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High-probability grants
According to our matching algorithm, Jaime Olavarria is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
1992 — 1995 |
Olavarria, Jaime F |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Functional Pathways in Visual Area V2 @ University of Washington
Primate visual cortex is subdivided into a number of visual areas that are hierarchically interconnected, and many of these areas are in turn subdivided into smaller, modular subregions. The long-term goal of this proposal is to contribute to our understanding of how visual information is processed by these subdivisions of visual cortex. The general strategy is to relate pathways interlinking specific sets of visual areas and subregions with functional streams specialized in the analysis of specific aspects of visual information. The project focuses on visual area V2, which contains a sequence of alternating stripe-like subregions revealed with cytochrome oxidase histochemistry (thick and thin stripes, and interstripes). A number of complementary anatomical and physiological experiments are proposed to address several issues bearing on the relationship of this modular organization with functional streams in visual cortex. The cortex will be physically unfolded and flattened to relate the anatomical and physiological data to the pattern of stripes over large regions of V2. One set of experiments will use electrophysiological and 2-deoxyglucose techniques to investigate the organization of the snipe pattern with respect to the visual field, paying especial attention to how dorso- ventral asymmetries in the stripe pattern are reflected in the topographic map. In addition, the possibility that each class of stripes has its own map of the visual field will be explored in detail. A second set of experiments will study specific cortical and subcortical connections of V2 in an effort to characterize further the degree of independence, or intermixing, of the processing pathways represented by the V2 stripe subregions. Results from this project will significantly extend our knowledge about functional visual pathways in normal individuals. They may also yield valuable clues for interpreting pathological conditions such as trauma and tumors involving cortical areas, and for designing treatment and artificial ways for aiding vision-impaired subjects.
|
0.958 |
2005 — 2006 |
Olavarria, Jaime F |
R03Activity Code Description: To provide research support specifically limited in time and amount for studies in categorical program areas. Small grants provide flexibility for initiating studies which are generally for preliminary short-term projects and are non-renewable. |
Development of Visual Cortical Projections in Mammals @ University of Washington
[unreadable] DESCRIPTION (provided by applicant): Identifying the factors that guide the development of organized connections in the cerebral cortex is crucial for preventing and treating neurological disorders resulting from abnormal development of neuronal circuits. This project stems from the realization that our knowledge of the development of cerebral circuits lags behind that acquired in living animals through the use of modern time-lapse imaging techniques. For instance, in Xenopus tadpoles, these techniques revealed highly dynamic phenomena involving the addition and retraction of small axon branches. These rapid phenomena may be critical for the formation of organized neural projections. In contrast, virtually all we know about the development of organized cortical circuits in mammals comes from studies using fixed tissue. The main goal of this project is to introduce the use of high resolution time-lapse imaging methods to the study of developing cortical projections in mammals. We will use acute slices of rat visual cortex to analyze the behavior of anterogradely labeled axons growing from area 17 to ipsilateral area 18. We chose this in vitro approach because at present there is no better alternative for observing the development of organized cortical projections in living mammalian tissue. Our preliminary time-lapse observations revealed a surprising level of activity in the form of branch additions and retractions that could not have been predicted using fixed tissue. We propose three experiments to examine this dynamic axon branch behavior at specific sites associated with critical events during the formation of organized cortical projections. If successful, our model will focus attention on the role that dynamic remodeling phenomena have in the development of cortico-cortical projections in mammals. Moreover, by allowing experimental manipulations that are not presently possible in living mammals, we expect that our model will advance our understanding of the cellular and molecular mechanisms underlying the development of cortical projection maps. [unreadable] [unreadable]
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0.958 |