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High-probability grants
According to our matching algorithm, Michael Simon is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
1993 — 1999 |
Simon, Michael [⬀] |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Nsf Young Investigator
9357009 Simon Protein tyrosine kinases (PTKs) are important regulatory molecules that control many aspects of cellular growth, differentiation and metabolism. This work is directed toward understanding the mechanisms by which these proteins, particularly those which span the plasma membrane and are controlled by extracellular ligands, regulate intracellular events. The PI has focused his studies on the action of a particular transmembrane PTK that is encoded by the sevenless gene of Drosphilia melanogaster. Mutations that inactivate the sevenless protein (Sev) lead to a single known defect in the fly. Seven Enhancer of sevenless loci were identified. Mutations in four of the Enhancer of sevenless loci also affect signaling by other receptor PTKs. The PI has concentrated on the analysis of these four loci in hopes that they would encode components of a general PTK signaling pathway. One locus, Ras1, encodes a ras protein. ras proteins are known to be molecular switches that control many aspects of cellular activity. How Ras1 is activated has therefore become the crucial question which will be a major focus of this work. %%% This work explores a complex signal transduction system that functions in cellular and organizational development and growth control. Since the components of this system are highly conserved during evolution, it is likely that this knowledge gained will apply to all PTK signalling systems.
|
0.954 |
2004 — 2005 |
Simon, Michael S |
R21Activity Code Description: To encourage the development of new research activities in categorical program areas. (Support generally is restricted in level of support and in time.) |
A Culturally-Tailored Weight Loss Program
[unreadable] DESCRIPTION (provided by applicant): The adverse impact of obesity on insulin resistance and breast cancer prognosis is a matter of exceptional concern for African-American (AA) breast cancer survivors since a greater proportion of AAs than Caucasians are obese, insulin-resistant and diabetic. This proposal seeks to develop a culturally-tailored weight loss intervention for obese AA breast cancer survivors who have been free of recurrence. Weight loss requires a lifestyle change, and this cannot be done without consideration of the framework on which one's lifestyle is based. Weight loss counseling that incorporates spirituality may be especially relevant to AA women since they are more likely to rely on spiritual influences for support in their lives. All participants will receive 6 months of individualized dietary and exercise counseling combined with attendance at Weight Watcher's group meetings, an approach that we used to previously to effect a mean weight loss of 10% of initial body weight in 6 months. After learning basic weight loss behaviors, methods to integrate these new behaviors into each individual's lifestyle are needed to prevent regain and/or continue with loss to goal weight. Half the participants will be randomized to receive spirituality counseling for weight management from 6 to 18 months of intervention. This will be an attempt to strengthen spiritual beliefs which can then be used for dealing with areas important in long-term weight management: 1) coping in a crisis, 2) setting priorities, 3) dealing with emotional issues which trigger old behavior patterns and 4) developing accountability for following desired diet and exercise patterns. The non-denominational spirituality counseling will be individualized and based on each subjects' own relationship to a Higher Power. I will use an 8-component theoretical framework that we have modified from successful 12-step behavior change programs and faith-based weight loss programs used in the community. The tools used to achieve this will include meditation, readings, and the recording of thoughts. This feasibility study should allow us to develop the methods needed to interface spirituality counseling with more traditional weight loss approaches, and this can then be tested more fully in larger and longer-term studies. [unreadable] [unreadable] [unreadable]
|
0.904 |
2009 |
Simon, Michael |
N01Activity Code Description: Undocumented code - click on the grant title for more information. |
Women's Health Initiative
The purpose of the Women's Health Initiative (WHI) is to address cardiovascular disease, cancers of the breast and colon/rectum, and osteoporosis, the most common causes of death, disability, and impaired quality of life in postmenopausal women. The major components of the WHI are: a randomized controlled clinical trial of postmenopausal Hormone Therapy (HT), Dietary Modification (DM), and Calcium/Vitamin D supplementation (CaD);and a companion observational study (OS). The Clinical Trials and Observational Study components were completed in 2005;the WHI Extension Study continues to follow all consenting participants for health outcomes and selected exposures. The purpose of this additional follow-up is to describe the longer term effects of the original interventions, to document change in hormone use in participants from the HT trials, to expand the range of scientific questions that can be reliably addressed in the WHI, and to provide an infrastructure able to support additional investigations requiring some of the unique resources of a very large longitudinal study of postmenopausal women.
|
0.946 |