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High-probability grants
According to our matching algorithm, Hemanth P. Nair is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
1998 — 2000 |
Nair, Hemanth P |
F31Activity Code Description: To provide predoctoral individuals with supervised research training in specified health and health-related areas leading toward the research degree (e.g., Ph.D.). |
Brain Imaging of Developmental Learning Effects @ University of Texas Austin
DESCRIPTION (Adapted from applicant's abstract): The aim of the proposed research is to combine brain metabolic mapping and structural equation modeling, a statistical path analysis technique, to study postnatal maturation of the functional interactions of neural systems related to reinforcement, memory, and behavioral inhibition in the preweanling rat. In the proposed experiment, preweanling pups at 16-17 and 11-12 days of age will be trained, in a straight alley runway, on two reward schedules, patterned single alternation (PSA) and random partial reinforcement (PRF). Following training on these schedules, animals will be injected with fluorodeoexyglucose (FDG), a radio labeled glucose analog and then given 50 trials of extinction training, i.e. continuous non-reward. Immediately following training, they will be sacrificed and their brains processed for FDG. Glucose utilization in a number of brain regions will be quantified using image analysis sofware. Structural equation modeling will be applied to these data to quantify functional influences between anatomically connected brain regions. The network models derived from this process from PSA and PRF groups at each age will be compared. PSA and PRF comparisons in the 16-17 day old age group should reveal functional differences in the coordinated function of brain regions between animals demonstrating behavioral inhibition and perserveration, respectively. Comparison of 16-17 day old PSA and PRF groups to their 11-12 day old counterparts should reveal ontogenetic differences in brain activity related to the behavioral differences across the two ages. Handled controls will be included to control for brain activation related to handling and not learning per se. The major goal of this work is to contribute substantially to the understanding of metabolic maturation of brain regions related to reinforcement, memory, and behavioral inhibition, and how changes in their coordinated activity during postnatal development are reflected in behavior.
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1 |
2003 — 2004 |
Nair, Hemanth P |
F32Activity Code Description: To provide postdoctoral research training to individuals to broaden their scientific background and extend their potential for research in specified health-related areas. P51Activity Code Description: To support centers which include a multidisciplinary and multi-categorical core research program using primate animals and to maintain a large and varied primate colony which is available to affiliated, collaborative, and visiting investigators for basic and applied biomedical research and training. |
Crf-R1 Mediation of Fear: a Viral Vector Approach
DESCRIPTION (provided by applicant): Previous research has demonstrated that while conditioned fear may rely predominantly on the central nucleus of the amygdala (CEA), responses to less predictable or unconditioned anxiogenic stimuli, or fear states akin to anxiety may depend on the bed nucleus of the stria terminalis (BNST). Furthermore, this dissociation may be related to CRF type I (CRF-RI) receptor activity in the two regions. The major goal, and second specific aim of this proposal is to use a lentiviral vector to over-express the CRF-R1 receptor in the BNST or CEA of adult rats and assess its effects on different forms of facilitation of the acoustic startle reflex, a measure of fear. The hypothesis is that over-expression in the CEA will facilitate fear-potentiated startle; a form of conditioned fear, and over-expression in the BNST will facilitate baseline acoustic and light-enhanced startle, measures of general stress/anxiety and unconditioned fear, respectively. These studies assume that over-expression of a receptor is rate limiting. They also depend on a localized and sustained expression of the CRF-R1 transgene. Therefore, the first specific aim is to a) assess whether viral mediated increases in CRF-R1 receptors will change binding and cAMP levels in vitro, B) characterize in-vivo the spread of virus following injection and C) characterize the time course of expression. The proposed studies aim to contribute to our understanding of the neurological basis of anxiety disorders or disorders of fear (e.g. post-traumatic stress disorder).
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0.966 |