850667 DOI: 10.1016/J.Brainresrev.2004.12.018  0.83
2005 Mendez P, Azcoitia I, Garcia-Segura LM. Interdependence of oestrogen and insulin-like growth factor-I in the brain: potential for analysing neuroprotective mechanisms. The Journal of Endocrinology. 185: 11-7. PMID 15817823 DOI: 10.1677/joe.1.06058  0.806
2005 Azcoitia I, Perez-Martin M, Salazar V, Castillo C, Ariznavarreta C, Garcia-Segura LM, Tresguerres JAF. Growth hormone prevents neuronal loss in the aged rat hippocampus Neurobiology of Aging. 26: 697-703. PMID 15708445 DOI: 10.1016/j.neurobiolaging.2004.06.007  0.647
2005 Veiga S, Azcoitia I, Garcia-Segura LM. Ro5-4864, a peripheral benzodiazepine receptor ligand, reduces reactive gliosis and protects hippocampal hilar neurons from kainic acid excitotoxicity Journal of Neuroscience Research. 80: 129-137. PMID 15696538 DOI: 10.1002/jnr.20430  0.829
2004 Azcoitia I, Sierra A, Veiga S, Garcia-Segura LM. Brain steroidogenesis: emerging therapeutic strategies to prevent neurodegeneration. Journal of Neural Transmission (Vienna, Austria : 1996). 112: 171-6. PMID 15599615 DOI: 10.1007/s00702-004-0179-y  0.652
2004 Veiga S, Melcangi RC, Doncarlos LL, Garcia-Segura LM, Azcoitia I. Sex hormones and brain aging. Experimental Gerontology. 39: 1623-31. PMID 15582278 DOI: 10.1016/j.exger.2004.05.008  0.83
2004 Ciriza I, Carrero P, Azcoitia I, Lundeen SG, Garcia-Segura LM. Selective estrogen receptor modulators protect hippocampal neurons from kainic acid excitotoxicity: Differences with the effect of estradiol Journal of Neurobiology. 61: 209-221. PMID 15389604 DOI: 10.1002/neu.20043  0.823
2004 Yague JG, Lavaque E, Carretero J, Azcoitia I, Garcia-Segura LM. Aromatase, the enzyme responsible for estrogen biosynthesis, is expressed by human and rat glioblastomas. Neuroscience Letters. 368: 279-84. PMID 15364411 DOI: 10.1016/j.neulet.2004.07.010  0.671
2004 Cardona-Gomez P, Perez M, Avila J, Garcia-Segura LM, Wandosell F. Estradiol inhibits GSK3 and regulates interaction of estrogen receptors, GSK3, and beta-catenin in the hippocampus. Molecular and Cellular Neurosciences. 25: 363-73. PMID 15033165 DOI: 10.1016/j.mcn.2003.10.008  0.351
2004 Ciriza I, Azcoitia I, Garcia-Segura LM. Reduced progesterone metabolites protect rat hippocampal neurones from kainic acid excitotoxicity in vivo. Journal of Neuroendocrinology. 16: 58-63. PMID 14962077  0.782
2004 Garcia-Segura LM, McCarthy MM. Minireview: Role of glia in neuroendocrine function. Endocrinology. 145: 1082-6. PMID 14670989 DOI: 10.1210/En.2003-1383  0.314
2004 Melcangi RC, Azcoitia I, Ballabio M, Cavarretta I, Gonzalez LC, Leonelli E, Magnaghi V, Veiga S, Garcia-Segura LM. Neuroactive steroids influence peripheral myelination: a promising opportunity for preventing or treating age-dependent dysfunctions of peripheral nerves. Progress in Neurobiology. 71: 57-66. PMID 14611868 DOI: 10.1016/J.PNEUROBIO.2003.09.003  0.573
2004 Azcoitia I, Garcia-Segura L, DonCarlos L. Oestradiol Signalling in the Hippocampus Current Neuropharmacology. 2: 245-259. DOI: 10.2174/1570159043476783  0.768
2003 Azcoitia I, Sierra A, Veiga S, Garcia-Segura LM. Aromatase expression by reactive astroglia is neuroprotective. Annals of the New York Academy of Sciences. 1007: 298-305. PMID 14993062  0.823
2003 Garcia-Segura LM, Veiga S, Sierra A, Melcangi RC, Azcoitia I. Aromatase: a neuroprotective enzyme. Progress in Neurobiology. 71: 31-41. PMID 14611865  0.824
2003 Picazo O, Azcoitia I, Garcia-Segura LM. Neuroprotective and neurotoxic effects of estrogens. Brain Research. 990: 20-7. PMID 14568325  0.634
2003 Sierra A, Lavaque E, Perez-Martin M, Azcoitia I, Hales DB, Garcia-Segura LM. Steroidogenic acute regulatory protein in the rat brain: cellular distribution, developmental regulation and overexpression after injury. The European Journal of Neuroscience. 18: 1458-67. PMID 14511326 DOI: 10.1046/J.1460-9568.2003.02872.X  0.797
2003 Perez-Martin M, Azcoitia I, Trejo JL, Sierra A, Garcia-Segura LM. An antagonist of estrogen receptors blocks the induction of adult neurogenesis by insulin-like growth factor-I in the dentate gyrus of adult female rat. The European Journal of Neuroscience. 18: 923-30. PMID 12925018  0.783
2003 Veiga S, Garcia-Segura LM, Azcoitia I. Neuroprotection by the steroids pregnenolone and dehydroepiandrosterone is mediated by the enzyme aromatase. Journal of Neurobiology. 56: 398-406. PMID 12918023 DOI: 10.1002/neu.10249  0.83
2003 Azcoitia I, DonCarlos LL, Garcia-Segura LM. Are gonadal steroid hormones involved in disorders of brain aging? Aging Cell. 2: 31-7. PMID 12882332 DOI: 10.1046/j.1474-9728.2003.00013.x  0.808
2003 DonCarlos LL, Garcia-Ovejero D, Sarkey S, Garcia-Segura LM, Azcoitia I. Androgen receptor immunoreactivity in forebrain axons and dendrites in the rat. Endocrinology. 144: 3632-8. PMID 12865346 DOI: 10.1210/En.2002-0105  0.8
2003 Sierra A, Azcoitia I, Garcia-Segura L. Endogenous estrogen formation is neuroprotective in model of cerebellar ataxia. Endocrine. 21: 43-51. PMID 12777702  0.807
2003 Mendez P, Azcoitia I, Garcia-Segura LM. Estrogen receptor alpha forms estrogen-dependent multimolecular complexes with insulin-like growth factor receptor and phosphatidylinositol 3-kinase in the adult rat brain. Brain Research. Molecular Brain Research. 112: 170-6. PMID 12670715  0.817
2003 Cowley MA, Smith RG, Diano S, Tschöp M, Pronchuk N, Grove KL, Strasburger CJ, Bidlingmaier M, Esterman M, Heiman ML, Garcia-Segura LM, Nillni EA, Mendez P, Low MJ, Sotonyi P, et al. The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron. 37: 649-61. PMID 12597862 DOI: 10.1016/S0896-6273(03)00063-1  0.703
2003 Pérez-Martín M, Cifuentes M, Grondona JM, Bermúdez-Silva FJ, Arrabal PM, Pérez-Fígares JM, Jiménez AJ, García-Segura LM, Férnandez-Llebrez P. Neurogenesis in explants from the walls of the lateral ventricle of adult bovine brain: role of endogenous IGF-1 as a survival factor. The European Journal of Neuroscience. 17: 205-11. PMID 12542656 DOI: 10.1046/j.1460-9568.2003.02432.x  0.349
2003 Melcangi RC, Azcoitia I, Galbiati M, Magnaghi V, Garcia-Ovejero D, Garcia-Segura LM. Non-neuronal cells in the nervous system: sources and targets of neuroactive steroids Advances in Molecular and Cell Biology. 31: 535-559. DOI: 10.1016/S1569-2558(03)31024-0  0.736
2002 Azcoitia I, Doncarlos LL, Garcia-Segura LM. Estrogen and brain vulnerability. Neurotoxicity Research. 4: 235-45. PMID 12829404 DOI: 10.1080/10298420290033232  0.841
2002 Cardona-Gómez GP, Mendez P, DonCarlos LL, Azcoitia I, Garcia-Segura LM. Interactions of estrogen and insulin-like growth factor-I in the brain: molecular mechanisms and functional implications. The Journal of Steroid Biochemistry and Molecular Biology. 83: 211-7. PMID 12650718 DOI: 10.1016/S0960-0760(02)00261-3  0.833
2002 Cardona-Gomez GP, Mendez P, Garcia-Segura LM. Synergistic interaction of estradiol and insulin-like growth factor-I in the activation of PI3K/Akt signaling in the adult rat hypothalamus. Brain Research. Molecular Brain Research. 107: 80-8. PMID 12414126 DOI: 10.1016/S0169-328X(02)00449-7  0.72
2002 García-Ovejero D, Veiga S, García-Segura LM, Doncarlos LL. Glial expression of estrogen and androgen receptors after rat brain injury. The Journal of Comparative Neurology. 450: 256-71. PMID 12209854 DOI: 10.1002/Cne.10325  0.819
2002 Hansen HH, Azcoitia I, Pons S, Romero J, García-Segura LM, Ramos JA, Hansen HS, Fernández-Ruiz J. Blockade of cannabinoid CB(1) receptor function protects against in vivo disseminating brain damage following NMDA-induced excitotoxicity. Journal of Neurochemistry. 82: 154-8. PMID 12091476  0.632
2002 Fernández-Galaz MC, Diano S, Horvath TL, Garcia-Segura LM. Leptin uptake by serotonergic neurones of the dorsal raphe. Journal of Neuroendocrinology. 14: 429-34. PMID 12047717 DOI: 10.1046/J.1365-2826.2002.00783.X  0.338
2002 Ribeiro MF, Garcia-Segura LM. Dehydroepiandrosterone regulates insulin-like growth factor-1 system in adult rat hypothalamus. Endocrine. 17: 129-34. PMID 12041914 DOI: 10.1385/ENDO:17:2:129  0.31
2002 Ivanova T, Mendez P, Garcia-Segura LM, Beyer C. Rapid stimulation of the PI3-kinase/Akt signalling pathway in developing midbrain neurones by oestrogen. Journal of Neuroendocrinology. 14: 73-9. PMID 11903815 DOI: 10.1046/j.0007-1331.2001.00742.x  0.71
2001 Cardona-Gómez GP, Mendez P, DonCarlos LL, Azcoitia I, Garcia-Segura LM. Interactions of estrogens and insulin-like growth factor-I in the brain: Implications for neuroprotection Brain Research Reviews. 37: 320-334. PMID 11744097 DOI: 10.1016/S0165-0173(01)00137-0  0.834
2001 Azcoitia I, Garcia-Ovejero D, Chowen JA, Garcia-Segura LM. Astroglia play a key role in the neuroprotective actions of estrogen. Progress in Brain Research. 132: 469-78. PMID 11545012 DOI: 10.1016/S0079-6123(01)32096-4  0.765
2001 Azcoitia I, Sierra A, Veiga S, Honda S, Harada N, Garcia-Segura LM. Brain aromatase is neuroprotective. Journal of Neurobiology. 47: 318-29. PMID 11351342 DOI: 10.1002/NEU.1038  0.811
2001 Zsarnovszky A, Horvath TL, Garcia-Segura LM, Horvath B, Naftolin F. Oestrogen-induced changes in the synaptology of the monkey (Cercopithecus aethiops) arcuate nucleus during gonadotropin feedback. Journal of Neuroendocrinology. 13: 22-8. PMID 11123512 DOI: 10.1046/j.1365-2826.2001.00602.x  0.462
2001 Chowen JA, Azcoitia I, Cardona-Gomez GP, Garcia-Segura LM. Sex steroids and the brain: lessons from animal studies. Journal of Pediatric Endocrinology & Metabolism : Jpem. 13: 1045-66. PMID 11085182 DOI: 10.1515/Jpem.2000.13.8.1045  0.698
2000 Garcia-Segura LM, Cardona-Gómez GP, Chowen JA, Azcoitia I. Insulin-like growth factor-I receptors and estrogen receptors interact in the promotion of neuronal survival and neuroprotection Journal of Neurocytology. 29: 425-437. PMID 11424959 DOI: 10.1023/A:1007125626308  0.674
2000 Garcia-Segura LM, Azcoitia I, DonCarlos LL. Neuroprotection by estradiol. Progress in Neurobiology. 63: 29-60. PMID 11040417 DOI: 10.1016/S0301-0082(00)00025-3  0.835
2000 Cardona-Gómez GP, Doncarlos L, Garcia-Segura LM. Insulin-like growth factor I receptors and estrogen receptors colocalize in female rat brain Neuroscience. 99: 751-760. PMID 10974438 DOI: 10.1016/S0306-4522(00)00228-1  0.808
2000 Azcoitia I, Fernandez-Galaz C, Sierra A, Garcia-Segura LM. Gonadal hormones affect neuronal vulnerability to excitotoxin-induced degeneration. Journal of Neurocytology. 28: 699-710. PMID 10859573 DOI: 10.1023/A:1007025219044  0.667
2000 Cardona-Gómez GP, Trejo JL, Fernandez AM, Garcia-Segura LM. Estrogen receptors and insulin-like growth factor-I receptors mediate estrogen-dependent synaptic plasticity Neuroreport. 11: 1735-1738. PMID 10852234 DOI: 10.1097/00001756-200006050-00027  0.325
2000 Cardona-Gómez GP, Chowen JA, Garcia-Segura LM. Estradiol and progesterone regulate the expression of insulin-like growth factor-I receptor and insulin-like growth factor binding protein-2 in the hypothalamus of adult female rats Journal of Neurobiology. 43: 269-281. PMID 10842239 DOI: 10.1002/(Sici)1097-4695(20000605)43:3<269::Aid-Neu5>3.0.Co;2-D  0.351
2000 Azcoitia I, Sierra A, Garcia-Segura LM. Neuroprotective effects of estradiol in the adult rat hippocampus: interaction with insulin-like growth factor-I signalling. Journal of Neuroscience Research. 58: 815-22. PMID 10583912 DOI: 10.1002/(SICI)1097-4547(19991215)58:6<815::AID-JNR8>3.0.CO;2-R  0.693
1999 Garcia-Segura LM, Naftolin F, Hutchison JB, Azcoitia I, Chowen JA. Role of astroglia in estrogen regulation of synaptic plasticity and brain repair. Journal of Neurobiology. 40: 574-84. PMID 10453057 DOI: 10.1002/(SICI)1097-4695(19990915)40:4<574::AID-NEU12>3.0.CO;2-8  0.758
1999 Mor G, Nilsen J, Horvath T, Bechmann I, Brown S, Garcia-Segura LM, Naftolin F. Estrogen and microglia: A regulatory system that affects the brain. Journal of Neurobiology. 40: 484-96. PMID 10453051 DOI: 10.1002/(SICI)1097-4695(19990915)40:4<484::AID-NEU6>3.0.CO;2-C  0.589
1999 Fernandez-Galaz MC, Naftolin F, Garcia-Segura LM. Phasic synaptic remodeling of the rat arcuate nucleus during the estrous cycle depends on insulin-like growth factor-I receptor activation. Journal of Neuroscience Research. 55: 286-92. PMID 10348659 DOI: 10.1002/(SICI)1097-4547(19990201)55:3<286::AID-JNR3>3.0.CO;2-4  0.532
1999 García-Estrada J, Luquín S, Fernández AM, Garcia-Segura LM. Dehydroepiandrosterone, pregnenolone and sex steroids down-regulate reactive astroglia in the male rat brain after a penetrating brain injury. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 17: 145-51. PMID 10221674 DOI: 10.1016/S0736-5748(98)00065-3  0.369
1999 Garcia-Segura LM, Wozniak A, Azcoitia I, Rodriguez JR, Hutchison RE, Hutchison JB. Aromatase expression by astrocytes after brain injury: implications for local estrogen formation in brain repair. Neuroscience. 89: 567-78. PMID 10077336 DOI: 10.1016/S0306-4522(98)00340-6  0.699
1999 Azcoitia I, Sierra A, Garcia-Segura LM. Estradiol prevents kainic acid-induced neuronal loss in the rat dentate gyrus. Neuroreport. 9: 3075-9. PMID 9804319 DOI: 10.1097/00001756-199809140-00029  0.645
1999 Naftolin F, Horvath T, Garcia-Segura L. O-085. Modulation of synapses during sexual differentiation of the brain Human Reproduction. 14: 46-47. DOI: 10.1093/humrep/14.Suppl_3.46-a  0.392
1998 Garcia-Segura LM, Cardona-Gomez P, Naftolin F, Chowen JA. Estradiol upregulates Bcl-2 expression in adult brain neurons. Neuroreport. 9: 593-7. PMID 9559922 DOI: 10.1097/00001756-199803090-00006  0.586
1997 Fernandez-Galaz MC, Morschl E, Chowen JA, Torres-Aleman I, Naftolin F, Garcia-Segura LM. Role of astroglia and insulin-like growth factor-I in gonadal hormone-dependent synaptic plasticity. Brain Research Bulletin. 44: 525-31. PMID 9370220 DOI: 10.1016/S0361-9230(97)00238-4  0.588
1997 Garcia-Segura LM, Rodriguez JR, Torres-Aleman I. Localization of the insulin-like growth factor I receptor in the cerebellum and hypothalamus of adult rats: an electron microscopic study. Journal of Neurocytology. 26: 479-90. PMID 9306246 DOI: 10.1023/A:1018581407804  0.359
1997 Horvath TL, Garcia-Segura LM, Naftolin F. Control of gonadotropin feedback: the possible role of estrogen-induced hypothalamic synaptic plasticity. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology. 11: 139-43. PMID 9174856 DOI: 10.3109/09513599709152525  0.451
1997 Horvath TL, Garcia-Segura LM, Naftolin F. Lack of gonadotropin-positive feedback in the male rat is associated with lack of estrogen-induced synaptic plasticity in the arcuate nucleus. Neuroendocrinology. 65: 136-40. PMID 9067991 DOI: 10.1159/000127173  0.468
1997 Fernandez-Galaz MC, Parducz A, Naftolin F, Torres-Aleman I, Garcia-Segura LM. Interaction of gonadal steroids and growth factors in brain sex differentiation Biomedical Reviews. 7: 67-74. DOI: 10.14748/Bmr.V7.163  0.552
1996 Naftolin F, Mor G, Horvath TL, Luquin S, Fajer AB, Kohen F, Garcia-Segura LM. Synaptic remodeling in the arcuate nucleus during the estrous cycle is induced by estrogen and precedes the preovulatory gonadotropin surge. Endocrinology. 137: 5576-80. PMID 8940386 DOI: 10.1210/endo.137.12.8940386  0.446
1996 Duenas M, Torres-Aleman I, Naftolin F, Garcia-Segura LM. Interaction of insulin-like growth factor-I and estradiol signaling pathways on hypothalamic neuronal differentiation. Neuroscience. 74: 531-9. PMID 8865203 DOI: 10.1016/0306-4522(96)00142-X  0.529
1996 Garcia-Segura LM, Chowen JA, Naftolin F. Endocrine glia: roles of glial cells in the brain actions of steroid and thyroid hormones and in the regulation of hormone secretion. Frontiers in Neuroendocrinology. 17: 180-211. PMID 8812295 DOI: 10.1006/frne.1996.0005  0.558
1996 Párducz A, Szilágyi T, Hoyk S, Naftolin F, Garcia-Segura LM. Neuroplastic changes in the hypothalamic arcuate nucleus: the estradiol effect is accompanied by increased exoendocytotic activity of neuronal membranes. Cellular and Molecular Neurobiology. 16: 259-69. PMID 8743973 DOI: 10.1007/BF02088180  0.474
1996 Garcia-Segura LM, Chowen JA, Dueñas M, Parducz A, Naftolin F. Gonadal steroids and astroglial plasticity. Cellular and Molecular Neurobiology. 16: 225-37. PMID 8743971 DOI: 10.1007/Bf02088178  0.556
1996 Naftolin F, Leranth C, Horvath TL, Garcia-Segura LM. Potential neuronal mechanisms of estrogen actions in synaptogenesis and synaptic plasticity. Cellular and Molecular Neurobiology. 16: 213-23. PMID 8743970 DOI: 10.1007/Bf02088177  0.502
1996 Naftolin F, Horvath T, Garcia-Segura L. A45 The effects of estrogen on primate brain circuitry Maturitas. 27: 14. DOI: 10.1016/S0378-5122(97)80881-X  0.439
1996 Garcia-Segura L, Femandez-Galaz C, Chowen J, Naftolin F. A44 Effects of hormonal steroids on brain cells Maturitas. 27: 13-14. DOI: 10.1016/S0378-5122(97)80880-8  0.446
1995 Garcia-Segura LM, Cañas B, Parducz A, Rougon G, Theodosis D, Naftolin F, Torres-Aleman I. Estradiol promotion of changes in the morphology of astroglia growing in culture depends on the expression of polysialic acid of neural membranes. Glia. 13: 209-16. PMID 7782106 DOI: 10.1002/glia.440130307  0.522
1995 Garcia-Segura LM, Dueñas M, Busiguina S, Naftolin F, Chowen JA. Gonadal hormone regulation of neuronal-glial interactions in the developing neuroendocrine hypothalamus. The Journal of Steroid Biochemistry and Molecular Biology. 53: 293-8. PMID 7626470 DOI: 10.1016/0960-0760(95)00066-9  0.546
1995 Horvath TL, Leedom L, Lewis C, Garcia-Segura L, Naftolin F. Estrogen-induced hypothalamic synaptic plasticity and the regulation of gonadotrophins Current Opinion in Endocrinology and Diabetes. 2: 186. DOI: 10.1097/00060793-199504000-00018  0.435
1994 Garcia-Segura LM, Luquín S, Párducz A, Naftolin F. Gonadal hormone regulation of glial fibrillary acidic protein immunoreactivity and glial ultrastructure in the rat neuroendocrine hypothalamus. Glia. 10: 59-69. PMID 8300192 DOI: 10.1002/glia.440100108  0.525
1994 Dueñas M, Luquín S, Chowen JA, Torres-Alemán I, Naftolin F, Garcia-Segura LM. Gonadal hormone regulation of insulin-like growth factor-I-like immunoreactivity in hypothalamic astroglia of developing and adult rats. Neuroendocrinology. 59: 528-38. PMID 8084376 DOI: 10.1159/000126702  0.532
1994 Keefe D, Garcia-Segura LM, Naftolin F. New insights into estrogen action on the brain. Neurobiology of Aging. 15: 495-7. PMID 7969729 DOI: 10.1016/0197-4580(94)90086-8  0.487
1994 Garcia-Segura LM, Chowen JA, Dueñas M, Torres-Aleman I, Naftolin F. Gonadal steroids as promoters of neuro-glial plasticity. Psychoneuroendocrinology. 19: 445-53. PMID 7938345 DOI: 10.1016/0306-4530(94)90031-0  0.537
1994 Leedom L, Lewis C, Garcia-Segura LM, Naftolin F. Regulation of arcuate nucleus synaptology by estrogen. Annals of the New York Academy of Sciences. 743: 61-71. PMID 7802419 DOI: 10.1111/j.1749-6632.1994.tb55787.x  0.53
1993 García-Segura LM, Luquín S, Martínez P, Casas MT, Suau P. Differential expression and gonadal hormone regulation of histone H1° in the developing and adult rat brain Developmental Brain Research. 73: 63-70. PMID 8513555 DOI: 10.1016/0165-3806(93)90046-D  0.361
1993 Perez J, Naftolin F, Garcia-Segura LM. Cycloheximide mimics effects of oestradiol that are linked to synaptic plasticity of hypothalamic neurons. Journal of Neurocytology. 22: 233-43. PMID 8478644 DOI: 10.1007/Bf01187122  0.524
1993 Naftolin F, Leranth C, Perez J, Garcia-Segura LM. Estrogen induces synaptic plasticity in adult primate neurons. Neuroendocrinology. 57: 935-9. PMID 8413829 DOI: 10.1159/000126456  0.468
1993 Garcia-Estrada J, Rio JAD, Luquin S, Soriano E, Garcia-Segura LM. Gonadal hormones down-regulate reactive gliosis and astrocyte proliferation after a penetrating brain injury Brain Research. 628: 271-278. PMID 8313156 DOI: 10.1016/0006-8993(93)90964-O  0.353
1993 Luquin S, Naftolin F, Garcia-Segura LM. Natural fluctuation and gonadal hormone regulation of astrocyte immunoreactivity in dentate gyrus. Journal of Neurobiology. 24: 913-24. PMID 8228969 DOI: 10.1002/neu.480240705  0.47
1993 Chowen JA, Argente J, Torres-Alemán I, González-Parra S, García-Segura LM. Effects of the neonatal sex steroid environment on growth hormone-releasing hormone and somatostatin gene expression. The Journal of Pediatric Endocrinology. 6: 211-8. PMID 7920984 DOI: 10.1515/Jpem.1993.6.3-4.211  0.316
1992 Garcia-Segura LM, Diolez-Bojda F, Lenoir V, Naftolin F, Kerdelhué B. Estrogen-like effects of the mammary carcinogen 7,12-dimethylbenz(alpha)anthracene on hypothalamic neuronal membranes. Brain Research Bulletin. 28: 625-8. PMID 1617445 DOI: 10.1016/0361-9230(92)90113-C  0.492
1992 Torres-Aleman I, Rejas MT, Pons S, Garcia-Segura LM. Estradiol promotes cell shape changes and glial fibrillary acidic protein redistribution in hypothalamic astrocytes in vitro: a neuronal-mediated effect. Glia. 6: 180-7. PMID 1478729 DOI: 10.1002/glia.440060305  0.315
1992 Naftolin F, Leranth C, Garcia-Segura LM. Ultrastructural changes in hypothalamic cells during estrogen-induced gonadotrophin feedback Neuroprotocols. 1: 16-26. DOI: 10.1016/1058-6741(92)90017-R  0.543
1991 Garcia-Segura LM, Perez J, Jones E, Naftolin F. Loss of sexual dimorphism in rat arcuate nucleus neuronal membranes with reproductive aging. Experimental Neurology. 112: 125-8. PMID 2013307 DOI: 10.1016/0014-4886(91)90122-S  0.441
1991 Naftolin F, Keefe D, Apa R, Palumbo A, Garcia-Segura LM. The apparent paradox of sexual differentiation of the brain. Contributions to Gynecology and Obstetrics. 18: 24-32. PMID 1935127 DOI: 10.1159/000418452  0.398
1991 García-Segura LM, Pérez J, Pons S, Rejas MT, Torres-Alemán I. Localization of insulin-like growth factor I (IGF-I)-like immunoreactivity in the developing and adult rat brain. Brain Research. 560: 167-74. PMID 1722132  0.327
1990 Perez J, Tranque PA, Naftolin F, Garcia-Segura LM. Gap junctions in the hypothalamic arcuate neurons of ovariectomized and estradiol-treated rats. Neuroscience Letters. 108: 17-21. PMID 2304626 DOI: 10.1016/0304-3940(90)90699-A  0.486
1990 Naftolin F, Perez J, Leranth CS, Redmond DE, Garcia-Segura LM. African green monkeys have sexually dimorphic and estrogen-sensitive hypothalamic neuronal membranes. Brain Research Bulletin. 25: 575-9. PMID 2271961 DOI: 10.1016/0361-9230(90)90114-F  0.471
1990 Naftolin F, Garcia-Segura LM, Keefe D, Leranth C, Maclusky NJ, Brawer JR. Estrogen effects on the synaptology and neural membranes of the rat hypothalamic arcuate nucleus. Biology of Reproduction. 42: 21-8. PMID 2178699 DOI: 10.1095/Biolreprod42.1.21  0.53
1989 Garcia-Segura LM, Suarez I, Segovia S, Tranque PA, Calés JM, Aguilera P, Olmos G, Guillamón A. The distribution of glial fibrillary acidic protein in the adult rat brain is influenced by the neonatal levels of sex steroids. Brain Research. 456: 357-63. PMID 3061565 DOI: 10.1016/0006-8993(88)90239-9  0.319
1989 Garcia-Segura LM, Olmos G, Robbins RJ, Hernandez P, Meyer JH, Naftolin F. Estradiol induces rapid remodelling of plasma membranes in developing rat cerebrocortical neurons in culture. Brain Research. 498: 339-43. PMID 2790487 DOI: 10.1016/0006-8993(89)91113-X  0.439
1989 Garcia-Segura LM, Torres-Aleman I, Naftolin F. Astrocytic shape and glial fibrillary acidic protein immunoreactivity are modified by estradiol in primary rat hypothalamic cultures. Brain Research. Developmental Brain Research. 47: 298-302. PMID 2743562 DOI: 10.1016/0165-3806(89)90186-7  0.463
1989 Garcia-Segura LM, Perez J, Tranque PA, Olmos G, Naftolin F. Sex differences in plasma membrane concanavalin A binding in the rat arcuate neurons. Brain Research Bulletin. 22: 651-5. PMID 2736394 DOI: 10.1016/0361-9230(89)90085-3  0.451
1989 Olmos G, Naftolin F, Perez J, Tranque PA, Garcia-Segura LM. Synaptic remodeling in the rat arcuate nucleus during the estrous cycle. Neuroscience. 32: 663-7. PMID 2601838 DOI: 10.1016/0306-4522(89)90288-1  0.436
1988 Naftolin F, MacLusky NJ, Leranth CZ, Sakamoto HS, Garcia-Segura LM. The cellular effects of estrogens on neuroendocrine tissues. Journal of Steroid Biochemistry. 30: 195-207. PMID 3290581 DOI: 10.1016/0022-4731(88)90093-3  0.541
1988 Garcia-Segura LM, Perez J, Tranque PA, Olmos G, Naftolin F. Sexual differentiation of the neuronal plasma membrane: neonatal levels of sex steroids modulate the number of exo-endocytotic images in the developing rat arcuate neurons. Neuroscience Letters. 91: 19-23. PMID 3173783 DOI: 10.1016/0304-3940(88)90242-X  0.447
1988 Garcia-Segura LM, Hernandez P, Olmos G, Tranque PA, Naftolin F. Neuronal membrane remodelling during the oestrus cycle: a freeze-fracture study in the arcuate nucleus of the rat hypothalamus. Journal of Neurocytology. 17: 377-83. PMID 3171611 DOI: 10.1007/Bf01187859  0.4
1987 Olmos G, Aguilera P, Tranque P, Naftolin F, Garcia-Segura LM. Estrogen-induced synaptic remodelling in adult rat brain is accompanied by the reorganization of neuronal membranes. Brain Research. 425: 57-64. PMID 3427426 DOI: 10.1016/0006-8993(87)90483-5  0.504
1987 Garcia-Segura LM, Olmos G, Tranque P, Naftolin F. Rapid effects of gonadal steroids upon hypothalamic neuronal membrane ultrastructure. Journal of Steroid Biochemistry. 27: 615-23. PMID 3121927 DOI: 10.1016/0022-4731(87)90361-X  0.453
1986 Garcia-Segura LM, Baetens D, Naftolin F. Synaptic remodelling in arcuate nucleus after injection of estradiol valerate in adult female rats. Brain Research. 366: 131-6. PMID 3697673 DOI: 10.1016/0006-8993(86)91287-4  0.459
1986 Garcia-Segura LM, Barnea ER, Biggers W, Naftolin F, Sanyal MK. Insulin modulates neuronal plasma membrane development in human fetal spinal cord neurons in culture. Neuroscience Letters. 65: 283-6. PMID 3520396 DOI: 10.1016/0304-3940(86)90275-2  0.424
1985 Garcia-Segura LM, Baetens D, Naftolin F. Sex differences and maturational changes in arcuate nucleus neuronal plasma membrane organization. Brain Research. 351: 146-9. PMID 3995337 DOI: 10.1016/0165-3806(85)90241-X  0.443
1985 Naftolin F, Bruhlmann-Papazyan M, Baetens D, Garcia-Segura LM. Neurons with whorl bodies have increased numbers of synapses. Brain Research. 329: 289-93. PMID 3978449 DOI: 10.1016/0006-8993(85)90536-0  0.468
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