Area:
Behavoral Neuroscience, Alcohol abuse and addiction
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High-probability grants
According to our matching algorithm, Jaime L. Diaz-Granados is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
2000 — 2003 |
Diaz-Granados, Jaime L |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Adolescent Etoh Exposure: Effect On Adult Etoh Response
Alcohol use and abuse is prevalent among adolescents. Alcohol remains to be the primary drug of choice among this population. However, due to ethical considerations, it is impossible to investigate the effects of adolescent alcohol exposure in the human population. Therefore, animal models must be utilized to examine the effects of alcohol exposure during this developmental period. Recent preliminary data from our laboratory suggests that exposure to alcohol during adolescent development attenuates the adult's initial response to ethanol-induced ataxia. In addition, preliminary results from our laboratory suggest that adolescent alcohol exposure exacerbates the alcohol withdrawal response in adulthood. The overall objective of this proposal is to investigate more fully whether exposure to alcohol during the adolescent period will alter the pharmacological response to alcohol in adulthood. Specifically, the proposed work will examine the effect of adolescent alcohol exposure on (1) the adult's initial response to the intoxicating effects of alcohol, (2) the development of rapid tolerance to the intoxicating effects of alcohol, (3) the development of chronic tolerance to the ataxic and hypothermic effects of alcohol, and (4) the severity of the alcohol withdrawal reaction. Specific aim 1 will address the sensitivity of these responses to the level of intoxication achieved during adolescence. The second specific aim will examine whether exposure to alcohol during early, middle, and late periods of adolescent development will result in differential effects on the adult response to alcohol. Specific aim 3 will investigate whether the pattern of alcohol exposure (i.e., chronic versus intermittent) will differentially alter the adult response to alcohol. Findings from these studies will significantly characterize the effects of the dose, timing, and pattern of alcohol exposure during adolescence on later responsiveness to ethanol in adulthood. This requisite characterization of adolescent developmental alcohol effects, coupled with the known ontogeny of neural systems during the adolescent period, should lead to further investigation of possible alcohol-induced perturbations of the developing central nervous system which may underlie an altered adult response to alcohol.
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1 |
2005 — 2006 |
Diaz-Granados, Jaime L |
R21Activity Code Description: To encourage the development of new research activities in categorical program areas. (Support generally is restricted in level of support and in time.) |
Taurine: Osmoregulation and Etoh Withdrawal Attenuation
[unreadable] DESCRIPTION (provided by applicant): Ethanol-induced neurological changes produce aversive withdrawal symptoms that often promote further ethanol abuse as a way of suppressing these unwanted conditions. Investigations designed to examine therapeutic interventions of ethanol withdrawal are clinically relevant in that they may result in a reduction in the probability of further abuse [unreadable] episodes. Although most alcohol research, to date, has focused primarily upon ethanol-induced disruptions in neurotransmitter homeostasis, changes in the neuroendocrine control of systemic osmolarity also appear to exist as a contributing factor of withdrawal severity. However, the p-amino acid taurine, with recognized functions in osmoregulation and neuroinhibition via GABA and glycine receptors, might ameliorate these ethanol-provoked alterations and reduce overall withdrawal severity. The proposed investigation will examine the possible therapeutic effect of taurine in alleviating ethanol withdrawal as determined by measures of withdrawal-related handling-induced convulsions. The design of the experiments will allow the dissociation of taurine's action via osmoregulation and/or neuroinhibition in male C3H mice made ethanol dependent through chronic exposure to ethanol vapors. In addition, levels of arginine vasopressin, taurine, and GABA will be measured in the highly osmosensitive supraoptic nucleus of the hypothalamus, pituitary, and hippocampus. Results from these studies could provide evidence that supports the therapeutic use of taurine in alcoholism and lead to further investigations of the therapeutic use of this amino acid. [unreadable] [unreadable]
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1 |