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High-probability grants
According to our matching algorithm, Peter A. Goldstein is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
1997 — 1999 |
Goldstein, Peter A |
K08Activity Code Description: To provide the opportunity for promising medical scientists with demonstrated aptitude to develop into independent investigators, or for faculty members to pursue research aspects of categorical areas applicable to the awarding unit, and aid in filling the academic faculty gap in these shortage areas within health profession's institutions of the country. |
Serotonergic Control of Spinal Cord Neurotransmission @ Columbia University Health Sciences
The long-term objective of this grant is to further understand the cellular mechanisms underlying the pathophysiology of both acute and chronic pain states. The neurophysiological mechanisms underlying the transmission and processing of nociceptive, or painful, stimuli within the central nervous system remain poorly understood. Multiple neurotransmitter system are thought to be involved in the transmission of pain signals, including but not limited to those mediated by glutamate and serotonin (5- HT). Although substantial evidence exists implicating glutamate as the principle neurotransmitter responsible for excitatory transmission, the direct and.or regulatory effects of the 5-HT system on the glutamatergic system are well defined. The overall purpose of this project is to help further define the interactions between the glutamatergic and 5-HT transmitter systems in the spinal chord so as to obtain a clearer understanding of the processes that regulate nociceptive afferent neurotransmission. To investigate how glutamatergic neurotransmission is regulated by 5-HT, an in vitro preparation will be used. Pre-synaptic stimulation is achieved by stimulating the dorsal root and post-synaptic whole-cell recordings are made from visually identified single neurons in the substantia gelatinosa using the patch clamp technique. Briefly, a thin transverse section of spinal cord with dorsal roots attached is obtained from post-natal rat pup. The spinal cord slice is then superfused in an extracellular bath solution containing selective agonists and antagonists for specific 5-HT receptor subtypes while recording dorsal root-evoked post-synaptic events. Proceeding in this manner will enable us to identify which 5-HT receptor subtypes modulate glutamatergic transmission. Once the receptor subtypes are identified, the site(s) of action, pre-and/or post-synaptic, will be identified. The results will hopefully provide new insights into the mechanisms of pain transmission as well as suggest novel methods for providing analgesia in both the acute and chronic setting.
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0.907 |
2004 — 2008 |
Goldstein, Peter A |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Anesthetic Effects On Thalamic Synaptic Transmission @ Weill Medical College of Cornell Univ
DESCRIPTION (provided by applicant): The mechanisms by which a diverse group of pharmacological agents produce anesthesia remain uncertain. A potentially important region within the central nervous system (CNS) for contributing to the anesthetized state is the thalamus; it is a critical relay site for sensory information, and two specific nuclei, the ventrobasal nucleus and the reticular nucleus, are considered to be essential structures in the generation of consciousness and sleep. Since anesthetics depress consciousness and induce "sleep," it is important to understand how anesthetics alter synaptic transmission and cell physiology in these two regions. Inhibitory synaptic transmission helps regulate thalamic function, and the GABA-A receptor is the primary receptor for mediating fast inhibitory synaptic transmission within the CNS. The focus of this proposal is to explore how two different anesthetic agents, the volatile anesthetic - isoflurane, and the intravenous anesthetic - propofol, modulate inhibitory synaptic transmission and neuronal activity in the ventrobasal nucleus and reticular nucleus. Aim 1 - What are the effects of propofol on synaptic transmission and membrane excitability in the thalamus? The hypothesis to be tested is that propofol will potentiate synaptic inhibition and depress neuronal activity to a greater extent in VB neurons than in RTN neurons. Aim 2 - What are the effects of isoflurane on synaptic transmission and membrane excitability in the thalamus? The hypothesis to be tested is that isoflurane will potentiate synaptic inhibition and depress neuronal activity to a greater extent in VB neurons than in RTN neurons. Aim 3 - How do propofol and isoflurane affect the ability of the RTN to regulate action potential firing in the VB? The hypothesis to be tested is that both agents will facilitate RTN-induced inhibition of action potential firing in VB neurons. By better understanding how anesthetic agents interact with specific subunits of the GABA-A receptor in different regions of the brain, it may be possible to design more selective, and therefore safer, anesthetics.
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