2003 — 2005 |
Jones, Jana E |
F32Activity Code Description: To provide postdoctoral research training to individuals to broaden their scientific background and extend their potential for research in specified health-related areas. |
Depression in Temporal Lobe Epilepsy @ University of Wisconsin Madison
[unreadable] DESCRIPTION (provided by applicant): [unreadable] The proposed study would be the first controlled prospective investigation of the incidence and predictors of depressive disorders in individuals with chronic temporal lobe epilepsy (TLE). Beginning four years ago, a large cohort of individuals with TLE and healthy controls underwent a baseline psychiatric interview, MRI, cognitive testing, and assessment of quality of life. For this project, a consecutive series of individuals with TLE and controls (n = 118) will be seen four years later in order to: 1) determine the prospective incidence and relative risk of DSM-IV major depression and other depressive disorders in chronic TLE compared to controls; 2) identify the psychiatric, stressful life events, MRI, and clinical epilepsy variables predictive of prospective episodes of major depression and other depressive disorders over the interval; 3) identify the incidence of depressive episodes which meet the DSM-IV-TR criteria for minor depressive disorder and recurrent brief depressive disorder. The methodology will include: l) a comprehensive standardized psychiatric re-interview of DSM-IV Axis I disorders (SCID); 2) identification of stressful life events that occurred over the interval; and 3) review of medical records with participant interview to determine change in interval regarding seizure frequency and treatment. This study will make a significant contribution to understanding a major psychiatric complication in epilepsy and will integrate psychosocial, neurobiological, and clinical factors to provide a more comprehensive understanding of depressive episodes in epilepsy. [unreadable] [unreadable] [unreadable]
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2019 |
Hermann, Bruce Phillip (co-PI) [⬀] Jones, Jana E |
R56Activity Code Description: To provide limited interim research support based on the merit of a pending R01 application while applicant gathers additional data to revise a new or competing renewal application. This grant will underwrite highly meritorious applications that if given the opportunity to revise their application could meet IC recommended standards and would be missed opportunities if not funded. Interim funded ends when the applicant succeeds in obtaining an R01 or other competing award built on the R56 grant. These awards are not renewable. |
Neuropsychological Progression in New Onset Epilepsy @ University of Wisconsin-Madison
Our controlled prospective cohort study (RO1-44351) examined children (ages 8-18) with newly diagnosed childhood epilepsies (n=183) and healthy controls (n=107) with neuropsychological, neuroimaging and psychiatric assessments. This competing renewal application proposes that four prevalent neurobehavioral comorbidities (Academic Problems, ADHD, Anxiety, Depression) are not merely consequences of epilepsy syndrome type, course, treatment, or societal stigma, but represent fundamental phenotypes of the childhood epilepsies. These phenotypes are associated with altered neurodevelopmental processes occurring antecedent to seizure onset and at epilepsy diagnosis. We posit that neurobehavioral comorbidities are associated with abnormal baseline and prospective cognitive and neuroimaging findings and are predictive of long-term psychosocial outcomes. A critical corollary is that children with epilepsy who at epilepsy diagnosis are without these four neurobehavioral comorbidities are comparable to healthy peers in cognition and brain structure, prospective cognitive and brain development, and long term life outcomes. This view challenges the conventional wisdom regarding what constitutes the ?benign? epilepsies (i.e., not epilepsy syndrome and course but the presence/absence of key comorbidities). This view carries fundamental implications for clinical care, and offers to merge two disparate lines of research in the childhood epilepsies by proposing that the problematic long term psychosocial outcomes of the idiopathic childhood epilepsies are linked primarily to the neurobehavioral comorbidities. In this competing renewal application we propose to complete the follow-up of our entire cohort (n=290) in order to characterize the pattern of shared and unique risk of neurobehavioral comorbidities across epilepsy syndromes from baseline to 5-years after diagnosis (Aim 1), determine patterns of brain and cognitive development associated with neurobehavioral comorbidities from baseline to 5-years after diagnosis (Aim 2); and determine whether divergent psychosocial outcomes in young adulthood, 10-years after diagnosis, are predicted by baseline neurobehavioral comorbidity status compared to epilepsy syndrome (Aim 3).
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