Area:
Neuroscience Biology
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High-probability grants
According to our matching algorithm, Jeremy R. Edgerton is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
2001 — 2003 |
Edgerton, Jeremy R |
F31Activity Code Description: To provide predoctoral individuals with supervised research training in specified health and health-related areas leading toward the research degree (e.g., Ph.D.). |
Ca2+ Activated K+ Channels Regulate Purkinje Cell Firing
DESCRIPTION(As provided by Applicant): This project is intended to provide a better understanding of how specific ion channel types regulate the function of mammalian neurons. Such knowledge has been and will continue to be essential for the development of more potent and specific drugs to treat neurological disorders, and will enable scientists to gain a more thorough understanding of congenital diseases resulting from ion channel mutations. The project focuses on a family of ion channels called calcium-activated potassium channels (Kca channels), and on the contribution of this channel family to the function of a well-characterized type of mammalian neuron, the Purkinje neuron of the cerebellum. The project will proceed by addressing the following two specific aims. Aim 1: Determine the contribution of Kca channels to Purkinje neuron excitability. The electrical activity of rat Purkinje neurons will be monitored using the patch clamp technique. KCa channel activity will be manipulated with commercially available blockers and agonists, and the effects on sodium action potentials and dendritic calcium spikes will be assessed. The distribution of KCa channels on the soma and along the dendrite will be estimated using single channel, cell-attached patch recordings. Aim 2: Determine what specific routes of calcium entry activate Kca channels in Purkinje neurons. Electrophysiological methods will be used to examine the consequences of calcium channel blockers on Purkinje cell Kca activity.
|
1 |
2006 — 2008 |
Edgerton, Jeremy R |
F32Activity Code Description: To provide postdoctoral research training to individuals to broaden their scientific background and extend their potential for research in specified health-related areas. |
Synaptic Control of Spiking in Rat Globus Pallidus
[unreadable] DESCRIPTION (provided by applicant): This project addresses the question of how synaptic inputs from the striatum and subthalamic nucleus control the spiking output of globus pallidus neurons. Multiple subpopulations of GABAergic neurons coexist in the GP, and evidence indicates that the electrophysiological properties and modes of synaptic integration differ across GP neuron subtypes. To understand how synaptic inputs control spiking in different GP neurons, a combination of electrophysiological, histological and computational approaches will be used to address the following two specific aims. Aim 1: to characterize the responses of GP neuron subtypes to excitatory and inhibitory synaptic inputs. Synaptic responses are characterized electrophysiologically. Neurons are post- processed immunohistochemically to determine which subpopulation they belong to. Aim 2: to determine how differing intrinsic properties influence synaptic integration in GP neuronal subpopulations. The intrinsic properties of each subtype will be characterized in detail. For both aims, biophysically realistic computer models are constantly refined according to the physiology data and used to make predictions about how the different neuronal subpopulations are likely to respond to complex, in vivo-like patterns of synaptic input. [unreadable] [unreadable]
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0.97 |