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According to our matching algorithm, Margaret E. Kemeny is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
1989 — 1999 |
Kemeny, Margaret E |
K01Activity Code Description: For support of a scientist, committed to research, in need of both advanced research training and additional experience. K02Activity Code Description: Undocumented code - click on the grant title for more information. |
Psychoneuroimmunology and Hiv Infection @ University of California Los Angeles
This proposal is a request for an ADAMHA RSDA level focused on psychoneuroimmunology at the University of California, Los Angeles. The RSDA would be sponsored by Herbert Weiner, M.D., Professor of Psychiatry and John L. Fahey, M.D., Professor of Microbiology and Immunology and Director of the Center for Interdisciplinary Research on Immunology and Disease (CIRID). My goals for the RSDA period are: 1) increased understanding of methodological and conceptual issues in immunology, with an emphasis on immunopathology related to the Human Immunodeficiency Virus (HIV), 2) increased understanding of methodological and conceptual issues in biobehavioral sciences, 3) continued research on psychological processes as cofactors in the progression of HIV infection, and 4) to begin collaborative research on the biological pathways that underlay the relationship between psychological factors and changes in immunity. The primary objective of my research during the RSDA period will be to determine if particular psychological responses to exposure to two stressful experiences (the risk of developing AIDS and bereavement) are associated with immune processes prognostic for the development of AIDS, as well as a more rapid development of AIDS in HIV+ ran who participate in the Los Angeles Multi-Center AIDS Cohort Study (MACS). In addition, the project would begin to test two biological pathways that may link psychological processes to changes in immunity in HIV+ men: reactivation of latent viruses and altered susceptibility of lymphocytes to stimulation by lymphocytes and neuropeptides. My long-term goal is to direct interdisciplinary research on the relationships among psychological factors, immune processes and the progression of latent or chronic viral infections, particularly infection with HIV. I intend this research to move in the direction of isolating biological pathways that underlay relationships between particular dimensions of psychological response to threatening events and particular patterns of immunological response.
|
0.972 |
1990 — 1994 |
Kemeny, Margaret E |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Psychosocial Processes as Cofactors in Aids @ University of California Los Angeles
The overall objective of this study is to explore psychosocial processes as possible cofactors in the development of the acquired immune deficiency syndrome (AIDS) in an at-risk population. The specific objectives are: 1) to understand how individuals appraise, respond emotionally to and cope with the risk of developing AIDS, 2) to determine if particular psychological responses to the risk of AIDS are associated with the practice of AIDS risk-reducing behaviors, 3) to determine if particular psychological responses to the risk of AIDS are associated with changes in the immune system (rapid reductions in helper/inducer T cell levels, and altered immune response to the AIDS virus) and increased likelihood of developing AIDS and 4) to determine if exposure to stressful life situations and particular psychological responses to these situations, are associated with immune changes and increased likelihood of developing AIDS. Fifteen hundred healthy homosexual men are now participating in the Multi-Center AIDS Cooperative Study (MACS). These men are examined every six months for signs and symptoms of AIDS and the AIDS-Related Complex (ARC), seropositivity for the human immunodeficiency virus (HIV), specimen collection and assay of T cell sub-populations, and the gathering of data on potential cofactors in the development of AIDS. The proposed study will add the questionnaire assessment of psychosocial factors (appraisal and response to AIDS risk, other life stress, affect, social support, personal resources) to the examination every six months. A sub-sample of two hundred subjects will participate in a psychological assessment interview at each MACS examination to assess more fully emotional responses and coping strategies used in relation to the AIDS risk and other stressful situations. Intensive immunological assessments will be conducted on this sub-sample. Data analyses will determine whether psychological factors predict the practice of risk-reducing behaviors in HIV seropositive and seronegative subjects. In HIV seropositive individuals, data analyses will determine whether psychosocial factors, in conjunction with other possible cofactors, predict changes in immune response over time and the development of ARC and AIDS.
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0.972 |