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High-probability grants
According to our matching algorithm, Jennifer F. Linden is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
1999 — 2001 |
Linden, Jennifer F |
F32Activity Code Description: To provide postdoctoral research training to individuals to broaden their scientific background and extend their potential for research in specified health-related areas. |
Laminar Comparison of Plasticity in Auditory Cortex @ University of California San Francisco
The objective of this research is to determine how receptive field plasticity in mouse auditory cortex varies across cortical layers. The central hypothesis is that neuronal receptive fields in supra- and infra-granular layers of auditory cortex are complex, highly dynamic transformations of simpler, more stable responses in layer IV. By testing this hypothesis, the proposed experiments will contribute to the development of a model of intracolumnar processing and plasticity in mouse neocortex. The research will proceed in three stages. First, spectrotemporal receptive fields (STRFs) of auditory cortex neurons in different cortical layers will be characterized in awake mice, to see if auditory responses of neurons in supra- and infra-granular layers are more complex than those of neurons in layer IV. Second, the effects of behavioral conditioning on auditory responses in different cortical layers will be examined, to determine whether the STRFs of neurons in supra-and infra-granular layers are more strongly modified by training than those of neurons in layer IV. Third, the effects of nucleus basalis stimulation on auditory responses in different cortical layers will be studied. Nucleus basalis stimulation increases cholinergic input to auditory cortex and induces dramatic plasticity in neuronal receptive fields. This final experiment will describe not only how cholinergic input modifies STRFs in different cortical layers, but also how the layer-specific effects of nucleus basalis stimulation compare to the layer-specific effects of behavioral conditioning.
|
0.936 |
2003 |
Linden, Jennifer F |
R03Activity Code Description: To provide research support specifically limited in time and amount for studies in categorical program areas. Small grants provide flexibility for initiating studies which are generally for preliminary short-term projects and are non-renewable. |
Auditory Cortical Processing and Plasticity in the Mouse @ University of California San Francisco
[unreadable] DESCRIPTION (provided by applicant): The objective of this research is to understand how auditory information is transformed within cortical columns and how this transformation is modified by auditory experience and learning. This objective will be pursued through studies of auditory cortical processing and plasticity in the mouse, in order to establish a model system for future experiments that will exploit powerful genetic techniques now available for manipulating cortical circuitry in mice. The proposed investigations involve three specific aims: (1) To characterize the transformations of auditory information occurring within cortical columns in mouse auditory cortex, spectrotemporal receptive fields (STRFs) of neurons in supragranular, infragranular, and thalamorecipient layers of primary auditory cortex (A1) and anterior auditory field (AAF) will be compared. Extracellular neuronal recordings will be obtained during presentation of spectrally rich, temporally complex acoustic stimuli and STRFs will be determined by reverse-correlation analysis. (2) To examine how auditory experience during development might modify the transformations of auditory information within cortical columns, STRFs from adult mice reared in a quiet acoustic environment will be compared to STRFs from mice exposed during development to stimuli composed of upward and downward frequency sweeps. Variations in STRFs across cortical layers and between areas A1 and AAF will be analyzed for both groups of animals, to identify changes in cortical processing induced by early experience. (3) To determine how auditory learning modifies intracortical transformations of auditory information, STRFs from adult mice trained to discriminate stimuli composed of upward and downward frequency sweeps will be compared to STRFs from mice exposed to the same stimuli but not trained to discriminate them. Differences in STRFs between cortical layers and between cortical areas A1 and AAF will again be analyzed for both groups of animals, to define the changes in cortical processing induced by auditory learning. Ultimately, the results of these three experiments in normal mice are intended to provide a framework for future planned experiments in genetically engineered mice, experiments that will be aimed at defining the roles of different cortical cell types in cortical processing and plasticity, and at identifying the cortical causes and consequences of neurological and neuropsychiatric disease. [unreadable] [unreadable]
|
0.936 |