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High-probability grants
According to our matching algorithm, Jason B. Castro is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
2006 — 2007 |
Castro, Jason B |
F31Activity Code Description: To provide predoctoral individuals with supervised research training in specified health and health-related areas leading toward the research degree (e.g., Ph.D.). |
Dendritic Integration in Multi-Tufted Mitral Cells @ University of Pittsburgh At Pittsburgh
[unreadable] DESCRIPTION (provided by candidate): The overall goal of this project is to understand how multitufted mitral cells of the accessory olfactory bulb (AOB) generate selective outputs for only specific combinations of strain and sex. Although receptor properties certainly contribute to mitral cell selectivity, the ability of any neuron to recognize and respond to certain combinations of features depends fundamentally on dendritic integration. Toward this end, we will investigate temporal and spatial integration properties in AOB mitral cells using a combination of in vitro whole cell physiology and calcium imaging. This will contribute to our knowledge of the computational mechanisms and strategies that neurons use to generate responses that are selective for specific activity patterns. By deepening our understanding of how sensory neurons process information and represent the world, we may ultimately be able to identify therapeutic targets for diseases that affect peripheral processing in the chemical senses, as well as others. [unreadable] [unreadable] [unreadable]
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1 |
2011 |
Castro, Jason B |
F32Activity Code Description: To provide postdoctoral research training to individuals to broaden their scientific background and extend their potential for research in specified health-related areas. |
Mechanism of Plasticity in An Auditory Brainstem Nucleus @ University of Pittsburgh At Pittsburgh
DESCRIPTION (provided by applicant): The goal of this work is to investigate physiological mechanisms mediating the development and refinement of synapses in the lateral superior olive (LSO). The LSO is a binaural auditory brainstem nucleus whose principal neurons receive excitation and inhibition from distinct nuclear sources. Following a developmental program of functional and anatomical synaptic refinement, excitatory and inhibitory afferents to the LSO are tonotopically organized and frequency matched in the mature rodent. These unique conditions make the LSO a model system for studying how mechanisms of excitatory and inhibitory plasticity may be coordinated to produce appropriately balanced neural circuits. This proposal builds on our preliminary work demonstrating the striking and unexpected necessity of hyperpolarization for long-term potentiation of excitatory synapses in the LSO, and outlines a series of experiments to test mechanisms mediating this novel form of plasticity. PUBLIC HEALTH RELEVANCE: This goal of this project is to provide insight into the cellular mechanisms underlying the formation of precise neuronal connections in the mammalian auditory system. Studying these mechanisms will lead to a better understanding of causes and potential treatments of auditory processing disorders such as developmental dyslexia, speech processing impairments, and autism.
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1 |