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High-probability grants
According to our matching algorithm, Hiroshi Asanuma is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
1974 — 1977 |
Asanuma, Hiroshi |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Central Mechanisms of Motor Control |
1 |
1985 — 1994 |
Asanuma, Hiroshi |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Cerebral Cortical Control of Movement
The purpose of the proposed study is to increase our understanding of how the motor cortex controls movement and subsequently to contribute toward the better treatment of human motor dysfunctions. During the past grant years, we have shown that the motor cortex receives peripheral inputs directly from the thalamus and not through the sensory cortex. We have already shown there are cortical efferent zones within the motor cortex which control contraction of individual muscles, hence the motor cortex and the periphery are connected by the simplest loop circuit. During the coming years, we plan to elucidate the functional significance of various inputs converging into the motor cortex. This will be done by delivering microstimulation to various parts of the central nervous system and examining the effects using the cortico-peripheral loop circuit. The study will hopefully explore further insights of the motor cortex and yield knowledge which will be applicable to the treatment of the patients.
|
1 |
1986 — 1987 |
Asanuma, Hiroshi |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Cerebal Cortical Control of Movement
The ultimate purpose of the proposed study is to increase our understanding of how the motor cortex controls movements and subsequently to contribute toward the better treatment of human motor dysfunctions. The specific aim during the coming years is to elucidate the neuronal mechanisms of how peripheral sensory input contribute to the smooth execution of voluntary movements. It has been shown that there are closed loop circuits between the motor cortex and the periphery and each loop is specific for a particular muscle. It has recently been shown that these circuits play an important role during voluntary movements. As for the neuronal mechanisms of these circuits, we have proposed that each loop circulates impulses before and during the movements to increase the excitability of neurons related to each loop, i.e., preferential bias theory. This hypothesis will be examined through chronic and acute experiments. Chronic experiments will be carried out using cynomolgus monkeys. They will be trained to pick up food pellet from rotating food board. Then a closed chamber will be installed over the motor cortex and activity of motor cortical neurons will be studied before and during the pick-up movements. Distribution of preferentially biased neurons in relation to location of regular movement related neurons will be examined. Effect of interruption of the loop circuits to these preferential bias will also be examined. Acute experiments will be carried out using cats. It has been shown that peripherally evoked activity of motor cortical neurons is modified by the input from the sensory cortex. The mode of modification will be studied by delivering conditioning and testing stimuli to the sensory cortex and the thalamus. The effect of conditioning stimuli will be examined using monosynaptic PSPs elicited by the test stimuli as indicators. Various combinations of conditioning and test stimuli will be used.
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1 |