We are testing a new system for linking grants to scientists.
The funding information displayed below comes from the
NIH Research Portfolio Online Reporting Tools and the
NSF Award Database.
The grant data on this page is limited to grants awarded in the United States and is thus partial. It can nonetheless be used to understand how funding patterns influence mentorship networks and vice-versa, which has deep implications on how research is done.
You can help! If you notice any innacuracies, please
sign in and mark grants as correct or incorrect matches.
Sign in to see low-probability grants and correct any errors in linkage between grants and researchers.
High-probability grants
According to our matching algorithm, Joost X. Maier is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
2014 — 2016 |
Maier, Joost |
R03Activity Code Description: To provide research support specifically limited in time and amount for studies in categorical program areas. Small grants provide flexibility for initiating studies which are generally for preliminary short-term projects and are non-renewable. |
Systems-Level Interactions Underlying Valence Coding in Olfaction
DESCRIPTION (provided by applicant): Smell perception serves to provide information not only about odor quality (i.e., what the odor is), but also about the emotional meaning of the odor to an observer: besides being potentially musky or fruity, odors can be experienced as pleasant or aversive, dependent in part on past experience of the observer. Brain imaging research in human subjects has demonstrated that olfactory cortex-owing to its connectivity to neural systems involved in learning, memory and emotion-plays a central role in representing odor valence. However, the cellular processes underlying the transformation of odor quality coding to behaviorally-relevant odor valence coding is as of yet unknown. The present proposal combines electrophysiological recordings with behavioral measures of odor valence to probe responses of small ensembles of olfactory cortical neurons to a set of odors with a known range of valences. A first set of experiments is designed to test how and when valence-related neural firing patterns appear in olfactory cortex. Based on previous work from our lab investigating valence coding in the taste system, the specific hypothesis is that odor quality and valence are both encoded in the dynamic response patterns of single olfactory cortex neurons. The validity of the results obtained from these experiments will then be tested by changing the valence of an odor-pairing it with sweet taste, and observing whether the previously- identified valence-related response patterns change accordingly. Finally, the source of valence-related firing patterns will be determined by combining optogenetic inactivation of a range of candidate regions with electrophysiological recordings of odor responses in olfactory cortex. Guided by the extant literature as well as a wealth of preliminary data, inactivation of taste cortex, the amygdala and orbitofrontal cortex is hypothesized to affect valence-related firing patterns in olfactory cortex. The results obtained from these experiments will influence our understanding of emotion, memory, and a variety of clinical syndromes known to affect perception of valenced stimuli (most notably autism).
|
0.915 |