Ellis Meng - US grants
Affiliations: | Biomedical Engineering | University of Southern California, Los Angeles, CA, United States |
Area:
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The funding information displayed below comes from the NIH Research Portfolio Online Reporting Tools and the NSF Award Database.The grant data on this page is limited to grants awarded in the United States and is thus partial. It can nonetheless be used to understand how funding patterns influence mentorship networks and vice-versa, which has deep implications on how research is done.
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High-probability grants
According to our matching algorithm, Ellis Meng is the likely recipient of the following grants.Years | Recipients | Code | Title / Keywords | Matching score |
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2006 — 2012 | Meng, Ellis | N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
@ University of Southern California Abstract |
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2007 — 2008 | Meng, Ellis | R21Activity Code Description: To encourage the development of new research activities in categorical program areas. (Support generally is restricted in level of support and in time.) |
Implantable Mems Drug Delivery Device For Glaucoma Management @ University of Southern California [unreadable] DESCRIPTION (provided by applicant): Glaucoma is a chronic disease characterized by progressive optic nerve damage and vision loss. There is no cure for glaucoma; management of the disease focuses on lowering intraocular pressure which has been effective in reducing the progression of the disease. One therapeutic treatment involves the administration of timolol to reduce the production of aqueous humor by the ciliary epithelium. Unfortunately, the targeted structures are located in remote inner regions of the eye. The traditional mode of topical drug delivery is limited in efficacy by physiological barriers, side effects, and poor patient compliance with the drug regimen. Side effects include but are not limited to severe cardiac effects with beta blocker drops. This proposal investigates a novel method for targeted intraocular delivery of glaucoma medication at therapeutic levels with a microelectromechanical systems (MEMS)-fabricated microfluidic device. This device is implanted in the subconjunctival space and consists of a refillable drug reservoir, electrolysis- actuated pump, transscleral cannula, and flow control valves. The medication contained within the reservoir is driven by the electronically-controlled pump through the flexible transscleral cannula which is directed into the anterior chamber and thereby to the ciliary epithelium - the site of treatment. Directed delivery to intraocular tissues reduces the diffusion distance of the drug, increases the efficacy of each dose, reduces the size of the dose, and reduces the amount of unintended systemic absorption of unused drug and the associated side effects. Furthermore, this platform enables precise temporal and spatial control of ocular drug delivery not possible with conventional methods. Specific Aim 1: Fabrication of a multi-component MEMS drug delivery system for targeted delivery of glaucoma medication. A fully integrated device consisting of an electrolysis pump, drug reservoir, check valve, and cannula will demonstrate controlled and repeatable dosing. Specific Aim 2: Demonstration of implantation and device refillability in ex vivo experiments. Enucleated porcine eyes will be used to develop surgical procedures and device refill techniques. Specific Aim 3: Demonstration of controllable and repeatable delivery of timolol in a rabbit model of glaucoma. The long term biocompatibility and function of devices will be demonstrated and then the device will be implemented in an animal model of glaucoma. Efficacy of the device in managing intraocular pressure will be compared to topically applied timolol. For the effective management of glaucoma, a novel miniaturized drug delivery device will deliver drugs directly into the interior of the eye. This method of delivery will maximize the therapeutic benefits of the drug therapy while minimizing risk to the patient by reducing side effects. The broad drug compatibility and flexibility in implementing the device allow its application to the treatment of other chronic diseases, in particular, diseases associated with vision loss requiring treatment of tissues located in remote inner regions of the eye. [unreadable] [unreadable] [unreadable] [unreadable] |
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2011 — 2013 | Meng, Ellis | N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
@ University of Southern California The pump proposed in this I-Corps effort addresses critical unmet needs by providing a miniaturized mouse-compatible form factor, wireless power and remote control features, and fully-customizable dosing capability for chronic drug administration studies. The team addresses the immediate need from academia and industry for pumps in both laboratory animal research for scientific discovery and preclinical drug studies. Applying the pump technology at the earliest stage of preclinical validation may improve the development of new drugs and enable new treatment paradigms. The scalability of the technology also has the potential to extends the addressable market beyond laboratory animal research to human patient care, The long-term goal is to leverage this technology in combination with novel therapeutics that cannot be delivered by other means to provide patient-specific dosing profiles in humans in a manner that maximizes therapeutic benefit while minimizing side effects. This I-Corps effort will result in a plan to transition the proposed innovation to the marketplace, fabrication of prototypes, and technology demonstration. |
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2012 — 2016 | Meng, Ellis | N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
@ University of Southern California PI: Meng, Ellis |
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2012 — 2014 | Meng, Ellis | R21Activity Code Description: To encourage the development of new research activities in categorical program areas. (Support generally is restricted in level of support and in time.) |
Wirelessly-Operated Implantable Mems Micropumps For Drug Infusion in Mice @ University of Southern California DESCRIPTION (provided by applicant): Mice, especially transgenic and knockout models of human diseases, have been used in laboratory research and preclinical studies and have had profound impact on many fields, including neuroscience, medicine, and pharmacology. However, few practical tools exist for chronic drug administration in mice. Traditional methods most frequently utilize the oral, intravenous, and intraperitoneal routes that involve restraining and intensive handling of animals. Manual handling of animals provides only intermittent dosing and is known to induce stress and other significant physiological impacts that may alter experimental outcomes. Continuous dosing is possible with external infusion pumps or implantable osmotic pumps. External pumps require catheter tethers that limit natural movement and reshapes normal behavior. Osmotic pumps have a fixed drug payload and cannot be refilled which limits their use in chronic studies. No implantable pump is currently available that is wirelessly-operated and can achieve any desired drug release profile. The combination of these capabilities will provide a new tool for precise drug administration in chronic studies in mice and other smaller animals without the need for handling. To achieve this goal, we propose a wirelessly-operated and refillable implantable infusion pump that is suitable for chronic drug administration in mice. This pump platform is based on our prior experience developing implantable pumps for larger animals such as rats and rabbits. Here, we will address the engineering challenges to enable a tenfold reduction in scale required to realize a mouse pump. This is enabled by using microfabrication techniques to reduce the size of pump components without compromising their electrical or mechanical performance (Specific Aim 1). Pumps will be assembled and integrated with wireless telemetry and a software graphical user interface that enables user-initiated remote activation of the pump anywhere within a standard mouse cage (Specific Aim 2). We will demonstrate precise control of drug administration such that any desired drug release profile can be achieved by using WIIP to deliver compounds into simulated biological materials (Specific Aim 3). WIIP will enable unprecedented control of drug profiles in vivo in long term experiments in a hands-free, needle-free, and tether-free manner. In doing so, WIIP will enable studies in more naturalistic environments, more reliable assessment of drug responses without stress-related artifacts, and allow around-the-clock drug delivery with artificial animal/human interactions. WIIP provides a transformative new tool for both laboratory research and preclinical studies that is applicable to a broad range of biomedical applications. |
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2013 — 2014 | Meng, Ellis | N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
2013 Microtechnologies in Medicine and Biology Conference, April 10-12, 2013, Marina Del Ray, Ca @ University of Southern California 1314901 |
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2013 — 2016 | Meng, Ellis | N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
@ University of Southern California This PFI: AIR Technology Translation project focuses on translating the first wireless, fully programmable, implantable micro infusion pump with integrated dose tracking for closed-loop control to fill the current technology gap in drug administration technology for small animals research. The translated technology has the following unique features: sensors for electronic real time confirmation of actual delivery and dosed volumes, wireless operation capable of accessing a wide dynamic range of flow rates, and form factor suitable for use in mice that provides exemplary performance, efficiency, and efficacy, when compared to the leading competing infusion technologies, whether implantable or not, in this market space. The project accomplishes this goal by integrating wireless circuitry for controlling infusion and tracking doses into a tiny form factor suitable for use in a miniaturized infusion pump resulting in a working prototype closed-loop implantable infusion system that will be demonstrated at the benchtop. The partnership engages Stevens Center for Innovation, Viterbi Student Institute for Innovation, Lloyd Greif Center for Entrepreneurial Studies, and industry partners (Fluid Synchrony, SAI Infusion Technologies, and Charles River) to provide guidance in the drug delivery technology space and other aspects of commercialization, manufacturing, and financing as they pertain to the potential to translate the technology along a path that may result in a competitive commercial reality. The potential economic impact is expected to be improved scientific discovery and drug development in the next decade, which will contribute to the U.S. competitiveness in the drug delivery technologies space. The societal impact, long term, will be new therapies, greater drug efficacy, reduced side effects, improved treatment outcomes, and quality of life, especially as they relate to the potential impact of this effort on the long term goal of realizing closed-loop clinical infusion systems. |
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2013 — 2017 | Meng, Ellis Gupta, Malancha (co-PI) [⬀] Weiland, James (co-PI) [⬀] |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Efri-Bioflex: Hybrid Polymer-Paper Based Multi-Sensor Implants For Continuous Remote Monitoring @ University of Southern California Hydrocephalus is a chronic incurable condition that characterized by the excess accumulation of cerebrospinal fluid in the brain and affects 1 to 2 in every 1000 births per year. Today, hydrocephalus is primarily treated using an implanted shunt to drain excess fluid, a technique that is virtually unchanged since its introduction in the 1950?s. Its temporary efficacy has made hydrocephalus one of the most frequently encountered problems in neurosurgery with repeated shunt revisions or replacements required over the lifetime of a patient. A major unmet need is early diagnosis of shunt malfunction which is difficult, unreliable, and costly. |
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2016 — 2018 | Meng, Ellis | U01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Flexible Neural Probe Arrays For Large-Scale Cortical and Subcortical Recording @ University of Southern California Implantable neural electrodes have enjoyed decades of development but the ability to record resolvable neuronal activities is often reduced or completely lost over time. This is true regardless of species with recording lifetimes of months to at best a few years in animal; although select neural probes have been successfully implemented in human, the recording lifetimes are short (<5 years). Overcoming the limitations of today?s implant technologies could revolutionize the design of future neural prosthetic platforms, which in turn, would have a profound impact on the medical treatment of multiple neurological disorders using brain-machine interfaces. The goal of this proposal is to achieve large scale recordings over long periods of time. To achieve a stable, long-term neuronal interface, we will use a multi-pronged approach involving innovation in polymer micromachining and integration and packaging and the application of principles of solid mechanics and beam theory. Multi-level polymer micromachining will enable high electrode density on both sides of single shanks with minimal area dedicated to wiring. Multiple shanks will be connected by a backplane consisting of a ribbon cable into which electrical connectivity has been established with an embedded application specific integrated circuit (ASIC) chip. The chip contains circuits that provide signal amplification and multiplexing; the latter will greatly reduce the number of external wire connections and thus the footprint required for the overall implant. By leveraging the increase in stiffness of a shank as length decreases and biodegradable polymers, deep implantation of bare probes and probe arrays will be realized without the use of existing stiffener approaches that increase the cross sectional diameter by orders of magnitude. The collaborative team consists of biomedical engineer with specific expertise in microfabrication of implantable systems, a circuit expert, and a biomedical engineer with expertise in neural engineering of hippocampal prostheses. Together, we will develop the probe array technology and achieve integration of microelectronic circuits. In addition, the new probe array system will be demonstrated in rat to collect electrophysiological recordings in the hippocampus and compared to the performance of gold standard microwire array implants. These studies will be complemented by histological analysis. |
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2016 — 2018 | Meng, Ellis | N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Pfi:Air - Tt: Wireless Implantable Pressure Sensor For Continuous Monitoring of Chronic Disorders @ University of Southern California This PFI: AIR Technology Translation project focuses on translating the first wireless, microfabricated, microbubble-based pressure sensor for physiological monitoring to fill the current technology gap in chronic, implantable diagnostic sensors. The translated technology offers reliable pressure recordings in real-time for patients suffering from chronic, often life-long medical conditions for which elevated pressure is a risk factor or indicator, and removes the need for bulky exterior diagnostic tools. The microbubble pressure sensor has the following unique features: biocompatible construction, small footprint (less than 0.1 sq. mm.), wireless control and power, and a microbubble transduction mechanism. The microbubble transduction mechanism circumvents failures modes such as mechanical fatigue and biofouling, which plague sensors that rely on deflection in elastic membranes. These features provide for an unobtrusive, reliable implant, with greater application to chronic in vivo monitoring compared to current state-of-the-art in physiological pressure monitoring. The project will result in a working prototype pressure sensor and critical data to de-risk on-going development. |
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2017 | Meng, Ellis | N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Pfi:Air - Tt: Wireless Implantable Pressure Sensor For Continuous Monitoring of Chronic Disorders @ University of Southern California This PFI: AIR Technology Translation project focuses on translating the first wireless, microfabricated, microbubble-based pressure sensor for physiological monitoring to fill the current technology gap in chronic, implantable diagnostic sensors. The translated technology offers reliable pressure recordings in real-time for patients suffering from chronic, often life-long medical conditions for which elevated pressure is a risk factor or indicator, and removes the need for bulky exterior diagnostic tools. The microbubble pressure sensor has the following unique features: biocompatible construction, small footprint (less than 0.1 sq. mm.), wireless control and power, and a microbubble transduction mechanism. The microbubble transduction mechanism circumvents failures modes such as mechanical fatigue and biofouling, which plague sensors that rely on deflection in elastic membranes. These features provide for an unobtrusive, reliable implant, with greater application to chronic in vivo monitoring compared to current state-of-the-art in physiological pressure monitoring. The project will result in a working prototype pressure sensor and critical data to de-risk on-going development. |
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2018 — 2020 | Meng, Ellis | N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Pfi-Tt: Sensor System For Early Warning of Hydrocephalus Shunt Failure @ University of Southern California The broader impact/commercial potential of this PFI project is to improve treatment of hydrocephalus. Since the 1950s, the gold standard of care has been to implant a tube, called a shunt, that drains excess fluid surrounding the brain elsewhere in the body where it can be safely absorbed. While this treatment is effective, the shunts fail at high rates and most commonly because of clogging. Because there are no clear patient symptoms and medical imaging technologies do not have sufficient resolution, patients live in fear that their headache may be an early sign of failure and must live close to a major medical center. A major reason why shunt technology has not advanced in many decades is that there are no sensors that can determine when and why shunts fail. In the near term, this innovation in miniaturized sensing technology will enable definitive diagnosis of shunt failure and in the long term, provide valuable data that can inform the design of failure-resistant shunts. The potential societal impacts are reduced emergency room visits and improved quality of life for patients and family members. The potential commercial impacts are new products for hydrocephalus and other medical conditions. |
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2018 — 2019 | Meng, Ellis Reiss, Lina Fischer-Baum, Simon (co-PI) [⬀] Raphael, Robert [⬀] Sweeney, Alex |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Planning Grant: Engineering Research Center For Auditory Bioengineering @ William Marsh Rice University The Planning Grants for Engineering Research Centers competition was run as a pilot solicitation within the ERC program. Planning grants are not required as part of the full ERC competition, but intended to build capacity among teams to plan for convergent, center-scale engineering research. |
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2020 — 2021 | Meng, Ellis Song, Dong (co-PI) [⬀] |
U24Activity Code Description: To support research projects contributing to improvement of the capability of resources to serve biomedical research. |
A Technology Resource For Polymer Microelectrode Arrays @ University of Southern California The purpose of this proposal is to disseminate polymer microelectrode arrays and promote their integrated into neuroscience research practice. Such polymer neural interfaces are mechanically compliant to promote stability of the device-tissue interface and versatile in that both surface and penetrating electrode arrays can be produced with the same technology. To accomplish their dissemination and integration, a resource will be created that offers the ability to customize electrode designs for their applications that are compatible with other recording and stimulation technologies and imaging technologies. The state-of-the-art polymer probes with high channel count will be made available to select users through project proposals selected with the input of a steering committee and to the broader community as prototypes on shared multi-project processing runs. Importantly, devices produced through user engagement will be functionally tested and ready to implant. The multi-project wafer processing runs will allow for small numbers of custom devices from multiple users to be produced on a single mask set which will allow users to debug and perform design adjustments and allow the resource to efficiently utilize wafer real estate. The resource also offers a testing service to validate electrode arrays made by external users. The successful in vivo implementation of interface technologies is dependent of their repeatable construction and reliable performance; these may be difficult to attain in small batch prototypes and even in commercially produced devices because of lack of testing capabilities or expertise. Device testing services will ensure rigor, reproducibility, and transparency for the benefit of the user community. The testing approach will be comprehensive, beginning at the materials level and progressing to the interface, interconnections, and packaging. Testing will include techniques that examine surface properties, material properties, mechanical performance, electrical and electrochemical performance, and lifetime testing. As needed, testing will be tailored for each project as dictated by its end use requirements. The testing methodologies will be rigorously documented and also disseminated. To facilitate adoption of technologies by users, the resource will offer onsite training on how to implement electrode arrays in vivo in rat. The resource seeks to enable BRAIN Initiative investigators and the broader community to achieve large scale recordings that will impact fundamental neuroscience research and next generation neuroprosthetic platforms for the treatment of multiple neurological disorders and conditions. |
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2020 — 2021 | Meng, Ellis | R21Activity Code Description: To encourage the development of new research activities in categorical program areas. (Support generally is restricted in level of support and in time.) |
Flexible Bioelectronic Sensors For Non-Contact Detection of Obstruction in Pediatric Vascular Shunts @ University of Southern California Neonatal patients having one or two ventricle defects are dependent on the modified Blalock-Taussig shunt (mBTS) to establish proper systemic blood flow. While the procedure has saved many newborns with cyanotic heart defects, the obstruction of mBTS due to either thrombus and/or intimal build up has been problematic leading to high mortality and morbidity. In addition, the cost of care is among the most expensive for any surgical procedure. Shunt obstruction can lead to hypoxia and sudden death due to insufficient pulmonary circulation. Shunt occlusion can be sudden and without enough warning to prevent rapid deterioration of the patient?s condition. Alternatively, shunt obstruction can also occur gradually. But even in this case, the narrowing of the shunt lumen may result in similar adverse side effects. When emergency intervention is required, despite very aggressive resuscitation, it is frequently difficult to save infants with shunt obstruction. Recanalization can correct shunt obstruction. Imaging methods are inadequate to resolve obstruction within these 3-5 mm diameter shunts. Therefore, early detection of shunt obstruction is critical to avoid the need for emergency intervention and preventable loss of life. This proposal addresses the unmet clinical need for miniature sensors that can detect significant changes in blood flow through mBTS necessitating intervention. Developing flow sensors suitable for use with shunts poses several unique challenges but if successful, can reduce morbidity and mortality through timely, informed recanalization. The systematic approach involves first demonstrating proof-of-concept at the benchtop of non-contact flow sensing, followed by developing shunt sensor systems suitable for in vivo use, and then a final demonstration of wired sensors in a pig model. The expected outcome of this work is the demonstration of a non-contact flow sensor suitable for use with shunts to enable a sensor-shunt system as mBTS. The successful demonstration will pave the way for development of a wireless telemetry to enable a wireless mBTS for chronic animal studies. The non-contact sensing method also can be applied to other synthetic vascular grafts or drainage shunts. This proposal will establish proof-of-concept that is critical to achieve the long term goal of a wirelessly interrogated flow sensor system for periodic monitoring in a home care setting that enables early warning to drive intervention that saves lives. |
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2021 — 2025 | Meng, Ellis Molisch, Andreas (co-PI) [⬀] Sideris, Constantine |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
@ University of Southern California Brain Machine Interfaces (BMI) are used to record the electrical signals of the neurons in the brain and gain insights into the complex processes occurring in the brain and nervous system. This understanding is crucial to repair or augment cognitive and/or sensory and motor functions, which might be necessary, e.g., due to damage to the brain sustained by injuries or diseases. Traditional recording by electroencephalography (EEG) or functional magnetic resonance imaging (MRI) is too crude, cumbersome, and slow for many of these tasks; therefore, BMIs with implanted microelectrodes need to be used. However, state of the art implantable electrode arrays (IEAs) made from rigid silicon not only have short lifetimes but can also damage the brain tissue and cause scar formation. Recently, IEAs have been developed using flexible polymer-based shanks which minimize tissue damage during implantation, significantly increasing safety and paving the way towards long-term recording. Unfortunately, the number of electrodes, and thus the amount of data that can be recorded, is very limited. To pave the way for new basic science discoveries in neuroscience and the development of new, safe BMIs to treat individuals with brain injury or disease, this project introduces a new, completely wireless approach that has virtually unlimited data bandwidth for communicating data outside of the brain and enables safe, long term brain recording via biocompatible, flexible polymer electrodes. The system is expected to have a huge impact on advancing the state-of-the-art in IEA technology by enabling, for the first time ever, safe and high-density neural recording over multiple year-long durations. The technological advances in hybrid silicon-polymer fabrication and chip-to-chip communication via polymer waveguides will also hold scientific and practical application value in their own right. |
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