| 1985 — 1989 |
Morse, William H. |
R01Activity Code Description:
To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Analysis of Behavior Controlled by Drug Injections @ Harvard University (Medical School)
The objective of the proposed research is to study pharmacological and behavioral determinants of drug dependence by systematically investigating the control of behavior by scheduled injections of drugs under diverse conditions. The emphasis of this proposal is to analyze how such behavior is influenced by historical factors, especially previous experience with drugs, by suppression of behavior as a result of noxious consequences, and by associated stimulus conditions in the environment. Studies of historical determinants of drug self-administration will evaluate how chronic administration of opiates and barbiturates alters the subsequent control of behavior by these and other classes of drugs (e.g., psychomotor stimulants). Performances developed and maintained under different schedules of drug injection will be compared directly with performances maintained under formally identical conditions by other consequences of behavior, such as presentation of food or electric shock. Studies of the suppression (punishment) of behavior will investigate conditions under which drug self-administration can be attenuated by scheduling noxious stimuli as additional consequences of responding. The suppressant effects of drugs, such as histamine and chlorpromazine, and of other noxious consequences, such as electric shock, on behavior maintained by scheduled injections of drugs and other events will be determined. The effects on suppressed behavior of pretreatment with selected drugs also will be evaluated. Studies of the conrol of behavior by invironmental stimuli associated with self-administered drugs will assess the contribution of such stimuli to the maintenance of persistent drug taking. Optimal and limiting conditions for controlling sequences of behavior by associated stimuli will be investigated under second-order schedules of drug injection. Overall, the proposed research will provide basic information on behavioral and pharmacological factors involved in both the maintenance and suppression of behavior by consequent injection of drugs.
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| 1985 |
Morse, William H. |
R01Activity Code Description:
To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Drug Action On Behavior Controlled by Noxious Stimuli @ Harvard University (Medical School)
This research proposal is to study the effects of opioids and opioid antagonists, and of prototypical and atypical antipsychotic drugs on behavior controlled by noxious stimuli and other consequent events. One major objective will be to specify the pharmacological and environmental factors responsible for the development and expression of supersensitivity to the behavioral effects of opioid antagonists. Studies will be conducted on how the development of supersensitivity is modified by the type of schedule and type of consequent event that maintains behavior, and on how developed supersensitivity alters the behavioral effects of opioids from different chemical classes. Other studies will investigate how the behavioral effects of opioid antagonists are modified by pretreatment with other drugs in supersensitive and normal subjects, and on how supersensitivity alters the antagonistic effects of opioid antagonists. Supersensitivity also will be studied in relation to the suppression of behavior by response-produced injections of opioid antagonists or by stimuli associated with injections of antagonists. A second major objective of the proposed research is to characterize the distinctive behavioral effects of prototypical and atypical antipsychotic drugs and to specify how these effects are determined by the environmental conditions that maintain or suppress behavior.
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| 1985 — 1987 |
Morse, William H. |
T32Activity Code Description:
To enable institutions to make National Research Service Awards to individuals selected by them for predoctoral and postdoctoral research training in specified shortage areas. |
Research Training - Biological Sciences @ Harvard University (Medical School) |
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| 1987 — 1996 |
Morse, William H. |
R37Activity Code Description:
To provide long-term grant support to investigators whose research competence and productivity are distinctly superior and who are highly likely to continue to perform in an outstanding manner. Investigators may not apply for a MERIT award. Program staff and/or members of the cognizant National Advisory Council/Board will identify candidates for the MERIT award during the course of review of competing research grant applications prepared and submitted in accordance with regular PHS requirements. |
Drug Action On Behavior and Physiological Function @ Harvard University (Medical School)
This research proposal is to study the effects of opioids and opioid antagonists, and of prototypical and atypical antipsychotic drugs on behavior controlled by noxious stimuli and other consequent events. One major objective will be to specify the pharmacological and environmental factors responsible for the development and expression of supersensitivity to the behavioral effects of opioid antagonists. Studies will be conducted on how the development of supersensitivity is modified by the type of schedule and type of consequent event that maintains behavior, and on how developed supersensitivity alters the behavioral effects of opioids from different chemical classes. Other studies will investigate how the behavioral effects of opioid antagonists are modified by pretreatment with other drugs in supersensitive and normal subjects, and on how supersensitivity alters the antagonistic effects of opioid antagonists. Supersensitivity also will be studied in relation to the suppression of behavior by response-produced injections of opioid antagonists or by stimuli associated with injections of antagonists. A second major objective of the proposed research is to characterize the distinctive behavioral effects of prototypical and atypical antipsychotic drugs and to specify how these effects are determined by the environmental conditions that maintain or suppress behavior.
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| 1988 — 1992 |
Morse, William H. |
T32Activity Code Description:
To enable institutions to make National Research Service Awards to individuals selected by them for predoctoral and postdoctoral research training in specified shortage areas. |
Research Training--Biological Sciences @ Harvard University (Medical School) |
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| 1992 — 1997 |
Morse, William H |
P51Activity Code Description:
To support centers which include a multidisciplinary and multi-categorical core research program using primate animals and to maintain a large and varied primate colony which is available to affiliated, collaborative, and visiting investigators for basic and applied biomedical research and training. R37Activity Code Description:
To provide long-term grant support to investigators whose research competence and productivity are distinctly superior and who are highly likely to continue to perform in an outstanding manner. Investigators may not apply for a MERIT award. Program staff and/or members of the cognizant National Advisory Council/Board will identify candidates for the MERIT award during the course of review of competing research grant applications prepared and submitted in accordance with regular PHS requirements. |
Drug Action On Behavior &Physiological Function @ Harvard University (Medical School)
substance abuse related disorder; respiratory system; psychology; drug screening /evaluation; Primates; Mammalia; biological products; nervous system; behavioral /social science research tag;
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