Area:
Neuroscience Biology
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High-probability grants
According to our matching algorithm, Wayne J. Korzan is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
2001 — 2003 |
Korzan, Wayne Joseph |
F31Activity Code Description: To provide predoctoral individuals with supervised research training in specified health and health-related areas leading toward the research degree (e.g., Ph.D.). |
Visual Signals and Social Behavior @ University of South Dakota
DESCRIPTION (provided by applicant): The objective of the proposed experiments is to determine the neuroendocrine mechanisms linking aggression, social status and stress. In humans and other vertebrates, stress from aggression or low social status results in highly modified behavior and emotional dysfunction, such as depression. A model system with relatively simple behavior and a visible indicator of stress responsiveness, provides a mechanism for studying complex integration of autonomic and limbic systems with brainstem monoamine perikarya and peripheral stress responses. In Anolis carolinensis, a unique sign stimulus, the formation of postorbital eyespots, appears to be directly related to social status. Therefore, altering the formation of the eyespot using either physical or pharmacological manipulations should influence social status. Specific Aims: This proposal will ivestigate four related objectives. The first objective is to determine the relative influence of the eyespot as a social signal. Second, determining the value of the eyespot as a social signal in previously established social hierarchies adds the test of reversal of dominance. The eyespot, as a social signal, may override previously established social status. Third, is determining the relationships among eyespot formation, aggression and monoamine release in hippocampus, testing if in specific nuclei (e.g. hippocampus) 5-HT and DA are inversely related to one another with respect to behavior. Microdialysis will be utilized to measure serotonergic and dopaminergic activity during aggressive interactions. The fourth objective is to learn if there is a direct reciprocal regulation of hippocampal dopamine and serotonin.
|
1 |
2005 — 2007 |
Korzan, Wayne Joseph |
F32Activity Code Description: To provide postdoctoral research training to individuals to broaden their scientific background and extend their potential for research in specified health-related areas. |
Social Regulation of Gnrh Release
DESCRIPTION (provided by candidate): The proposed experiments are designed to understand how social interactions produce functional changes in the central nervous system. As a model system for studying this work, I will use an African cichlid fish species, Haplochromis burtoni, in which previous work has shown that the size of gonadotropin releasing hormone (GnRH) neurons in the preoptic area (POA) in males depends on social status. Dominant males have large GnRH neurons with elaborated processes while non-dominant animals have small neurons with reduced processes. The size and neural activity of these GnRH neurons corresponds directly with the individual's reproductive potential, namely dominant males can reproduce while non-dominant animals cannot. However, the neural mechanisms through which social and environmental conditions regulate GnRH neurons and hence reproduction are not known. In many species, changes in levels of the neurotransmitters serotonin (5-HT) and dopamine (DA) are related to changes in behavior and social (e.g. rank and reproductive) status. Moreover, 5-HT cells and fibers have been found in close proximity to GnRH neurons in the preoptic area (POA) as has also been shown for dopamine immunoreactive neurons in teleost fish, amphibians and birds. Recently, dopamine has been shown to influence the electrical activity of GnRH cells in the POA of Haplochromis burtoni. The experiments proposed here are designed to understand the role of serotonin and dopamine in regulating behavior, social rank and GnRH neuron size and activity. The expected results will contribute to our understanding of how neural plasticity both control and depend on social behavior.
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0.954 |