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David A. Horne, Ph.D. - Publications

Affiliations: 
1983-1988 Chemistry Massachusetts Institute of Technology, Cambridge, MA, United States 
 2006- City of Hope and Beckman Research Institute, USA 
Area:
Natural Products, Molecular Medicine
Website:
https://www.cityofhope.org/people/horne-david
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36 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Jana S, Krishna BM, Singhal J, Horne D, Awasthi S, Salgia R, Singhal SS. SOX9: The Master Regulator of Cell Fate in Breast Cancer. Biochemical Pharmacology. 113789. PMID 31911091 DOI: 10.1016/J.Bcp.2019.113789  0.326
2019 Krishna BM, Jana S, Singhal J, Horne D, Awasthi S, Salgia R, Singhal SS. Notch signaling in breast cancer: From pathway analysis to therapy. Cancer Letters. 461: 123-131. PMID 31326555 DOI: 10.1016/J.Canlet.2019.07.012  0.321
2019 Wen W, Han ES, Dellinger TH, Wu J, Guo Y, Buettner R, Horne DA, Jove R, Yim JH. Increasing Antitumor Activity of JAK Inhibitor by Simultaneous Blocking Multiple Survival Signaling Pathways in Human Ovarian Cancer. Translational Oncology. 12: 1015-1025. PMID 31141756 DOI: 10.1016/J.Tranon.2019.05.003  0.311
2019 Michalak SE, Nam S, Kwon DM, Horne DA, Vanderwal CD. A Chlorine-Atom-Controlled Terminal-Epoxide-Initiated Bicyclization Cascade Enables a Synthesis of the Potent Cytotoxins Haterumaimides J and K. Journal of the American Chemical Society. PMID 31129963 DOI: 10.1021/Jacs.9B04702  0.359
2019 Singhal SS, Salgia R, Singhal S, Horne D, Awasthi S. RLIP: An existential requirement for breast carcinogenesis. Biochimica Et Biophysica Acta. Reviews On Cancer. 1871: 281-288. PMID 30771458 DOI: 10.1016/J.Bbcan.2019.02.001  0.328
2018 Nagaprashantha LD, Singhal J, Chikara S, Gugiu G, Horne D, Awasthi S, Salgia R, Singhal SS. 2'-Hydroxyflavanone induced changes in the proteomic profile of breast cancer cells. Journal of Proteomics. PMID 30248461 DOI: 10.1016/J.Jprot.2018.09.005  0.306
2018 Singhal J, Chikara S, Horne D, Salgia R, Awasthi S, Singhal SS. 2'-Hydroxyflavanone inhibits in vitro and in vivo growth of breast cancer cells by targeting RLIP76. Molecular Carcinogenesis. PMID 30136444 DOI: 10.1002/Mc.22894  0.314
2018 Gu L, Lingeman RG, Yakushijin F, Sun E, Cui Q, Chao J, Hu W, Li H, Hickey RJ, Stark JM, Yuan YC, Chen Y, Vonderfecht SL, Synold TW, Shi Y, ... ... Horne D, et al. The anti-cancer activity of a first-in-class small molecule targeting PCNA. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 29967249 DOI: 10.1158/1078-0432.Ccr-18-0592  0.329
2018 Nagaprashantha LD, Singhal J, Li H, Warden C, Liu X, Horne D, Awasthi S, Salgia R, Singhal SS. 2'-Hydroxyflavanone effectively targets RLIP76-mediated drug transport and regulates critical signaling networks in breast cancer. Oncotarget. 9: 18053-18068. PMID 29719590 DOI: 10.18632/Oncotarget.24720  0.317
2017 Singhal J, Nagaprashantha L, Chikara S, Awasthi S, Horne D, Singhal SS. 2'-Hydroxyflavanone: A novel strategy for targeting breast cancer. Oncotarget. 8: 75025-75037. PMID 29088842 DOI: 10.18632/Oncotarget.20499  0.307
2017 Könst ZA, Szklarski AR, Pellegrino S, Michalak SE, Meyer M, Zanette C, Cencic R, Nam S, Voora VK, Horne DA, Pelletier J, Mobley DL, Yusupova G, Yusupov M, Vanderwal CD. Synthesis facilitates an understanding of the structural basis for translation inhibition by the lissoclimides. Nature Chemistry. 9: 1140-1149. PMID 29064494 DOI: 10.1038/Nchem.2800  0.353
2017 Singhal SS, Jain D, Singhal P, Awasthi S, Singhal J, Horne D. Targeting the mercapturic acid pathway and vicenin-2 for prevention of prostate cancer. Biochimica Et Biophysica Acta. PMID 28359741 DOI: 10.1016/J.Bbcan.2017.03.009  0.307
2017 Singhal SS, Singhal S, Singhal P, Singhal J, Horne D, Awasthi S. Didymin: an orally active citrus flavonoid for targeting neuroblastoma. Oncotarget. PMID 28187004 DOI: 10.18632/Oncotarget.15204  0.324
2016 Giannouli V, Lougiakis N, Kostakis IK, Pouli N, Marakos P, Skaltsounis AL, Nam S, Jove R, Horne D, Tenta R, Pratsinis H, Kletsas D. The discovery of new cytotoxic pyrazolopyridine derivatives. Bioorganic & Medicinal Chemistry Letters. PMID 27720292 DOI: 10.1016/J.Bmcl.2016.09.056  0.316
2015 Quinn RK, Könst ZA, Michalak SE, Schmidt Y, Szklarski AR, Flores AR, Nam S, Horne DA, Vanderwal CD, Alexanian EJ. Site-Selective Aliphatic C-H Chlorination Using N-Chloroamides Enables a Synthesis of Chlorolissoclimide. Journal of the American Chemical Society. PMID 26694767 DOI: 10.1021/Jacs.5B12308  0.346
2015 Baumann M, Dieskau AP, Loertscher BM, Walton MC, Nam S, Xie J, Horne D, Overman LE. Tricyclic Analogues of Epidithiodioxopiperazine Alkaloids with Promising In Vitro and In Vivo Antitumor Activity. Chemical Science (Royal Society of Chemistry : 2010). 6: 4451-4457. PMID 26301062 DOI: 10.1039/C5Sc01536G  0.347
2015 Wang Y, Han E, Xing Q, Yan J, Arrington A, Wang C, Tully D, Kowolik CM, Lu DM, Frankel PH, Zhai J, Wen W, Horne D, Yip ML, Yim JH. Baicalein upregulates DDIT4 expression which mediates mTOR inhibition and growth inhibition in cancer cells. Cancer Letters. 358: 170-9. PMID 25543165 DOI: 10.1016/J.Canlet.2014.12.033  0.328
2014 Wen W, Liang W, Wu J, Kowolik CM, Buettner R, Scuto A, Hsieh MY, Hong H, Brown CE, Forman SJ, Horne D, Morgan R, Wakabayashi M, Dellinger TH, Han ES, et al. Targeting JAK1/STAT3 signaling suppresses tumor progression and metastasis in a peritoneal model of human ovarian cancer. Molecular Cancer Therapeutics. 13: 3037-48. PMID 25319391 DOI: 10.1158/1535-7163.Mct-14-0077  0.303
2014 Yang F, Nam S, Brown CE, Zhao R, Starr R, Ma Y, Xie J, Horne DA, Malkas LH, Jove R, Hickey RJ. A novel berbamine derivative inhibits cell viability and induces apoptosis in cancer stem-like cells of human glioblastoma, via up-regulation of miRNA-4284 and JNK/AP-1 signaling. Plos One. 9: e94443. PMID 24732116 DOI: 10.1371/Journal.Pone.0094443  0.35
2013 Lu L, Zhang W, Nam S, Horne DA, Jove R, Carter RG. Amphidinolide B: total synthesis, structural investigation, and biological evaluation. The Journal of Organic Chemistry. 78: 2213-47. PMID 23406192 DOI: 10.1021/Jo3026077  0.333
2012 Nam S, Xie J, Perkins A, Ma Y, Yang F, Wu J, Wang Y, Xu RZ, Huang W, Horne DA, Jove R. Novel synthetic derivatives of the natural product berbamine inhibit Jak2/Stat3 signaling and induce apoptosis of human melanoma cells. Molecular Oncology. 6: 484-93. PMID 22717603 DOI: 10.1016/J.Molonc.2012.05.002  0.344
2012 Yang F, Nam S, Zhao R, Tian Y, Horne D, Jove R. Abstract 2069: A novel berbamine derivative induces apoptosis of chemotherapy-resistant human osteosarcoma cells through activation of ROS/JNK signaling Cancer Research. 72: 2069-2069. DOI: 10.1158/1538-7445.Am2012-2069  0.336
2011 Buettner R, Corzano R, Rashid R, Lin J, Senthil M, Hedvat M, Schroeder A, Mao A, Herrmann A, Yim J, Li H, Yuan YC, Yakushijin K, Yakushijin F, Vaidehi N, ... ... Horne D, et al. Alkylation of cysteine 468 in Stat3 defines a novel site for therapeutic development. Acs Chemical Biology. 6: 432-43. PMID 21226522 DOI: 10.1021/Cb100253E  0.36
1999 Horne DA, Yakushijin K, Büchi G. Biomimetic synthesis of the neolignans kadsurenone, denudatin B, O- methyl-liliflodione, and liliflol B Tetrahedron Letters. 40: 5443-5447. DOI: 10.1016/S0040-4039(99)01063-1  0.468
1998 Olofson A, Yakushijin K, Horne DA. Synthesis of Marine Sponge Alkaloids Oroidin, Clathrodin, and Dispacamides. Preparation and Transformation of 2-Amino-4,5-dialkoxy-4,5-dihydroimidazolines from 2-Aminoimidazoles Journal of Organic Chemistry. 63: 1248-1253. DOI: 10.1021/Jo9718298  0.317
1997 Olofson A, Yakushijin K, Horne DA. Synthesis of Mauritiamine. The Journal of Organic Chemistry. 62: 7918-7919. PMID 11671892 DOI: 10.1021/Jo9715682  0.322
1997 Xu Yz, Yakushijin K, Horne DA. Synthesis of C(11)N(5) Marine Sponge Alkaloids: (+/-)-Hymenin, Stevensine, Hymenialdisine, and Debromohymenialdisine. The Journal of Organic Chemistry. 62: 456-464. PMID 11671434 DOI: 10.1021/Jo9619746  0.335
1997 Zhao X, Horne DA. The role of cysteine residues in the rearrangement of uridine to pseudouridine catalyzed by pseudouridine synthase I. The Journal of Biological Chemistry. 272: 1950-5. PMID 8999885 DOI: 10.1074/Jbc.272.3.1950  0.338
1997 Melander C, Horne DA. Kinetic Analysis of Ester Aminolysis Catalyzed by Nucleosides in a Nonpolar Medium. Evidence of Bifunctional Catalysis Journal of Organic Chemistry. 62: 9295-9297. DOI: 10.1021/Jo971614Y  0.573
1997 Melander C, Horne DA. Mutarotation of tetramethylglucose catalyzed by ribonucleosides Tetrahedron Letters. 38: 713-716. DOI: 10.1016/S0040-4039(96)02422-7  0.55
1996 Melander C, Horne DA. Ester Aminolysis Catalyzed by Nucleosides in a Nonpolar Medium. The Journal of Organic Chemistry. 61: 8344-8346. PMID 11667834 DOI: 10.1021/Jo961331Q  0.55
1996 Chihade JW, Horne DA. Single nucleotide modulation of uridine to pseudouridine rearrangement in transfer RNA catalyzed by pseudouridine synthase I. Journal of Molecular Recognition : Jmr. 9: 524-7. PMID 9174935 DOI: 10.1002/(Sici)1099-1352(199634/12)9:5/6<524::Aid-Jmr295>3.0.Co;2-4  0.666
1996 Xu YZ, Yakushijin K, Horne DA. Transbromination of brominated pyrrole and imidazole derivatives: Synthesis of the C11N5 marine alkaloid stevensine Tetrahedron Letters. 37: 8121-8124. DOI: 10.1016/0040-4039(96)01888-6  0.308
1994 Horne DA, Yakushijin K, Büchi G. A two-step synthesis of imidazoles from aldehydes via 4-tosyloxazolines Heterocycles. 39: 139-153. DOI: 10.3987/Com-93-S(B)8  0.565
1993 Horne DA, Fugmann B, Yakushijin K, Büchi G. A synthesis of pilocarpine Journal of Organic Chemistry. 58: 62-64. DOI: 10.1021/Jo00053A016  0.553
1991 Horne DA, Dervan PB. Effects of an abasic site on triple helix formation characterized by affinity cleaving. Nucleic Acids Research. 19: 4963-5. PMID 1923764 DOI: 10.1093/Nar/19.18.4963  0.416
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