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High-probability grants
According to our matching algorithm, Douglas G. Wallace is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
2006 |
Wallace, Douglas |
R15Activity Code Description: Supports small-scale research projects at educational institutions that provide baccalaureate or advanced degrees for a significant number of the Nation’s research scientists but that have not been major recipients of NIH support. The goals of the program are to (1) support meritorious research, (2) expose students to research, and (3) strengthen the research environment of the institution. Awards provide limited Direct Costs, plus applicable F&A costs, for periods not to exceed 36 months. This activity code uses multi-year funding authority; however, OER approval is NOT needed prior to an IC using this activity code. |
Role of the Cholinergic System in Spatial Orientation @ Northern Illinois University
[unreadable] DESCRIPTION (provided by applicant): Spatial orientation depends on the integrity of multiple neural systems. Acute or chronic neurological conditions that disrupt any of these systems can produce profound impairments in an individual's ability to remain spatially oriented within an environment. The lack of an effective treatment for Topographical Disorientation (TD), in combination with an aging population in which a growing number of individuals will be at risk for sustaining a stroke or developing AD, presents serious challenges for society in the management of these patients. Developing a treatment for TD will depend on the identification of an appropriate animal model of spatial orientation and the application of this model to investigate the contribution of specific neurotransmitter systems to spatial orientation. Previous work examining the neural basis of spatial orientation has focused on the use of navigational strategies that depend on landmarks in the environment; however, humans also use navigational strategies that are independent of environmental landmarks. The choice of navigational strategy depends on cue availability and environmental familiarity. The experiments outlined in this proposal continue a research program investigating the neural basis of spatial orientation The following goals were developed to establish the role of the cholinergic system in spatial orientation: 1) investigate the ability of the rodent model to dissociate the effects of cholinergic deafferentation of the hippocampus and cortex on spatial orientation, 2) examine the effectiveness of cholinergic treatments on restoring spatial orientation, 3) investigate the role of intact brain structures in mediating the recovered spatial orientation observed subsequent to cholinergic treatments. Establishing that cholinergic deafferentation fractionates the navigational strategies that are critical for spatial orientation reflects a novel framework for understanding TD. These studies will advance our understanding of the neural basis of spatial orientation, and the results may have implications for developing treatments for TD. [unreadable] [unreadable]
|
0.915 |
2018 |
Wallace, Douglas |
R15Activity Code Description: Supports small-scale research projects at educational institutions that provide baccalaureate or advanced degrees for a significant number of the Nation’s research scientists but that have not been major recipients of NIH support. The goals of the program are to (1) support meritorious research, (2) expose students to research, and (3) strengthen the research environment of the institution. Awards provide limited Direct Costs, plus applicable F&A costs, for periods not to exceed 36 months. This activity code uses multi-year funding authority; however, OER approval is NOT needed prior to an IC using this activity code. |
Effects of Cholinergic Axonal Plasticity On Spatial Orientation @ Northern Illinois University
Project Summary/Abstract Neurodegenerative disorders can produce significant impairments in a patient?s ability to maintain spatial orientation. The current changing age structure of the US population in combination with lack of effective treatments for neurodegenerative disorders presents serious challenges for society in the management of these patients. Evaluating novel therapies for neurodegenerative disorders will depend on identifying an appropriate animal model of spatial orientation. Rats, like humans, use environmental and self-movement cues to maintain spatial orientation. My research has focused on developing tasks for rats that dissociate the use of either source of information. The basal forebrain cholinergic projections undergoes significant degeneration during the progression of Dementia of the Alzheimer's Type. The experiments outlined in this proposal represent the next step in investigating the potential of enhancing neuroplasticity to improve cognitive deficits associated with pathology in the basal forebrain cholinergic neurons. One goal of the proposal examines whether anti-Nogo-A immunotherapy is sufficient to promote neuroplasticity basal forebrain cholinergic neurons in adult and senescent rats. Another goal is to evaluate the extent that enhanced neuroplasticity at either age is sufficient to ameliorate self-movement cue processing deficits. A final goal is to provide training experiences for undergrad and graduate students that will establish a foundation to pursue a career in the biomedical sciences. The results of these studies will advance our understanding of the effects of aging on spatial orientation and evaluate the potential of anti-Nogo-A immunotherapies as a novel intervention for neurodegenerative disorders.
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0.915 |