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High-probability grants
According to our matching algorithm, Edmund G. Anderson is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
1985 — 1987 |
Anderson, Edmund G |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Serotonergic Regulation of Primary Afferents @ University of Illinois At Chicago
The long range objective is to understand how bulbospinal serotonergic neurons regulate sensory input. This understanding is sought in terms of the specific mechanisms by which this system regulates motor reflexes and pain perception. In addition, specific sites for pharmacological attack on the serotonergic regulation of sensory perception will be defined. The initial goal is to determine how serotonin (5-HT) directly affects primary afferent transmission. This understanding is sought both in terms of the characteristics of the membrane receptors on which 5-HT acts, as well as the neuronal sites and membrane permeability changes by which the effect is mediated. The initial approach will use intracellular recording from primary afferent cell bodies to study the membrane effects of directly applied 5-HT. The receptors mediating these effects will be characterized by their agonist and antagonist selectivity defined using dose-response criteria. The presence of receptor coupling to the adenylate cyclase system will be explored. With the pharmacological probes, defined in the above experiments, the effects of 5-HT on primary afferent transmission will be pursued in the isolated hemisected frog spinal cord and the in vivo rat spinal cord. Changes in the size of the excitatory post synaptic potential (EPSP) will be used as an index of the presynaptic action of the 5-HT agonists. From these data, mechanisms for 5-HT modulation of pre-synaptic modulation should emerge. We have observed that various primary afferent cell bodies exhibit differing spectra of membrane responses to 5-HT and the sensory modality of the cell will be investigated in situ. An intact rat preparation will be used where intracellular recordings from DRG cells still connected with their peripheral receptors can be made. The sensory modality of the peripheral receptors can then be compared with the nature of the membrane responses to 5-HT. From these observations we can determine if 5-HT selectively inhibits and/or facilitates specific sensory modalities.
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1 |
1993 — 1994 |
Anderson, Edmund G |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Multiple Serotonin Receptors On the Same Cell @ University of Illinois At Chicago
The long-term objective is to understand how multiple serotonin receptors, present on the same dorsal root ganglion cell, interact to synthesize a meaningful signal. To date, evidence indicates that 5-HT2 and 5-HT3 receptors co-occur on A-type cells, and that 5-HT1A and 5-HT(2 or 3) receptors are colocalized on C-type cells of the primary sensory neurons. The problem to be solved is how seemingly conflicting effects (e.g. co-occurrence of receptors that increase and decrease membrane conductance, or that depolarize and hyperpolarize the membrane) are integrated into a coherent signal. It is hypothesized that integration of multiple receptor signals is accomplished by second messenger cross-talk. Using a combination of current-clamp, voltage-clamp and patch-clamp methodologies on acutely isolated dorsal root ganglia or their dissociated cells, the ion currents affected by each 5-HT receptor subtype will be identified. Then, by use of pharmacological probes, the role of various known second messengers in transducing or modulating the ion current(s) associated with each receptor subtype will be characterized. Once the ion current(s) and the second messenger roles have been described for each receptor subtype, the interactions between receptor subtypes will be explored. Whenever it is observed that one receptor subtype will augment or impede the effect of another receptor subtype present on the same cell, the role of second messengers in that interaction will be characterized. The understanding of how one receptor subtype modulates the response of another receptor subtype on the same cell would markedly increase our ability to pharmacologically manipulate that cells responsiveness. With respect to the dorsal root ganglion cells, this understanding would increase opportunities for gaining selective pharmacological control over sensory input, including pain and motor reflexes. In addition, other cell systems in the brain contain multiple 5-HT receptor subtypes, and the principles established by this investigation have potential application in the larger area of serotonin pharmacology.
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