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High-probability grants
According to our matching algorithm, Kurt R. Illig is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
2000 — 2001 |
Illig, Kurt R |
F32Activity Code Description: To provide postdoctoral research training to individuals to broaden their scientific background and extend their potential for research in specified health-related areas. |
Information Processing in Piriform Cortex @ University of Wisconsin Madison
In contrast to other sensory systems, very little is known about information processing in the olfactory system. In part, this stems from a paucity of research that has been conducted on the physiological nature of primary olfactory cortex (piriform cortex). The experiments in this proposal will use electrophysiological and molecular biological to answer fundamental questions regarding the functional organization of olfactory cortex. In particular, the apparent spatial organization of input fibers to piriform cortex suggests, at least at early stages of cortical processing, a spatial representation of odors is preserved, despite the lack of evidence for such organization in some previous studies. Systematic in vitro multi-electrode electrophysiology is planned to investigate odor-specific responses in piriform cortex to determine the functional organization of this area. Experiments to determine whether groups of cells exhibit a response-based topography, using in situ hybridization to visualize immediate early gene expression, are planned to support flu results of electrophysiology studies. Results from the proposed experiments will help to define the nature of olfactory stimulus representation at the cortical level, and explore the functional roles of anatomically-defined subregions in piriform cortex.
|
0.958 |
2005 — 2007 |
Illig, Kurt R |
R03Activity Code Description: To provide research support specifically limited in time and amount for studies in categorical program areas. Small grants provide flexibility for initiating studies which are generally for preliminary short-term projects and are non-renewable. |
Spatial Aspects of Coding in Piriform Cortex @ University of Virginia Charlottesville
DESCRIPTION (provided by applicant): The time is approaching when our understanding of mammalian olfactory function will be limited by the gaps in our knowledge of the olfactory cortex. The experiments in this proposal will build on previous work concerning spatial aspects of olfactory coding in rat piriform (olfactory) cortex. Based on existing anatomical and physiological evidence, and on findings from computational models, the working hypothesis is that the spatially ordered representation of odors in the OB is transformed into a broadly structured, spatially-distributed ensemble code in the posterior piriform cortex (PPC) by way of a spatially-complex, hybrid representation in the anterior piriform cortex (APC). Evaluation of this hypothesis will use double-labeling techniques that utilize in situ hybridization of immediate-early gene expression to visualize cells which have been activated by odor stimulation. The Specific Aims will test a series of predictions that relate to spatial aspects of olfactory coding in different subdivisions of the piriform cortex. The results will provide insight into mechanisms that underlie olfactory stimulus coding and discrimination in the mammalian brain. In view of certain advantageous structural features and a putative role in associative memory, the findings for piriform cortex also may provide insight into more general issues of cortical function, including mechanisms for complex pattern recognition, multimodal integration, and learning and memory.
|
0.958 |