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High-probability grants
According to our matching algorithm, Peter Dews is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
1987 — 1989 |
Dews, Peter B |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Modulation of a Behavioral Effect of Cocaine @ Harvard University (Medical School)
The behavioral effects of cocaine are crucial to its liability to be abused. All its behavioral effects merit study. CD1 mice have been trained to run in one direction around a circular runaway, receiving milk at every third circuit. Under increasing doses of cocaine the amount of running in the direction opposite to training increases until it actually exceeds the amount in the reinforced direction, but only in some mice. Others show either no, or only slight, tendency to run in the unreinforced direction at any dose of cocaine. Mice that reverse under cocaine tend to have somewhat more running in the unreinforced direction even under control conditions. The "reversing" phenomenon will be investigated to determine its relation to running under control conditions and the relative amounts of running in the 2 directions will be deliberately manipulated in mice, to see whether such training affects the response to cocaine. Methamphetamine, chlordiazepoxide, pentobarbital and chlorpromazine over full dosage range will be studied to put the cocaine effect into perspective. Finally, other strains of mice will be studied to see how general the "reversing" phenomena is among other strains of mice.
|
0.958 |
1989 — 1997 |
Dews, Peter B |
P51Activity Code Description: To support centers which include a multidisciplinary and multi-categorical core research program using primate animals and to maintain a large and varied primate colony which is available to affiliated, collaborative, and visiting investigators for basic and applied biomedical research and training. R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Neurobehavioral Effects of Simian Aids @ Harvard University (Medical School)
Encephalopathy, with psychiatric and neurological signs and symptoms, is common in HIV infections in humans. A Simian Immunosupressive Virus (SIV) in rhesus monkeys also produces encephalopathy as well as immunosuppression. SIV in monkeys could therefore provide a valuable system for mechanistic and therapeutic studies of the CNS effects of a lentivirus, closely similar to HIV, in a primate related to man in which sophisticated behavioral assessments can be made. Monkeys will be trained in a number of tasks homologous to the functions that are impaired in HIV infections of the CNS in humans. When a steady state baseline has been obtained, the monkeys will be inoculated with SIV and the behavioral assessments continued until death of the subject. Detailed neuropathology will then be conducted. When the natural history of the progression has been adequately characterized subjects will be killed at different stages of the disease so that the progressive behavioral deficits can be related to the progressive neuropathological changes early in the disease and without the complication of terminal infections. The behavioral assessments will include: responding under FI schedules; a Delayed matching-to-sample procedure; a Strength test requiring sustained strong isometric work; a Steadiness test requiring a subject to hold a rod away from the edges of a hole; and a Visual scanning task that requires a subject to recognize a "g" or and "I" in large matrices of letters that include "q"s and "l"s.
|
0.958 |