1982 — 1984 |
Satterlie, Richard |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Neuronal Control of Locomotion in Medusae @ Arizona State University |
1 |
1986 — 1989 |
Satterlie, Richard |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Roa: Pattern Generation and Motorneuron Activation in a Simple Locomotory System @ Arizona State University |
1 |
1990 — 1992 |
Satterlie, Richard |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Human Physiology Laboratory: An Introduction to Scientific Inquiry @ Arizona State University
This award provides funds to the Department of Zoology at Arizona State University to purchase equipment which will help give freshman/sophomore-level, non-major students a laboratory experience involving scientific inquiry, critical thinking and evaluation skills, and student discovery using non-invasive human physiology experiments as a vehicle. The laboratory will use research-grade analogue recording equipment and transducers as well as computer-matched data acquisition equipment, and computer-based statistical and graphic data analysis software. The analogue equipment will be used for student-designed experiments while the computer-based transducers will be used for more organized laboratory exercises. Throughout the laboratory, emphasis will be placed on development of critical analysis of data, and an increase in general and specific scientific literacy rather than the "canned" experiment-memorization driven laboratory experiences typical of human physiology courses. In addition, the laboratory experience will be designed to give a specific introduction to human body function to include areas of current interest and of current misconception among college-age students.
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1 |
1991 — 1993 |
Satterlie, Richard A |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Peripheral Modulation of Swimming Speed @ Arizona State University-Tempe Campus
The proposed project involves an electrophysiological and ultrastructural investigation of modulation of swimming speed in the pteropod mollusc Clione limacina. Two peripheral modulatory inputs will be investigated, including a serotonergic pathway that enhances muscle activity without producing a direct motor response, and a direct input from motor neurons that are not directly influenced by the swim pattern generators. The role of these inputs in ballistic escape swimming will be investigated. Specifically, this investigation will include: (1) a description of the effects of serotonin perfusion on peripheral muscle cells, (2) description of activity of identified serotonergic neurons during locomotory speed changes including escape swimming, (3) description of the role of "startle" motor neurons in escape swimming, and (4) ultrastructural description of synaptic terminals of peripheral serotonin-immunoreactive neurons and startle motor neurons. Swim acceleration is accompanied by a distinct "change-of-gears" in Clione. Both central neuronal circuitry and peripheral muscle organization are arranged to produce two-geared speed changes. Since all neuron and muscle cell types of the swimming system are accessible for microelectrode recording, it is believed that the Clione swimming system is an excellent model system for investigation of the neurobiological bases of dramatic and subtle speed changes in a locomotory system. This information should be applicable to the study of gait changes in higher animals including humans. As such, the model may be useful to test the effects of specific and general perturbations on central, peripheral and modulatory subsystems within the overall Locomotory system. This project may also provide useful information for the fields of robotics and computer-generated muscle stimulation systems designed to produce walking movements in the limbs of paraplegics.
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0.958 |
1993 — 1994 |
Satterlie, Richard |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Symposium: Invertebrate Neuromuscular Organization: Peripheral Contributions to Behavioral Variability; December 27-30, 1993; Los Angeles, Ca @ Society For Integrative and Comparative Biology
ABSTRACT: 9314588, PI-Satterlie: This action is to provide travel costs for scientists to attend a special symposium at the Annual Meeting of The American Society of Zoologists on December 27 30, 1993. The symposium will consider invertebrate neuromuscular systems, and especially how variability in their cellular and developmental organization is reflected in behavior. This is an important topic that is important to both general and comparative neurobiology. The symposium will be important for synthesizing new data and suggesting new insights into how the brain controls movement. The lectures will be published in a special issue of the journal "American Zoologist". All of the scientists receiving support are American scientists, who will be speaking at the symposium and contributing papers to the final publication.
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0.918 |
1994 — 1998 |
Satterlie, Richard |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Role of Serotonin in Feeding Arousal in a Mollusc @ Arizona State University
9319927 Satterlie Behavioral arousal in animals and humans occurs when there is a change in several independent behaviors so that the overall behavioral output is more focussed or efficient. Behavioral arousal is an important issue that is not well-understood at the cellular level. In the marine mollusc Clione when prey is nearby, a feeding arousal response occurs in which there is a decreased threshold for starting the feeding behavior, an increase in swimming speed for more efficient prey capture, an increase in heart rate and an inhibition of the withdrawal response. This work will investigate the cellular mechanisms in the nervous system that give rise to this change in behavioral state and examine the role of the brain chemical serotonin in this behavior. Clione is an excellent animal in which to study behavioral arousal because the neural circuits that underlie the component behaviors (feeding, swimming, and withdrawal) have already been worked out and the level of individual nerve cells by the PI and others. The PI has also shown that injection of serotonin into the animal results in feeding arousal behavior and that there are cells in the Clione nervous system that contain serotonin. ***
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1 |
1999 — 2003 |
Satterlie, Richard |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Neural Control of Locomotory Speed Changes in a Mollusk @ Arizona State University
The proposed project involves an electrophysiological investigation of two types of locomotory speed changes in the pteropod mollusk Clione limacina. Clione exhibits both a dramatic speed change, analogous to a gait change in higher animals, and a more subtle speed change, equivalent to a change in speed within a single gait. Since the nervous system of Clione is relatively simple, we can investigate these speed changes at a level not allowed in higher animals. This model system should provide background information on the reorganization of central circuitry in rhythmic locomotory systems that allows increases in the frequency and strength of locomotory movements. We will use a variety of techniques, including electrophysiological recordings of identified neurons, force recordings from the locomotory musculature and immunohistochemical identification of neurons that release serotonin, a prime modulator that differentially triggers the two types of speed changes in Clione. Basic research of this type uncovers "rules" of how rhythmic behaviors are organized at the circuit and cellular levels, and how variability in these behaviors is achieved by various types of sensory inputs. These rules can be used in investigations of rhythmic behaviors in higher, more complex animals. In addition, investigation of simple model locomotory systems provides useful information for the fields of robotics and computer-assisted muscle stimulation in para- and quadriplegics.
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1 |
1999 — 2000 |
Satterlie, Richard |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Symposium: Swimming in Opisthobranch Mollusks: Contributions to Control of Motor Behavior, January 4 - 8, 2000, in Atlanta, Georgia @ Society For Integrative and Comparative Biology
Dr. Satterlie has organized a symposium that will be held in Atlanta, Georgia, January, 2000. The major scientists have been invited as speakers. This symposium will contribute to our understanding of the fundamental components of the nervous system required for rhythmic behaviors.
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0.918 |
2001 — 2003 |
Satterlie, Richard A |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Neural Control of a Ballistic Startle Response @ Arizona State University-Tempe Campus
The proposed project involves an electrophysiological investigation of the ballistic startle response in the pteropod mollusk Clione limacine. In the long term, we aim to describe both dramatic and subtle locomotory speed changes from the behavioral level to the level of membrane currents of component neurons and muscle cells. The Clione preparation is an excellent model system for examination of locomotory speed changes since a great deal is known about the swim circuitry and swim musculature, and since swimming shows both dramatic and subtle speed changes, in addition to ballistic escape swimming. The startle response/escape swimming is of interest for several reasons. The brief, ballistic startle response utilizes the same musculature as in normal swimming, however, the normal swim pattern generator, along with swim motoneurons are totally inhibited during the startle. In this project, we will examine the sensory activation of the startle, focusing on three newly identified tail mechanosensory neurons. In addition, the nature of the temporary inhibition between startle and swim systems will be described. Finally, we will examine mechanisms responsible for the immediate return to fast swimming at termination of the startle. The superimposition of startle responses on ongoing swimming activity is a problem faced by higher animals, including humans. The unique nature of the Clione startle system should provide insights into how two competing motor systems interact to produce appropriate hierarchical interactions that include temporary inhibition of locomotion by a startle reflex, and the immediate and smooth resumption of locomotion following the startle.
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0.958 |
2003 |
Satterlie, Richard |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Symposium: Recent Developments in Neurobiology, Toronto, Ontario, Canada On January 4-8, 2003 @ Society For Integrative and Comparative Biology
0245736 Satterlie RA
The Society for Integrative & Comparative Biology (SICB) emphasizes the comparative approach and multidisciplinary integration of cellular and molecular concepts into a functional framework involving the whole organism. The Division of Neurobiology is one of the youngest of the ten divisions of SICB; this symposium is its second annual program. The symposium highlights work from the local region near the meeting city, with a unique plan that pairs talks from a junior member with one from the laboratory head. This plan gives excellent experience and exposure with low cost to younger researchers in a small meeting. This year the talks are related to motor control, with five pairs of speakers, and the meeting in Toronto, Canada involves international participants. The topics are timely, on invertebrate and vertebrate systems, and the main speaker in each pair is widely recognized. Modest funding is for travel awards for participants. Dissemination of the SICB Symposia is through publication in the journal Integrative & Comparative Biology. The SICB meetings also have an impact on training and education by bringing in graduate and undergraduate students and postdocs for interdisciplinary interactions with established investigators.
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0.918 |
2004 — 2006 |
Dillaman, Richard Satterlie, Richard Keith, Julian (co-PI) [⬀] Kinsey, Stephen |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Acquisition of An Confocal Microscope @ University of North Carolina At Wilmington
This award provides support for purchase of a laser confocal scanning microsope (LSCM) to aid research and educational programs at the grantee institution. Confocal fluorescence microscopy, which allows the reconstruction of 3-D images of cells and tissues, has become one of the most important tools in contemporary cell science. The instrument will be placed in a central microscopy facility which is already well-equipped with electron and light microscopes, sample preparation equipment, and image analysis workstations. A faculty director and full-time microscopy technician provide training and support to faculty and student users of the facility. This microscope will be used for a diverse set of research programs, including 3-D reconstructions of neural networks in marine invertebrates, neurogenesis in the adult mammalian hippocampus, control of calcification in the crustacean cuticle, and metabolic organization of cells. The instrument will also be used in research training and education at all levels from undergraduate to postdoctoral, and will be available for use by researchers at other local and regional institutions.
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0.939 |
2004 — 2007 |
Satterlie, Richard |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Conference Symposium: Recent Developments in Neurobiology @ Society For Integrative and Comparative Biology
We will conduct an ongoing annual symposium entitled, "Recent Developments in Neurobiology (RDN)," to be presented at the annual meetings of the Society for Integrative and Comparative Biology (SICB). The RDN symposia uses a novel form of presentation-"piggy-back" talks, in which the head of the invited laboratory provides the first twenty-five minutes of a sixty-minute talk to discuss the general area of significance of the laboratory's research. The next twenty-five minute block is presented by a junior member of the laboratory, usually an advanced graduate student or post-doc, who gives specific information about the laboratory's current activities. The final ten minutes are devoted to a common question/answer period. The symposium papers will be published in the Society's journal, Integrative and Comparative Biology.
One of the goals of the "piggy-back" format is to provide experience to in-training members of the profession, in terms of symposium presentation/participation at a national meeting. Another is to expose these individuals, and their work, to potential employers. The symposium also seeks to provide a set of recent printed review papers to the Neuroscience community through the journal papers.
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0.918 |
2004 — 2005 |
Satterlie, Richard |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Symposium: Recent Developments in Neurobiology January 2004: New Orleans, La @ Society For Integrative and Comparative Biology
Society for Integrative and Comparative Biology Symposium: Recent Developments in Neurobiology January 4-8, 2004, New Orleans, LA
Goal of the symposium is to provide experience to in-training members of the profession, in terms of symposium presentation/participation at a national meeting. Another is to expose these individuals to potential employers. We also seek to provide a set of recent printed evaluations papers to the Neuroscience community through the journal papers.
We have included two advance assistant professors in the list of primary speakers, to break with the unwritten "rule" of extending exclusive invitations to more senior investigators. We choose to honor the productivity of these young faculties, and at the same time, contribute a symposium invitation to their upcoming tenure evaluations.
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0.918 |
2009 — 2012 |
Satterlie, Richard |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Expansion of the Seawater System of the Center For Marine Science @ University of North Carolina At Wilmington
The PI's request funding to expand and enhance seawater facilities by increasing wet laboratory space through expansion into an adjacent field equipment storage room on one side of the existing wet lab room, and into the former shipping/receiving room on the other side of the current wet lab room. These rooms were made available upon completion of the new wing of the CMS building. The original building included a wet laboratory and seawater facility for which demand has increased greatly due to new faculty hires and growth of research and education programs. The wet laboratory is supplied with seawater drawn from the ICW at the end of a pier. The CMS wet laboratory provides about 1,500 ft2 of space with 9 seawater access points to meet the needs of 68 UNCW faculty, their graduate and undergraduate students, and visiting investigators. With rapid development of marine research programs since 2000, demand for wet laboratory space has exceeded current availability. chambers to be available for specific project use (rather than dedication to a single project). Use priority of one of the chambers will go to graduate students working on dissertation or thesis research. Intellectual merit: Expansion of wet laboratory space would greatly increase the options for research and education available to UNCW faculty, visiting scientists and students at CMS. Expanded laboratory space would accommodate the growing demand for culture facilities for many research programs, the science cannot begin until organisms can be reliably and dependably maintained.
Broader Impacts:
The site is very active in education and research-training of undergraduate and graduate students. The additions will enhance capacity for student research and 1 environmental chamber has even been set aside for student work. The addition will also contribute to the many educational programs that the site hosts by providing animal holding facilities for hands-on and exploration programs. The center has been involved in outreach for over 20 years via a MarineQuest program offering primary and secondary students and adults hands on experiences (66,000 to date), and also through a variety of camps, classes, and seminars.
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0.939 |
2009 — 2014 |
Satterlie, Richard |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Neuromuscular Control of Directional Swimming in Cubomedusae @ University of North Carolina At Wilmington
Cubozoan jellyfish (box jellyfish) include some of the most venomous animals in the ocean, and their habitat includes nearshore areas in use for human recreation. Recent evidence suggests that two less venomous species of cubomedusae are invading local North Carolina waters in large numbers, just off of popular beaches. Furthermore, these jellyfish belong to an animal group, including corals and anemones, with the simplest and most primitive multicellular nervous systems. Despite this simplicity, these animals have very rich behavioral repertoires and can successfully avoid obstacles, swim toward dim light sources, and respond to brief shadows. These properties underline the importance of understanding the neural control of behavior in this very active group of jellyfish: to better understand how to adapt human recreational activity to the expanding habitat of these venomous animals and to gain insight into the evolution of nervous system function, in general, related to behavioral variability and muscular control. As voracious predators on small fish and crustaceans, their impact on commercially valuable species has yet to be evaluated. Finally, information on the neural control of behavior in cubomedusae may be useful in animal-inspired marine robotics that may be of use in both commercial and military applications. This project will use a combination of electrical recording from neurons and muscles, structural examination of neuromuscular organization, and behavioral observations to describe the rapid and accurate turning abilities in response to both visual and mechanical stimuli, and to describe the strong swimming abilities of the jellyfish.
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0.939 |