Area:
Developmental Neuroscience, Spinal Cord Injury, Stem Cells
We are testing a new system for linking grants to scientists.
The funding information displayed below comes from the
NIH Research Portfolio Online Reporting Tools and the
NSF Award Database.
The grant data on this page is limited to grants awarded in the United States and is thus partial. It can nonetheless be used to understand how funding patterns influence mentorship networks and vice-versa, which has deep implications on how research is done.
You can help! If you notice any innacuracies, please
sign in and mark grants as correct or incorrect matches.
Sign in to see low-probability grants and correct any errors in linkage between grants and researchers.
High-probability grants
According to our matching algorithm, Ali Jalali is the likely recipient of the following grants.
| Years |
Recipients |
Code |
Title / Keywords |
Matching
score |
| 2005 — 2008 |
Jalali, Ali |
F30Activity Code Description:
Individual fellowships for predoctoral training which leads to the combined M.D./Ph.D. degrees. |
Mechanism and Function of Heyl in Neurogenesis @ Northwestern University
DESCRIPTION (provided by applicant): Neural stem cells are defined by their capacity to proliferate and self-renew indefinitely and their ability to differentiate into various neuronal and glial progeny. One of the signaling pathways involved in neural stem cells' decision between proliferation and differentiation is the Notch pathway. Members of the Hes and Hey families of transcription factors are regarded as Notch target genes which generally inhibit the differentiation of neural stem cells and maintain them in cell cycle. One of the Hey family members, HeyL, appears to have the unique ability to promote neuronal differentiation of neural stem cells in vitro, suggesting a similar role in vivo. This proposal seeks to assess the neurogenic potential of HeyL in vivo and to identify the target genes regulated by HeyL that may mediate this effect. These aims will be achieved through a series of experiments entailing overexpression or knock-down of HeyL in the nervous system of developing mouse embryos and analyzing the effects on neurogenesis. Additionally, chromatin immunoprecipitation assays and promoter reporter assays will be utilized to identify the putative transcriptional targets of HeyL. These studies will further our understanding of the underlying biology of neural stem cells and nervous system development.
|
1 |