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High-probability grants
According to our matching algorithm, Damian Zuloaga is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
2006 — 2008 |
Zuloaga, Damian Gabriel |
F31Activity Code Description: To provide predoctoral individuals with supervised research training in specified health and health-related areas leading toward the research degree (e.g., Ph.D.). |
The Role of the Androgen Receptor in Behavior @ Michigan State University
DESCRIPTION (provided by applicant): Hormone receptors in the brain, particularly the estrogen receptor, have been shown to play a major role in the development and maintenance of sex differences in behavior. However, the role of the androgen receptor in this process is less understood. Therefore I propose to investigate the role of the androgen receptor in two types of behavior, sensorimotor gating and anxiety, using male mice and rats with the testicular feminization mutation (TFM), a mutation in the androgen receptor gene that renders the protein nonfunctional. Experiment 1 will test the hypothesis that the androgen receptor is involved in the regulation of sensorimotor gating and anxiety-related behaviors in adulthood by comparing behavior between TFM males, wild type males and wild type females. Since TFM male mice and rats have different circulating testosterone (T) levels than their wild type siblings, in Experiment 2 all animals will be gonadectomized, administered T, and tested for the same behaviors to reveal whether circulating T is acting on AR in adulthood to affect behavior. Experiment 3 will test whether differences in sensorimotor gating and anxiety in adulthood are the result of androgen induced organization during development.
|
0.958 |
2019 |
Zuloaga, Damian Gabriel |
R15Activity Code Description: Supports small-scale research projects at educational institutions that provide baccalaureate or advanced degrees for a significant number of the Nation’s research scientists but that have not been major recipients of NIH support. The goals of the program are to (1) support meritorious research, (2) expose students to research, and (3) strengthen the research environment of the institution. Awards provide limited Direct Costs, plus applicable F&A costs, for periods not to exceed 36 months. This activity code uses multi-year funding authority; however, OER approval is NOT needed prior to an IC using this activity code. |
Sex Differences in Corticotropin Releasing Factor Receptor 1 Regulation of Stress-Associated Behaviors @ State University of New York At Albany
Project Summary There are striking sex differences in stress/mood associated disorders such as anxiety and depression with women showing 2-3 fold greater prevalence than men. These differences are postulated to be regulated by sex- specific patterns of gonadal hormone exposure and their subsequent effect on brain circuitry, although little is known about these sexually dimorphic circuits. Recent studies in our laboratory have uncovered two cell groups which show sex differences in expression of corticotropin releasing hormone receptor 1 (CRFR1) in the paraventricular hypothalamus (PVH; males>females) and anteroventral/rostral periventricular hypothalamus (AVPV/PeN; females>males). In rodents, corticotropin releasing factor signaling (CRF) through CRFR1 is known to regulate anxiety and depressive-like behaviors as well as stress hormone (adrenocorticotropic hormone (ACTH), glucocorticoid)) secretion, although the specific function of these sexually dimorphic nuclei are currently unknown. Aim 1.1 will determine the role of PVH and AVPV/PeN CRFR1 populations in stress-associated behaviors and hormone responses by pharmacologically ablating CRFR1 cells in these regions. This will be accomplished by utilizing stereotaxic injections of toxin that specifically destroys CRFR1 cells. Anxiety/depressive-like behaviors and ACTH/glucocorticoid responses to psychological stress will be assessed in these mice. In Aim 1.2 we will determine the functional connectivity of these two cell groups with other stress-regulating brain sites. These studies will utilize cutting edge tract tracing tools to assess downstream projection sites of CRFR1 cells that are engaged during psychological stress. Altogether, this aim will reveal specific anatomical populations involved in sexually dimorphic regulation of behavioral and hormonal stress functions. Aim 2 will determine the role of estrogen receptor alpha (ER?)-containing CRFR1 neurons in regulation of stress- associated functions by generating and testing a conditional knockout mouse line. Our preliminary data indicate that a high percentage of CRFR1 cells in the PVH and AVPV/PeN co-localize ER?. Furthermore, ER? is known to regulate anxiety/depressive behaviors and stress hormone release. Therefore, ER? may be a key receptor through which gonadal hormones can affect stress-related functions. Mice with conditional deletion of ER? will be compared to control mice in rodent tests of anxiety, depression, and stress-induced hormone release. This aim will reveal a specific cell phenotype involved in gonadal hormone regulation of stress-associated functions.
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0.958 |