We are testing a new system for linking grants to scientists.
The funding information displayed below comes from the
NIH Research Portfolio Online Reporting Tools and the
NSF Award Database.
The grant data on this page is limited to grants awarded in the United States and is thus partial. It can nonetheless be used to understand how funding patterns influence mentorship networks and vice-versa, which has deep implications on how research is done.
You can help! If you notice any innacuracies, please
sign in and mark grants as correct or incorrect matches.
Sign in to see low-probability grants and correct any errors in linkage between grants and researchers.
High-probability grants
According to our matching algorithm, Christopher R. Hayworth is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
2017 |
Hayworth, Christopher Roy |
R03Activity Code Description: To provide research support specifically limited in time and amount for studies in categorical program areas. Small grants provide flexibility for initiating studies which are generally for preliminary short-term projects and are non-renewable. |
Multimodal Imaging of Neuronal and Glial Contributions to Sleep Homeostasis in Vivo @ Washington State University
Project Summary The Centers for Disease Control and Prevention have stated that insufficient sleep is an epidemic that poses significant clinical and economic impacts. Poor sleep can be caused by impaired sleep homeostasis which regulates sleep need as a function of prior wakefulness. Therefore, determining the cellular basis of sleep homeostasis is necessary to understand the underlying causes of abnormal sleep. The biological substrates of sleep homeostasis are incompletely understood, but neuronal-glial feedback mechanisms may play a central role. Because neuronal and astroglial chemical signaling is mediated, in part, by intracellular calcium waves, we hypothesize that neuronal and astroglial intracellular calcium dynamics contribute to the accumulation and discharge of sleep need. This hypothesis will be tested using a multimodal imaging approach to measure in vivo intracellular calcium activity in neuronal and astroglial somata and processes. Genetically encoded calcium indicators will be selectively expressed in neurons or in astrocytes to assess intracellular calcium dynamics using two microscopy methodologies in the same, unanesthetized mouse: 1) a lightweight, head-mounted epifluorescent microscope that permits free movement and behavior and 2) two-photon microscopy combined with a platform that allows for head-restrained cage navigation. Cellular calcium dynamics will be simultaneously recorded with sleep-wake behavior, as determined by electroencephalography and electromyography, under physiological conditions and in response to sleep deprivation. Thus, this project will develop a scalable platform methodology for the functional assessment of different brain cell types in freely behaving and unanesthetized animals. Our approach integrates complementary microscopy techniques with standard behavioral analyses for the assessment of neuronal and glial activity during complex processes and behavior. As such, the proposed design can be extended to studies of addiction, aging, learning and memory, and more to further elucidate the underlying neurobiology of centrally mediated processes and behaviors.
|
0.952 |