2004 — 2005 |
Palomares, Melanie C |
F31Activity Code Description: To provide predoctoral individuals with supervised research training in specified health and health-related areas leading toward the research degree (e.g., Ph.D.). |
Visual Detection and Integration in Williams Syndrome @ Johns Hopkins University
DESCRIPTION (provided by applicant): I propose to characterize the basic visual abilities of children and adults with Williams Syndrome (WS), and of normally developing children. Williams Syndrome is a rare genetic disorder that has a distinct cognitive profile: a relative strength in language, but a profound weakness in visual-spatial cognition. This profile is of great interest because it suggests the possibility that genetic deficit might target specific cognitive systems, in this case, the system of spatial cognition. To date, most studies with WS have used complex visuo-motor tasks such as drawing or block construction to evaluate their visual-spatial abilities. Some have suggested that these deficits are not linked to "low-lever' visual functions such as stereopsis and acuity. However, very little is known about the abilities of WS in basic visual tasks. I plan to evaluate the possibility that the spatial cognitive deficits of WS are linked to important visual functions that allow integration of features over space. Using psychophysical tasks, I plan to look at how WS and normal controls detect a single object (e.g. detecting a grating at various spatial frequencies) as well as how they integrate multiple objects (e.g. detecting a contour made up of many gratings). These studies will give us a better understanding of how simple visual functions may contribute to complex spatial cognition deficits in WS, and perhaps provide insight into possible therapies that could ameliorate WS deficits. Furthermore, they will uncover the developmental trajectory of feature detection and feature integration in normal children.
|
0.905 |
2006 — 2009 |
Palomares, Melanie R |
M01Activity Code Description: An award made to an institution solely for the support of a General Clinical Research Center where scientists conduct studies on a wide range of human diseases using the full spectrum of the biomedical sciences. Costs underwritten by these grants include those for renovation, for operational expenses such as staff salaries, equipment, and supplies, and for hospitalization. A General Clinical Research Center is a discrete unit of research beds separated from the general care wards. |
Blood Tumor Markers For Molecular Diagnosis of Breast Disease and Monitoring @ University of Southern California |
0.935 |
2006 |
Palomares, Melanie R |
M01Activity Code Description: An award made to an institution solely for the support of a General Clinical Research Center where scientists conduct studies on a wide range of human diseases using the full spectrum of the biomedical sciences. Costs underwritten by these grants include those for renovation, for operational expenses such as staff salaries, equipment, and supplies, and for hospitalization. A General Clinical Research Center is a discrete unit of research beds separated from the general care wards. |
Phase I Prevention Trial of Activin Tm Grape Seed Extract as An Aromatase @ University of Southern California |
0.935 |
2007 |
Palomares, Melanie R |
M01Activity Code Description: An award made to an institution solely for the support of a General Clinical Research Center where scientists conduct studies on a wide range of human diseases using the full spectrum of the biomedical sciences. Costs underwritten by these grants include those for renovation, for operational expenses such as staff salaries, equipment, and supplies, and for hospitalization. A General Clinical Research Center is a discrete unit of research beds separated from the general care wards. |
Phase I Prevention Trial of Activin Tm Grape Seed Extract as An Aromatase Inhibi @ University of Southern California |
0.935 |
2008 — 2009 |
Palomares, Melanie R |
M01Activity Code Description: An award made to an institution solely for the support of a General Clinical Research Center where scientists conduct studies on a wide range of human diseases using the full spectrum of the biomedical sciences. Costs underwritten by these grants include those for renovation, for operational expenses such as staff salaries, equipment, and supplies, and for hospitalization. A General Clinical Research Center is a discrete unit of research beds separated from the general care wards. |
Clinical Trial: Phase I Prevention Trial of Activin Tm Grape Seed Extract as An @ University of Southern California
ADRGND; ActiVin (Grape Seed Extract); Activins; Adrenal Glands; Adrenals; Androstenedione Aromatase; Androstenedione Aromatase Inhibitor; Aromatase; Aromatase Cytochrome P450; Aromatase Inhibition; Aromatase Inhibitors; Assay; Bioassay; Bioavailability; Biologic Assays; Biologic Availability; Biological Assay; Biological Availability; Blood; Blood Serum; Breast Cancer Prevention; CRISP; CYP 19; CYP19 Protein; CYPXIX; Cancer of Breast; Chemoprevention; Clinical Trials; Clinical Trials, Unspecified; Computer Retrieval of Information on Scientific Projects Database; Contralateral; Cytochrome P-450 CYP19; Cytochrome P-450(AROM); Cytochrome P450 19; Cytochrome P450 19A1; Cytochrome P450, Family 19, Subfamily A, Polypeptide 1; Cytochrome P450, Subfamily XIX; Cytochrome P450, Subfamily XIX (Aromatization of Androgens); Diet Supplement; Dietary Supplements; Dose; Estrogen Synthase; Estrogen Synthase Inhibitor; Estrogen Synthetase; Estrogen Synthetase Inhibitor; Estrogenic Agents; Estrogenic Compounds; Estrogens; FSH-Releasing Protein; Funding; Grant; Human; Human, General; Institution; Investigators; Malignant Tumor of the Breast; Malignant neoplasm of breast; Man (Taxonomy); Man, Modern; Methods; NIH; National Institutes of Health; National Institutes of Health (U.S.); Nutritional Supplement; P450AROM; Pharmaceutical Agent; Pharmaceuticals; Pharmacologic Substance; Pharmacological Substance; Phase; Physiologic Availability; Placebo Control; Post-Menopause; Post-menopausal Period; Postmenopausal Period; Postmenopause; Prevention; Research; Research Personnel; Research Resources; Researchers; Resources; Reticuloendothelial System, Blood; SCHED; Safety; Schedule; Serum; Source; Standards; Standards of Weights and Measures; Symptoms; Therapeutic Estrogen; Translations; United States National Institutes of Health; Week; Woman; bioavailability of drug; bone metabolism; cancer risk; clinical investigation; grape seed extract; grapeseed extract; malignant breast neoplasm; mammary cancer prevention; mammary tumor prevention; post-menopausal; postmenopausal; suprarenal gland
|
0.935 |
2009 |
Palomares, Melanie R |
M01Activity Code Description: An award made to an institution solely for the support of a General Clinical Research Center where scientists conduct studies on a wide range of human diseases using the full spectrum of the biomedical sciences. Costs underwritten by these grants include those for renovation, for operational expenses such as staff salaries, equipment, and supplies, and for hospitalization. A General Clinical Research Center is a discrete unit of research beds separated from the general care wards. |
Clinical Trial: a Translational Breast Cancer Prevention Trial Mushroom Powder I @ University of Southern California
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a Phase I dose-finding study with objectives to show that a whole food extract of white button mushrooms (WBM) can inhibit aromatase-induced estrogen biosynthesis in postmenopausal breast cancer survivors (BCS), and to determine the optimal daily dose to induce this effect;and to determine the bioavailability of C-18 unsaturated fatty acids (CUFA), which are thought to moderate the anti-cancer effects of WBM. The secondary objectives of this study are to determine safety and tolerability of WBM in humans via serial comprehensive symptom questionnaires, pre- and post-treatment markers of bone metabolism, and pre- and post- treatment comprehensive lipid panels. To explore potential alternate anti- tumor mechanisms, specifically the effect of WBM on cytokines as well as innate and adaptive cellular immunity;and to describe barriers experienced in recruitment of ethnically diverse subjects from the community into a secondary prevention trial BCS utilizing a dietary supplement intervention, in an effort to enhance feasibility of a subsequent Phase II trial.
|
0.935 |
2010 — 2012 |
Palomares, Melanie C |
R13Activity Code Description: To support recipient sponsored and directed international, national or regional meetings, conferences and workshops. |
Opam: a Conference On Object Perception Attention and Memory @ University of South Carolina At Columbia
DESCRIPTION: In everyday experience, we effortlessly recognize faces, objects and scenes, yet the mechanisms underlying how we perceive the world remain elusive. Moreover, it is unclear how cognitive processes such as selective attention and memory interact with object recognition. The conference on Object Perception Attention and Memory (OPAM) is a one-day conference that showcases young investigators (i.e. undergraduate, graduate and post-doctoral trainees) and their theoretical and empirical work on object processing in terms of attention, perception and memory. In addition, this conference highlights different methodological approaches to understand object processing including psychophysics, neuroimaging and neuropsychology. The goal of OPAM is three- fold: (1) to foster scientific research from junior investigators, (2) to facilitate interactions between junior and senior investigators, and (3) to provide a venue for a concentrated discussion on the role of attention and memory on object perception. PUBLIC HEALTH RELEVANCE: This conference will enhance our understanding of how attention and memory intersect with object and scene perception through fresh perspectives from junior investigators. The knowledge gained from discussions of basic research give rise to the development of clinical tools -- new ways to measure or diagnose deficits in object and scene perception. It also provides insight into therapies that might ameliorate perceptual, attention or memory deficits in special populations such as ADHD, autism, Williams Syndrome, Fragile X Syndrome and dyslexia. 2
|
0.958 |