Area:
Experimental Psychology
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High-probability grants
According to our matching algorithm, Megan E. Roth is the likely recipient of the following grants.
| Years |
Recipients |
Code |
Title / Keywords |
Matching
score |
| 2001 — 2002 |
Roth, Megan E |
F31Activity Code Description:
To provide predoctoral individuals with supervised research training in specified health and health-related areas leading toward the research degree (e.g., Ph.D.). |
Effects of Sex and Estrogen On Drug Self-Administration @ University of Minnesota Twin Cities
DESCRIPTION: (provided by applicant) This proposal was designed to examine the effects of sex and estrogen on the self-administration of intravenously (i.v.) delivered drugs in rats. Four animal models will be used to investigate acquisition, maintenance, regulation/dysregulation, and reinstatement of drug self-administration. The effects of sex and estrogen on the acquisition of heroin, methamphetamine and d, 1-3, 4-methylenedioxymethamphetamine (MDMA) self-administration will be examined using an autoshaping procedure. A progressive ratio (PR) schedule of reinforcement and a behavioral economic analysis of demand will be used to evaluate the effects of sex and estrogen on the maintenance of cocaine and heroin self-administration. Breakpoint (BP) measures obtained on a PR schedule, along with slopes and P-max values obtained from demand curves will be used to evaluate the reinforcing efficacy of several doses of cocaine and heroin. Differential access to cocaine self-administration will be used to investigate the effect of sex on the regulation/dysregulation of cocaine intake. Dose-response curves for cocaine will be obtained to examine group differences in shifts in the dose-response curves. The effect of estrogen on the reinstatement of cocaine self-administration will be examined using a priming model of drug reinstatement in which lever pressing for drug is extinguished by replacing cocaine infusions with saline infusions. Reinstatement of responding is then tested by administering a priming injection of cocaine.
|
1 |
| 2004 |
Roth, Megan E |
F32Activity Code Description:
To provide postdoctoral research training to individuals to broaden their scientific background and extend their potential for research in specified health-related areas. |
Primate Model of Drug Abuse: Gender and Hormonal Effects @ University of Minnesota Twin Cities
DESCRIPTION (provided by applicant): This proposal was designed to examine the effects of gender and menstrual cycle phase on oral and smoked drug self-administration in rhesus monkeys. A goal of the proposed experiments is to extend findings indicating gender and hormonal influences on drug abuse from rodent studies to nonhuman primates using experimental conditions similar to those that elucidate effects of these factors in rodents. Progressive ratio (PR) schedules and a behavioral economic analysis of demand will be used to evaluate the effects of gender and menstrual cycle phase on oral phencyclidine (PCP) and cocaine self-administration. The effects of gender on the escalation of cocaine intake will be examined using a differential access procedure that allows animals short- (1-hr) or long- (6-hr) access to drug self-administration. Following the differential access procedure, gender and menstrual phase differences in the reinforcing effectiveness of cocaine will be assessed using a PR schedule. A PR schedule and demand curve analysis will also be used to determine the relative reinforcing effectiveness of smoked cocaine and methamphetamine in males vs. females and during specific phases of the menstrual cycle.
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1 |