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High-probability grants
According to our matching algorithm, Amico Bignami is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
1985 — 1987 |
Bignami, Amico |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Brain Specific Protein (Gfa Protein) in Astrocytes @ Harvard University (Medical School)
GFA protein is the subunit of glio-specific filaments and a major product of astroglial differentiation. GFA protein is of particular interest for studies of the astroglial response to injury characterized by the accumulation of cytoplasmic filaments (fibrous gliosis). The study proposes: i, to conduct comparative biochemical, biophysical and immunological investigations of GFA protein and other intermediate filament proteins also present in astroglia; ii, to study turnover of GFA protein in vivo and in vitro; iiim to conduct experiments aimed at characterizing cytoskeletal transitions during differentiation in vivo and in vitro and following brain injury; iv, to conduct detailed morphological studies of glio-axonal interactions in CNS regeneration induced by peripheral nerve implants. Finally, the specificity of GFA protein for astroglia will be re-assessed following a recent report describing the presence of GFA protein in Schwann cells (peripheral glia). It is hoped that these studies will lead to a greater understanding of the role of neuroglia in neurological diseases.
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1 |
1988 — 1993 |
Bignami, Amico |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Brain Specific Protein--Gfa Protein in Astrocytes @ Harvard University (Medical School)
The study of intermediate filament (IF) post-translational modifications will constitute a major effort in the next grant period. IF proteins have provided a valuable tool for the purpose of cell identification due to their specificity for the main tissues forming the body (epithelia, mesenchyma, muscle, glia and neurons). However, the IF function still remain elusive and it is hoped that a study of post-translational modifications may provide some clues in this respect. The hypothesis is that these modifications may account for structural maturation by stabilizing the final shape of glia and neurons, including their processes. The study of hyaluronate-binding proteins in mature and immature CNS is the other major goal of this project. The remarkable transition from fibroblast-type IF (vimentin) to astrocyte-specific IF (GFA protein) occurring at the time of glial differentiation, suggested that immature glia display mesenchymal properties relevant to morphogenesis such as the production of an extracellular matrix playing a role in cell migration and axonal growth, and that the loss of these properties following differentiation may account for the lack of regeneration in mature spinal cord. Preliminary observations are consistent with this hypothesis. We have identified in mature CNS a brain-specific hyaluronate-binding protein produced by white matter (but not gray matter) astrocytes. Conversely, other hyaluronate-binding fractions co-localized in brain and mesenchyma during embryonal development.
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1 |