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High-probability grants
According to our matching algorithm, Jeremy S. Duncan is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
2014 — 2015 |
Duncan, Jeremy S |
F32Activity Code Description: To provide postdoctoral research training to individuals to broaden their scientific background and extend their potential for research in specified health-related areas. |
Transcription Factor Patterning of the Vestibular Maculae
DESCRIPTION (provided by applicant): Although there are several sources of vestibular dysfunction, many causes such as viral disorders, antibiotic toxicity, autoimmune disease, and degenerative disorders can all result in hair cell loss. Complete recovery may be possible for these individuals through regeneration of missing vestibular hair cells. Morphological differences between hair cells in different regions of the vestibular maculae enable them to respond to specific aspects of motion, and are necessary for normal vestibular function. These variations are likely to be regulated by transcription factors, and reflect the regional patterning of individal sensory organs. The research goal of this proposal is to identify regional differences in transcription factor expression, and determine how these genes contribute to hair cell heterogeneity. One aspect of regional variation is the division of both the utricle and saccule int two regions with oppositely oriented stereocilia. We have utilized a transgenic mouse line to segregate these two populations, and have identified a set of transcription factors with differences in regional expression by RNA-seq. I will analyze the spatial and temporal expression patterns of these transcription factors and further characterize their cell type expression. The function of these genes will be interrogated by both overexpression in vitro and by analyzing knock-out mice. This assay will assess the role of these genes in stereociliary bundle orientation, changes in gene expression, and alterations in afferent innervation. The proposed study will allow us to validate regional variations in transcription factor expression, shed light on the function of these genes, establish a molecular research background in the candidate, and help the applicant move toward an independent, productive, fulfilling career.
|
0.976 |
2019 — 2021 |
Duncan, Jeremy S |
R21Activity Code Description: To encourage the development of new research activities in categorical program areas. (Support generally is restricted in level of support and in time.) |
Determining the Molecular Landscape Necessary For Hair Cell Differentiation @ Western Michigan University
PROJECT SUMMARY Hair cells within the inner ear transform sound stimuli into electrical impulses to then be transmitted to the brain by afferent neurons. Hearing is lost in individuals where hair cells are absent or dysfunctional hearing is lost. One of the major hurdles in hair cell restoration is that after hair cell death, the sensory organ of Corti is eventually replaced by a flat cuboidal epithelium. Pst research has shown that these cells are not receptive to transdifferentation into hair cells. Therefore, it is critical to define the molecules that give rise to the prosensory epithelia and provide the underlying gene regulatory network that support transcription factors involved in hair cell differentiation. Towards this end, we have identified early otic Gata3 expression is necessary for prosensory specification and hair cell differentiation. In addition, the level of Gata3 is severely reduced in the flat epithelium that replaces the organ of Corti after hair cell loss. Gata3 continues to be expressed in the developing prosensory epithelia and hair cells as they differentiate, however, its later expression during these events has not been characterized. Based upon these observations, we hypothesize that the continued expression of precise levels of Gata3 are continually needed during the development and differentiation of prosensory epithelia and hair cells. We will test this hypothesis by investigating 1) the loss of Gata3 during these time points and its effect on the specification of cells to adopt a prosensory fate and on hair cells to correctly differentiate, 2) increased expression of Gata3 during these time points and how this increased level effects these cell types, and 3) if Gata3 expression can alter the flat epithelium into a more sensory like state. Finally, this research will lay the foundation and provide preliminary data for a subsequent R01.
|
0.957 |