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High-probability grants
According to our matching algorithm, Edward R. Gruberg is the likely recipient of the following grants.
| Years |
Recipients |
Code |
Title / Keywords |
Matching
score |
| 1986 — 1993 |
Gruberg, Edward R |
R01Activity Code Description:
To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Studies On the Visual Inputs to the Optic Tectum
The principal objective of the proposed research is to study the physiology and effect on visually-related behavior, of a cholinergic feedback loop in a central visual processing area of the brain. The isthmo-tectal network in the midbrain of a lower vertebrate, the leopard frog, will be used as a model system. The specific aims are: 1) Explore the behavioral changes caused by unilateral and bilateral ablation of nucleus isthmi. 2) Block isthmo-tectal input to determine the effect of loss of n. isthmi input on tectal electrical activity. 3) Investigate the long term behavioral effects of ablation of n. isthmi alone and in conjunction with ablation to other brain structures to determine the extent of recovery of visual function. 4) Explore the behavioral consequences of tectal application of cholinergic antagonists. The long-term objective of this study is to determine how visual information is processed in the central nervous system in order to further our understanding of vision.
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1 |
| 1992 |
Gruberg, Edward R |
R01Activity Code Description:
To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Visual Inputs to the Optic Tectum
DESCRIPTION: (Investigator's Abstract) The proposed research will investigate the anatomy, physiology and effects on visually guided behavior of inputs from the retina and nucleus isthmi on a central visual processing area, the optic tectum. The isthmotectal network of the leopard frog will be used as a model vertebrate system. The specific aims are as follows: 1) To determine the retinal distribution of retinotectal ganglion cells after optic chiasm hemisections. Such hemisections spare visually guided prey catching and horseradish peroxidase histochemistry will be used to determine if there are regions of the tectum deafferented of retinal input. 2) To study possible behavioral and physiological changes after optic chiasm hemisection. Using both behavioral tests and single unit extracellular tectal recording, hemisected and matched controls will be compared. 3) To investigate changes in visually guided behavior after bilateral n. isthmi ablation. Animals will be tested to determine if visual deficits are global or primarily restricted to monocular visual fields. 4) To study the synaptic anatomy of horseradish peroxidase labeled isthmotectal and tectoisthmal axons. Electron microscopy will be used to determine the elements that are in synaptic contact with terminals of these axons. The long term objective of this study is to determine how visual information is processed in the central nervous system in order to further our understanding of vision.
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1 |