Area:
Microcircuitry, Song System
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High-probability grants
According to our matching algorithm, Mark N. Miller is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
2006 — 2008 |
Miller, Mark Nathaniel [⬀] |
F31Activity Code Description: To provide predoctoral individuals with supervised research training in specified health and health-related areas leading toward the research degree (e.g., Ph.D.). |
Functional Microcircuitry of Corticostriatal Projections
[unreadable] DESCRIPTION (provided by applicant): The striatum is critically involved in the planning and execution of directed movement, and numerous neurological disorders are closely associated with striatal dysfunction. Despite a detailed understanding of striatal cellular and circuit function, and compelling evidence that striatal function is to a large extent governed by highly structured corticostriatal input, the intracortical mechanisms responsible for shaping and providing this input remain unknown. I propose to elucidate these mechanisms by characterizing the intrinsic membrane properties and morphologies of the two major corticostriatal layer V pyramidal populations, determine whether they, like some other pyramidal cell classes, form subnetworks of preferential homotypic connections, and whether they are subject to differential local inhibition. Results from these experiments will not only clarify the cortical determinants of corticostriatal activity but, by asking whether functionally related layer V pyramidal cells form distinct or overlapping local networks, will also provide insight into the principles of cortical circuit organization. [unreadable] [unreadable] [unreadable]
|
0.954 |
2011 — 2013 |
Miller, Mark Nathaniel [⬀] |
F32Activity Code Description: To provide postdoctoral research training to individuals to broaden their scientific background and extend their potential for research in specified health-related areas. |
Synaptic Plasticity Underlying Vocal Learning @ University of California, San Francisco
DESCRIPTION (provided by applicant): Sensorimotor learning allows organisms to interact adaptively with their environment, yet a detailed description of how sensory input modifies motor circuitry during learning has not been developed. Since many movement disorders involve dysfunction of motor planning and disruption of learned motor programs, understanding how motor programs are instantiated in motor circuits during learning is essential. Vocal learning in songbirds is a particularly tractable model of sensorimotor learning since birdsong is an ethological and readily quantifiable behavior, and because the neuroanatomical substrates of song production are identified and accessible. Song learning entails the convergence of juvenile song toward a tutor song, and although changes in song are associated with changes in premotor nuclei, the synaptic and cellular plasticity mechanisms underlying song learning remain unknown. This proposal describes experiments that will combine a form of rapid song learning with chronic in vivo electrophysiology in behaving animals to identify patterns of premotor activity that accompany changes in song, and utilize in vitro whole-cell recording and minimal stimulation to identify the synaptic loci and mechanisms of this plasticity. Results from these experiments will provide an integrated and comprehensive account of vocal motor learning, from synaptic plasticity to changes in circuit dynamics to altered vocal behavior, and thereby give broad insight into how the nervous system learns adaptive and complex behaviors. PUBLIC HEALTH RELEVANCE: The experiments in this proposal will elucidate the detailed changes in brain circuitry that underlie learning of a complex motor task. Many neurological disorders involve dysfunction of brain circuits that control motor behavior, and understanding how motor behavior is encoded by neurons in motor circuits would provide important insight into how these circuits produce disrupted behaviors in disease states.
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1 |