Area:
The Role of Neuroglia in Brain Function & Disease
We are testing a new system for linking grants to scientists.
The funding information displayed below comes from the
NIH Research Portfolio Online Reporting Tools and the
NSF Award Database.
The grant data on this page is limited to grants awarded in the United States and is thus partial. It can nonetheless be used to understand how funding patterns influence mentorship networks and vice-versa, which has deep implications on how research is done.
You can help! If you notice any innacuracies, please
sign in and mark grants as correct or incorrect matches.
Sign in to see low-probability grants and correct any errors in linkage between grants and researchers.
High-probability grants
According to our matching algorithm, Stacey N. MacFarlane is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
2001 |
Macfarlane, Stacey N |
F32Activity Code Description: To provide postdoctoral research training to individuals to broaden their scientific background and extend their potential for research in specified health-related areas. |
Synucleins and Potassium Channel Function @ University of Pennsylvania
DESCRIPTION (provided by applicant): Through their control of neuronal excitability, potassium channels can alter synaptic transmission and regulate the neuronal communication that underlies the essence of all behavior. In recent years, the calcium-activated potassium channel (Slo), which plays a particular role in repolarization and, thus, neurotransmission at the neuronal synapse, has been shown to assemble with a variety of proteins that modulate its activity. Aim 1 of this proposal seeks to further explore our preliminary evidence for a binding interaction between synuclein proteins and the Slo channel via biochemical techniques such as yeast two-hybrid, and to elucidate the exact protein domains that mediate such binding by molecular biological and biochemical techniques. The goal of the second Aim is to determine the functional significance of a synuclein-Slo interaction by means of electrophysiology in heterologous co-expression systems. If the electrophysiological effects in heterologous cells are promising, then genetic approaches will be used to test for in situ effects of Slo modulation by synuclein at the Drosophila neuromuscular junction. Synuclein proteins themselves have been implicated in synaptic function through their association with synaptic vesicles and their upregulation during synaptic plasticity (for review, see Clayton and George, 1999). A better understanding of the proteins that orchestrate the events of neurotransmission will not only lead to the knowledge of the mechanisms underlying such complex behaviors as movement coordination and memory, but may also lead to an understanding of the malfunctions that occur in synuclein-related neuropathies (for review, see Goedert, 1999).
|
0.951 |