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High-probability grants
According to our matching algorithm, Courtney M. Cameron is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
2010 — 2012 |
Cameron, Courtney Marie |
F31Activity Code Description: To provide predoctoral individuals with supervised research training in specified health and health-related areas leading toward the research degree (e.g., Ph.D.). |
The Role of Accumbens Rapid Dopamine Signaling in Sucrose and Cocaine Seeking @ Univ of North Carolina Chapel Hill
DESCRIPTION (provided by applicant): Targeting behaviors to successfully obtain rewards is an essential aspect of survival. In order to execute goal-directed behaviors, organisms must integrate information about their environment into motivated actions. However, in humans, unnatural rewards such as drugs of abuse can often come to take the place of natural rewards, leading to aberrant motivational processing. The performance of these goal-directed behaviors likely involves the concerted activation of specific brain regions and neurotransmitter systems. The nucleus accumbens (NAc) and its dopaminergic inputs form a key brain circuit for processing the reinforcing aspects of both natural and drug rewards. This proposal seeks to examine neurochemical activity in the NAc during the execution of goal-directed behaviors. Fast-scan cyclic voltammetry (FSCV) will be employed to measure changes in sub-second dopamine release in the NAc during a self-administration task for both sucrose and cocaine. Additionally, FSCV will be used to examine alterations in dopamine signaling following abstinence from cocaine self-administration. The results of these studies will provide insight into the factors influencing neurochemical signaling during the pursuit of natural as well as drug rewards. PUBLIC HEALTH RELEVANCE: Drug addiction is a pervasive public health issue for both individuals and their communities. Often, addicts are able to abstain from drug use for extended periods of time, only to relapse after encountering environments or situations previously associated with drug taking. This proposal seeks to examine the neurochemical factors mediating drug seeking behaviors, with a specific emphasis on the role of drug abstinence, and, therefore, will provide key information for the development of pharmacological treatments for drug addiction in humans.
|
0.988 |
2017 — 2019 |
Cameron, Courtney Marie |
F32Activity Code Description: To provide postdoctoral research training to individuals to broaden their scientific background and extend their potential for research in specified health-related areas. |
Clarifying the Role of a Corticolimbic Projection in Cocaine-Seeking
Project Summary Relapse to drug use even after extended periods of abstinence is a major obstacle in the rehabilitation of cocaine users. In rodents, experiments have consistently demonstrated that drug-seeking behavior, such as responding for cocaine-associated cues, progressively increases following abstinence from cocaine. A better understanding of the circuitry that underlies these abstinence-induced increases in drug-seeking behavior will be critical in developing hypothesis-driven therapeutic strategies for the prevention of relapse. Given the loss of control often observed in addiction, the prefrontal cortex, which exerts ?top-down? control on many downstream structures, has received a great deal of attention. However this region is highly heterogeneous, composed of many different neuronal subpopulations each with distinct patterns of afferent and efferent projections. To date, it has been difficult to ascertain what information is being encoded by projection-defined subpopulations during drug-seeking behavior, as well as how these populations contribute causally to increased drug-seeking following abstinence. The subpopulation of infralimbic (IL) neurons that project to the nucleus accumbens (NAc) is of particular interest, given the role of both of these structures in increased drug-seeking following abstinence. The proposed NRSA research plan will clarify the contribution of NAc-projecting IL neurons to increased cocaine-seeking behavior following abstinence by recording and manipulating activity specifically in this subpopulation of neurons. Specific Aim 1 will use cellular resolution calcium imaging to identify neural correlates of IL?NAc projecting neurons in rats during an extinction session to assess cue-induced cocaine- seeking. Behavior and neural correlates will be compared between rats before and after cocaine abstinence. Specific Aim 2 will use optogentics to examine the causal contribution of the IL?NAc projection to increased cocaine-seeking following abstinence. Rats will be trained to self-administer cocaine, and IL?NAc neurons will be optogenetically activated on a subset of trials during an extinction session to test cue-induced drug-seeking before or after prolonged abstinence. Drug-seeking will be compared between trials in which this pathway is activated versus trials in which it is not. By combining correlational and causal techniques, this research has the potential to provide novel insights for the development of relapse prevention therapies in clinical populations.
|
0.951 |