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High-probability grants
According to our matching algorithm, Gary P. Dohanich is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
1987 — 1989 |
Dohanich, Gary P |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Cholinergic Regulation of Sexual Behavior @ Tulane University of Louisiana |
1 |
1991 — 1996 |
Dohanich, Gary |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Cholinergic Regulation of Behavior
Steroid hormones exert dynamic control over a wide variety of biological functions in mammals. An important goal is to gain an understanding of the mechanisms by which steroids, (e.g. estrogens, androgens, progestins) interact with the nervous system to alter physiological and behavioral functions. It is known that steroids can affect behavior by altering chemical communication between brain cells. Indeed Dr. Dohanich reports that estrogen influences the chemical signals produced by acetylcholine, a major muscarinic cholinergic neurotransmitter. He has shown that estrogen activates specific behaviors in females, in part, through the modulation of acetylcholine neurotransmission. Dr. Dohanich plans to extend his initial findings by determining the effects of cholinergic manipulations on a variety of steroid hormone regulated behaviors. In addition, he will investigate the role that various muscarinic receptors subtypes play in the regulation of these behaviors. Finally, Dr. Dohanich will determine the changes in cellular receptors for acetylcholine following hormonal manipulations that alter these specific behaviors. The results of this work will enhance our understanding of the role of neurotransmission in the regulation of mammalian behavior. This is important since the interplay between neurotransmitters and steroid hormones is a fundamental mechanisms that influences many functions in the central nervous system of mammals including humans. Consequently, this research has important implications for understanding the biological processes that underline steroid- dependent events ranging from reproduction to human mood states.
|
0.915 |
1996 — 2002 |
Dohanich, Gary |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Estrogen Regulation of Learning and Memory
9514816 Dohanich The neural basis for the development of learning and memory is currently unclear. However, studies have implicated the cholinergic nerve network in the brain as being an integral chemical component of the process of learning and memory. Recent investigations noted that gonadal hormones, particularly estrogen, may participate in these complex behaviors, especially during advancing age. The investigations of Dr. Dohanich will establish the linkage between these chemical messenger molecules in learning and memory across the ages. As part of these investigations, the experiments will characterize the hormonal conditions that affect performance in tasks of learning and memory, particularly following the compromise of the cholinergic system. Further innovative investigations will elucidate the interrelationship of the environment, either simple or complex, with the hormonal milieu in the development of learning and memory. Unfortunately, ample basic information regarding the complex interactions of the brain chemical messenger molecules and the environment has precluded a clear understanding of the development of learning and memory behaviors. The present investigations will foster greater understanding of these critical behaviors. Moreover, the role of the environment in learning has been proposed but critical investigations have not been undertaken. These studies will be among the first to generate quantifiable data on the role of the environment in information processing in biological systems.
|
0.915 |