Area:
Molecular Biology, Neuroscience Biology, Zoology Biology
We are testing a new system for linking grants to scientists.
The funding information displayed below comes from the
NIH Research Portfolio Online Reporting Tools and the
NSF Award Database.
The grant data on this page is limited to grants awarded in the United States and is thus partial. It can nonetheless be used to understand how funding patterns influence mentorship networks and vice-versa, which has deep implications on how research is done.
You can help! If you notice any innacuracies, please
sign in and mark grants as correct or incorrect matches.
Sign in to see low-probability grants and correct any errors in linkage between grants and researchers.
High-probability grants
According to our matching algorithm, Pamela L. Larsen is the likely recipient of the following grants.
| Years |
Recipients |
Code |
Title / Keywords |
Matching
score |
| 1998 |
Larsen, Pamela L |
R03Activity Code Description:
To provide research support specifically limited in time and amount for studies in categorical program areas. Small grants provide flexibility for initiating studies which are generally for preliminary short-term projects and are non-renewable. |
Gene Expression in C Elegans @ University of Southern California
Genes that regulate dauer larva development and life span have been identified in the nematode C. elegans. This free-living soil nematode has a three day generation time, a two-week life span, and displays traits seen in other senescent animals. The age-1 gene, which when mutated increases life span, has been placed in the middle of the genetic pathway for life span determination in C. elegans. Recently, this gene has been cloned and shows homology to phosphatidylinositol-3- OH kinases and thus is likely to function as a regulator in this pathway. In addition, several enzyme activity levels have been measured in long-lived mutants and found to differ in comparison to those of wild-type animals. However, no mechanistic link has been established between the regulator and these candidate longevity effector genes which have been shown to increased or decreased enzyme activity levels. The goal of this proposal is to initiate identification of the regulation point which gives rise to increased activity. The steady-state mRNA and protein levels of candidate longevity effector genes will be ascertained in dauer larvae, wild-type adults and Age adults. The long-lived adult state and the dauer state are similar, yet different for genetic traits and a couple of enzyme activity levels. Therefore, the candidate longevity effector genes will be sorted with regard to which activities are necessary for the extended longevity. This analysis could reveal similarly controlled effector genes and from these consensus regulatory elements could be derived and a search for other in the genomic database conducted. Ultimately, the addition of verified components involved will result in a detailed mechanistic model of the control and execution of life span extension.
|
1 |