Area:
Neurobiology of Learning and Memory
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High-probability grants
According to our matching algorithm, Mark G. Packard is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
1990 — 1992 |
Packard, Mark G |
F32Activity Code Description: To provide postdoctoral research training to individuals to broaden their scientific background and extend their potential for research in specified health-related areas. |
Neurochemical Modulation of Multiple Memory Systems @ University of California Irvine |
0.951 |
1995 |
Packard, Mark G |
R03Activity Code Description: To provide research support specifically limited in time and amount for studies in categorical program areas. Small grants provide flexibility for initiating studies which are generally for preliminary short-term projects and are non-renewable. |
Amygdala Modulation of Multiple Memory Systems @ Louisiana State Univ-Univ of New Orleans
The broad long-term objectives of the proposed research include an increased understanding of both the organization of memory in the mammalian brain, and the neurochemical bases of different forms of memory. These objectives will be accomplished through experimental linkage of two sets of previous findings: l) the hippocampal system and caudate nucleus are parts of independent brain memory systems, and 2) the amygdala plays a general modulatory role in memory, mediating the memory-enhancing effects of drugs affecting many neurotransmitter systems. The specific aims of the proposed research include an examination of three primary hypotheses: 1) the modulatory role of the amygdala in memory extends to different forms of memory. 2) the modulatory influences of the amygdala on memory involve dissociable effects on hippocampal and caudate nucleus memory systems, and are mediated by amygdala output via the stria terminalis. 3) the neurochemical bases of memory processes mediated by the amygdala, hippocampus and caudate nucleus involve brain dopaminergic systems. The research design and methods combine central nervous system manipulations in rats, including brain lesions and post-training intracerebral microinjections of dopaminergic agonist drugs. Rats will receive training in either a hippocampal-dependent spatial water maze task, or a caudate nucleus-dependent cued water maze task. The two tasks require rats to swim to an escape platform within a circular maze. In the hippocampal-dependent spatial task, the hidden escape platform is in a constant location, and can be located only by learning spatial relationships among distal extramaze cues. In the caudate nucleus- dependent cued task, rats are trained to swim to a visible cue mounted on a platform which is placed in a different spatial location on each trial. Immediately post-training, animals will receive intracerebral (hippocampus, caudate nucleus, or amygdala)injection of a dopamine receptor agonist or vehicle. 24 hours later rats will receive a retention test in which latency to mount the platform will be used as a measure of the previous day's training. In other groups of rats, intracerebral injections of dopaminergic agonists will be combined with lesions of the stria terminalis, in order to assess the anatomical bases of amygdala modulation of multiple memory systems. The separable roles of the hippocampal system and caudate nucleus in memory which has been established in rodents is also observable in humans with neurological disorders compromising these two brain regions. Thus, increased knowledge of the anatomical and neurochemical bases of multiple memory systems may have important implications for understanding the biological bases of human learning and memory processes.
|
0.91 |
1997 — 2001 |
Packard, Mark G |
R29Activity Code Description: Undocumented code - click on the grant title for more information. |
Neurobiology of Multiple Memory Systems @ Louisiana State Univ-Univ of New Orleans
DESCRIPTION (Adapted from applicant's abstract): The broad long-term objectives of the proposed research include an increased understanding of the organization of memory in the mammalian brain, the neurochemical bases of different forms of memory, and the modulatory influences on multiple memory systems. These objectives will be accomplished through experimental linkage of two sets of previous findings: 1) the hippocampus and caudate nucleus are parts of independent brain systems, and 2) the amygdala plays a modulatory role in memory, and can influence both hippocampal-dependent and caudate-dependent memory processes. The specific aims of the hypothesis include an examination of three primary hypotheses: 1) The ventral and dorsal regions of the pallidal complex of the brain represent additional anatomical components of the hippocampal and caudate nucleus memory systems, respectively. 2) Glutamatergic neurotransmission in the hippocampus and caudate nucleus is a critical component of the neurochemical bases of memory in these two systems. 3) The modulatory influence of the amygdala on memory involve dissociable effects on the hippocampal and caudate nucleus memory systems, and is mediated by amygdala output via the stria terminalis. The research design and methods combine central nervous system manipulations in rats, including neural inactivation (via injection of the local anesthetic lidocaine), and post-training intracerebral injections of glutamatergic agonist and antagonist drugs that are selective for NMDA, AMPA, kainate, and metabotropic receptor subtypes. The role of the pallidal complex, glutamatergic neurotransmission, and the modulatory influence of the amygdala in memory will be assessed in rats trained in either hippocampal-dependent spatial water and radial maze tasks, or caudate nucleus-dependent cued water and radial maze tasks. The separable roles of the hippocampal system and caudate nucleus in memory that has been established in rodents is also observable in humans with neurological disorders compromising these two brain regions. Thus, increased knowledge of the anatomical and neurochemical bases of multiple memory systems may have important implications for understanding the biological bases of human learning and memory.
|
0.97 |