We are testing a new system for linking grants to scientists.
The funding information displayed below comes from the
NIH Research Portfolio Online Reporting Tools and the
NSF Award Database.
The grant data on this page is limited to grants awarded in the United States and is thus partial. It can nonetheless be used to understand how funding patterns influence mentorship networks and vice-versa, which has deep implications on how research is done.
You can help! If you notice any innacuracies, please
sign in and mark grants as correct or incorrect matches.
Sign in to see low-probability grants and correct any errors in linkage between grants and researchers.
High-probability grants
According to our matching algorithm, Christopher A. Knight is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
2002 |
Knight, Christopher A |
F31Activity Code Description: To provide predoctoral individuals with supervised research training in specified health and health-related areas leading toward the research degree (e.g., Ph.D.). |
Human Motor Unit Discharge Variability @ University of Massachusetts Amherst
DESCRIPTION: (provided by applicant) Neuromuscular disorders such as stroke or multiple sclerosis have consequences that affect the control of muscular force. Even though the origin of many disorders may be centrally determined, the fundamental unit of force control, the motor unit, will reflect the consequences. There is abundant information on control strategies such as the rules governing the recruitment of motor units. What we do not understand, however, is the nature and meaning of variability that exists within motor unit discharge behavior. The fluctuations in motor unit discharge during sustained muscular contractions have received very little attention compared to the study of variability in settings such as cardiovascular research. The mere appearance of random noise in a signal has often resulted in premature conclusions. However, it may be the case that conditions such as pathological tremor result from structure that exists within motor unit discharge fluctuations. Indeed, pilot data indicate that non-random structure is inherent in these fluctuations and I wish to further explore the characteristics and meaning of motor unit discharge variability. Motor unit discharge variability will be compared among muscles that are designed for precision control or gross force production. The effects of muscular force and sensory manipulations will be investigated in both muscle types. Each of these experimental conditions will be performed by older and young individuals to evaluate the impact of known age-related changes in motor unit morphology on motor unit discharge variability. The proposed research will systematically investigate analytical techniques that are new to motor unit research. The information content of such techniques will be compared to that provided by established analytical methods. Like the research on heart rate variability, I hope to provide effective diagnostic tools for evaluating neuromuscular health.
|
0.961 |
2007 — 2008 |
Knight, Christopher A |
R03Activity Code Description: To provide research support specifically limited in time and amount for studies in categorical program areas. Small grants provide flexibility for initiating studies which are generally for preliminary short-term projects and are non-renewable. |
Motor Unit Discharge and Slowed Motor Output in Elderly
[unreadable] DESCRIPTION (provided by applicant): The elderly are often frustrated by poor control during precision tasks, and slower production of muscular force has specific importance in fall prevention. Motor unit research is in dire need of expanded paradigms to provide new information about control mechanisms during real-world tasks. We will examine age-related differences in two relevant motor unit discharge behaviors and provide information that can be used to improve movement quality in older adults and also in patient populations. Aim 1 is about rate coding during the precise control of sinusoidal isometric contractions. It is hypothesized that that the amplitude of firing rate modulation is less in older adults, perhaps due to enhanced twitch summation of aged muscle fibers with slowed contractility. Aim 2 is about motor unit discharge behavior during rapid force production from rest as well as from a submaximal force level. It is hypothesized that during the initiation of rapid contractions, the initial firing rates of aged motor units will be slower and there will be fewer doublet discharges, as compared to young adults. Motor unit and muscular force recordings, surface electromyography and contractile properties will be obtained from the first dorsal interosseous muscle of 20 young (<30 years) and 20 older (>65 years) adults. Successful experiments in these conditions can be considered significant progress in motor unit research. In addition to furthering knowledge of normal aging at the level of the motor unit, this project will provide vast new information about motor unit discharge behavior in general. Consider for example: 1) the value of this normative data for similar research in patient populations, and 2) a better knowledge of neural commands in healthy individuals can help to improve the functional electrical stimulation of paralyzed muscle. This project also provides the basis for future research on the adaptability of these neural factors and function in older adults and patient populations. [unreadable] [unreadable]
|
1 |