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High-probability grants
According to our matching algorithm, Chad J. Swanson is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
1999 — 2000 |
Swanson, Chad J |
F31Activity Code Description: To provide predoctoral individuals with supervised research training in specified health and health-related areas leading toward the research degree (e.g., Ph.D.). |
Group I Mglurs and Cocaine Sensitization @ Medical University of South Carolina
DESCRIPTION Sensitization to psychostimulants upon repeated administration involves enduring biochemical changes that underlie an augmented behavioral output. These long-term changes manifest within the nucleus accumbens (NA), in part, as enhanced dopaminergic neurotransmission that is implicated in psychostimulant-induced paranoid psychosis and drug relapse in recovering addicts. The role that specific metabotropic glutamate receptor (mGluR) sub-groups play in this event is unclear. The proposed studies herein are intended to investigate group I mGluR involvement in the lasting behavioral and biochemical changes seen in cocaine sensitization. This will be accomplished by conducting the following studies at both 24 hours (early) and 3 weeks (late) withdrawal from drug administration: 1) Investigation of the role that group I mGluRs play in behavioral expression of cocaine sensitization; 2) Analysis of protein changes in mGluR1 and mGluR5 as well as group I-associated regulatory proteins Homer 1a and homer 1 b/c in brain regions pertinent to cocaine sensitization. These studies will examine potential biochemical correlates to the behavioral response demonstrated above; and 3) Assessment of the ability of group I mGluRs to elevate intracellular IP3 level in sensitized animals. These studies will offer insight into the functional regulation of intracellular mechanisms associated with Group I mGluRs in animals sensitization to cocaine. Taken together, results obtained from this proposal may divulge possible novel pharmacological interventions in the treatment of drug-induced neurological aberrations.
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