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High-probability grants
According to our matching algorithm, Robert A. McCrea is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
1985 |
Mccrea, Robert A. |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Morphophysiology of Vestibulo-Ocular Pathways
The overall aim of the proposed studies is to determine the physiological and morphological characteristics of vestibular neurons pathways which are involved in controlling eye movement in the squirrel monkey; particularly in the horizontal plane. Ther specific aims of the proposal are to: 1) determine the morphology, axonal projections and physiological characteristics of vestibular neurons which are directly involved in the horizontal vestibuloocular reflex (VOR), or which project directly to the abducens nucleus or the medial rectus subdivision of the oculomotor nucleus. 2) To determine the location, dendritic morphology, axonal projections and physiological characteristics of type II vestibular neurons, to delineate the morphological classes of type II neurons, and to study the physiological activity of each class in respect to vestibular and visual stimuli and to eye movements. 3) To study the morphology and physiological activity of other classes of vestibular neurons whose activity is modulated during horizontal head acceleration and/or horizontal eye movements. The methods to be used in the proposed studies include anatomical tracer methods, and intracellular recordings and horseradish peroxidase injections into physiologically identified vestibular neurons in anesthetized and alert squirrel monkeys. The results of these studies are expected to increase our knowledge of the anatomical and physiological characteristic of central vestibular neurons and pathways, and in general our understanding of the brainstem control of vestibular and oculomotor functions.
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1 |
1987 — 1989 |
Mccrea, Robert A. |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Morphophysiology of Cerebellar-Vestibular Pathways
neurophysiology; vestibular pathway;
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1 |
1989 — 2007 |
Mccrea, Robert A. |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Physiology of Oculomotor Premotor Pathways
DESCRIPTION (provided by applicant): The aim of the proposed studies is to study the firing behavior of afferent inputs to the vestibular nuclei that are influential in modifying signal processing in vestibulo-ocular reflex (VOR) pathways during smooth tracking head movements and during near viewing. The initial studies will focus on the contribution of cerebello-vestibular pathways to these functions. Other possible sources of vestibular nucleus afferent inputs that modify signal processing in VOR pathways as a function of behavioral context will be considered if the cerebello-vestibular pathways do not appear to be sufficient to suppress the VOR during active head movements or for modifying signal processing in VOR pathways during near viewing. The first specific aim is to determine the source and characteristics of the head movement efference copy inputs to the vestibular nuclei that cancel or attenuate vestibular signals on secondary VOR neurons during gaze pursuit. Monkeys will be trained to pursue targets moving in the horizontal plane using smooth movements of the eye, head and/or body. Unit responses during active and passive movements will be compared. Regions of the cerebellum and brainstem that contain cells that are differentially sensitive to active head movements will be investigated further using electrical stimulation and chemical inactivation techniques. Anatomical studies will be carried out using retrograde tracers in combination with localized marking of recording sites to determine whether regions containing active head movement cells also project to the vestibular nuclei. The second specific aim is to determine the contribution of the cerebellar flocculus to viewing distance related changes in the angular and linear VOR during passive and active head movements. Monkeys will be trained to fixate or pursue visual targets presented on an earth stationary display mounted on a motorized track so that its distance can be varied from 10-150 cm. Vestibular stimuli will consist of passive whole body angular rotation or linear translation in head-restrained monkeys. Single unit recordings will be obtained from flocculus Purkinje cells and secondary VOR neurons. Unit responses to passive and active whole body motion at different viewing distances and target eccentricities will be recorded. The contribution of the flocculus to viewing distance related changes in the VOR will be assessed by examining the viewing distance related changes in the responses of Purkinje cells and VOR pathway neurons. Vestibular nucleus neurons that receive inputs from the cerebellar flocculus will be identified by electrical stimulation of the flocculus. Particular attention will be paid to determine whether different Purkinje cells are differentially sensitive to the movements of one or both eyes or to heave or thrust translation. The neurophysiological observations will be evaluated in the context of the observed effects of unilateral or bilateral inactivation of the cerebellar flocculus on the angular and linear VOR. The results should increase our understanding of the central mechanisms that allow clear vision of objects in a 3D environment during passive and active head movements.
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1 |
2001 — 2005 |
Mccrea, Robert A. |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Physiology of Vestibulo-Thalamic Pathways
DESCRIPIION(provided by applicant)Sensory vestibular signals are transformed in the vestibular nuclei aboutn a vartety of ways. The nature of transformation depends on the type of vestibular nucleus neuron and the behavioral context. The goals of proposed studies are 1) to determine the dynamic characteristics and coordinate frame(s) of the angular linear self-motion signals carried by vestibulo-thalamic pathways and 2) to determine how these self-mo about signals change as a function of behavioral context. Single unit recordings will be obtained fi orthodromically identified secondary vestibular neurons that project to the thalamus. The focus will be units whose firing behavior is related to horizontal rotation and/or translation in the horizontal plane. interaction of vestibular signals with visual self-motion signals will be studied by comparing unit response passive movement in the dark with responses evoked in a lighted surround or during viewing of target, different distances. The interaction of vestibular signals with proprioceptive estimates of self-motion wil] studied by comparing unit responses to passive movement in the dark with responses evoked when the hea about held stable in space and the body is moved, or the platform that serves as the support surface is moved. 1 self motion signals produced by vestibulo-thalamic neurons during passive and active movements will compared signals produced during smooth tracking head movements. Different combinations of act rotational and translational head movements will be examined. In some conditions the head will be free move in the plane of the horizontal semicircular canal and in others it will be restrained from moving respect to the body or with respect to the turntable. The results will add to our fundamental understandin about how multimodal sensory signals are integrated in ascending vestibular sensory pathways, and how they modified in different behavioral contexts. Such knowledge should be useful in the development countermeasures for the profound changes in sensory processing of vestibular sensory information in elde people who suffer from a progressive loss of vestibular function.
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