Ran Blekhman, Ph.D. - US grants
Affiliations: | 2010 | Human Genetics | University of Chicago, Chicago, IL |
Area:
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The funding information displayed below comes from the NIH Research Portfolio Online Reporting Tools and the NSF Award Database.The grant data on this page is limited to grants awarded in the United States and is thus partial. It can nonetheless be used to understand how funding patterns influence mentorship networks and vice-versa, which has deep implications on how research is done.
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High-probability grants
According to our matching algorithm, Ran Blekhman is the likely recipient of the following grants.| Years | Recipients | Code | Title / Keywords | Matching score |
|---|---|---|---|---|
| 2018 — 2021 | Blekhman, Ran | R35Activity Code Description: To provide long term support to an experienced investigator with an outstanding record of research productivity. This support is intended to encourage investigators to embark on long-term projects of unusual potential. |
Population Genomics of Host-Microbiome Interactions @ University of Minnesota Population Genomics of Host-Microbiome Interactions The composition of the microbial communities that colonize the human body varies widely across individuals and populations, and has been associated with numerous host traits and diseases. Although the microbiome is influenced by environmental factors, a strong host genetic factor is also expected to control the interaction between humans and the microbiome. Understanding the relative role of genetic and environmental factors in host-microbiome interactions is a central goal in human disease research. However, we know very little about the genomic factors that control the interaction between humans and the microbiome and their effect on complex human disease. It is often difficult to disentangle genetic from environmental effects on the microbiome, and studies only consider the microbiome in a single time point, which could be problematic given the microbiome can vary dramatically day-to-day and throughout an individual's life. Moreover, as most microbiome studies identify correlations, we do not know how inter-individual and inter-population variation in microbiome composition affects host physiology. In this proposal, I outline a long-term research strategy to address these critical gaps in knowledge. Research in my lab is based on the hypothesis that the microbiome can be considered a quantitative trait, and thus we can directly map host genomic factors controlling the variation in the microbiome, as well as identify individual host genes and pathways that are regulated by the microbiome. Here, I outline my lab's research program for the next five years, designed to answer fundamental questions about the genetic basis of host- microbiome interactions via three broad, complementary Project Areas, aiming to: (1) collect and integrate host and microbiome genomic data to achieve a systems-level understanding of host-microbiome molecular interactions in the colon; (2) characterize the heritability of life-long longitudinal microbiome dynamics in a primate model system; and (3) use novel in vitro and ex vivo systems to understand the effect of inter- population variation in the microbiome on host gene regulation and describe the underlying regulatory mechanism. The proposed research program will provide a systems-level view of the molecular interactions between host genes and microbial taxa, genes, and pathways in the gut; a characterization of how microbiome dynamics and taxa are controlled by host genetic variation; and a description of the mechanism with which the microbes regulate host genes. These results would transform our understanding of the interplay between human genomics and the microbiome, explain how this interaction affects disease, and would enable development of microbiome-based therapeutics and diagnostics that improve human health. |
0.964 |
| 2021 | Blekhman, Ran Greenstein, David Irwin [⬀] |
T32Activity Code Description: To enable institutions to make National Research Service Awards to individuals selected by them for predoctoral and postdoctoral research training in specified shortage areas. |
An Interdisciplinary Training Program to Transform Graduate Education in Genetics and Genomics @ University of Minnesota PROJECT SUMMARY Genetics is a foundational discipline central to biomedical research and clinical practice. Our mission is to train geneticists for the 21st century. To achieve this goal, we have designed and implemented an interdisciplinary training program to transform graduate education in genetics and genomics at the University of Minnesota. Our Specific Aims are: (i) to provide students with rigorous and quantitative training in the fundamentals and state- of-the-art advances in genetics, genomics, and computational biology; (ii) to leverage the many collaborative research and educational strengths of our institution to provide new interdisciplinary student-centered graduate training opportunities that transcend departmental and collegiate boundaries; and (iii) to generate a diverse cohort of well-trained scientists able to integrate their broad skillset and their hunger for lifelong learning into their work across a multitude of careers in the biomedical workforce. This program will enable trainees to pursue many impactful career opportunities in academia, biotechnology, government, health care, or education created by recent advancements in genetics and genomics, including careers in fields that are undergoing rapid change, as well as careers in areas that do not presently exist or that are nascent. In recognition of the fact that the geneticists of tomorrow must possess quantitative acumen, we have not only developed new courses emphasizing bioinformatics and computational approaches, but we have also integrated these into our training program through a major redesign of the graduate curriculum pursuant to evaluation by internal and external review panels. In a sense, genetics and genomics are foundational fields that transcend and unify multiple disciplines within the biological sciences because what sets living things apart from inanimate objects is that all living things possess within them molecular blueprints for their construction, genomes. An impactful aspect of this academic and research training program is that it seeks to transcend traditional departmental boundaries by bringing together researchers from multiple disciplines within the biomedical sciences who utilize genetic and genomic analyses in their research. In so doing, this training program seeks to promote interdisciplinary research, foster collaborative team science, and implement individualized student-centered educational and career development programs. Our training program includes 50 highly productive and collaborative faculty from ten departments across five colleges at the University of Minnesota. We are seeking support for six PhD trainees for two years each beginning in year two of their academic program, with funding for year one provided by institutional funds. In addition to their thesis research, trainees will participate in professional development programs aimed at promoting their transition into and long-term success in biomedical science-related careers. |
0.964 |