Area:
Neuroscience Biology
We are testing a new system for linking grants to scientists.
The funding information displayed below comes from the
NIH Research Portfolio Online Reporting Tools and the
NSF Award Database.
The grant data on this page is limited to grants awarded in the United States and is thus partial. It can nonetheless be used to understand how funding patterns influence mentorship networks and vice-versa, which has deep implications on how research is done.
You can help! If you notice any innacuracies, please
sign in and mark grants as correct or incorrect matches.
Sign in to see low-probability grants and correct any errors in linkage between grants and researchers.
High-probability grants
According to our matching algorithm, Joseph M. Breier is the likely recipient of the following grants.
| Years |
Recipients |
Code |
Title / Keywords |
Matching
score |
| 2003 — 2005 |
Breier, Joseph M |
F31Activity Code Description:
To provide predoctoral individuals with supervised research training in specified health and health-related areas leading toward the research degree (e.g., Ph.D.). |
Mdma Neurotoxicity and 5ht-Glutamate Interactions @ Boston University Medical Campus
DESCRIPTION (provided by applicant): Given the current rise in abuse of 3,4-methylenedioxymethamphetamine (MDMA), understanding the mechanisms and long-term consequences of the selective serotonin (5HT) neurotoxicity that results from its abuse is critical. The overall objective is to provide insight into the effects of MDMA-mediated 5HT neurotoxicity. Specifically, the proposed experiments will examine the altered ability of 5HT to modulate glutamate transmission in the hippocampus. Previous work has shown that high doses of MDMA decrease neuronal markers of 5HT transmission in the hippocampus, but has stopped short of delineating the neurochemical consequences of this 5HT neurotoxicity. This research proposal will involve training in dual probe in vivo microdialysis and HPLC-EC. Specific Aim 1 will determine the ability of MDMA-induced 5HT neurotoxicity to augment glutamate transmission in the hippocampus through disinhibition mediated by a decrease in 5HT transmission in the hippocampus and increased autoinhibition in the dorsal raphe nucleus (DRN). Since the hippocampus is vulnerable to damage produced by stress, Specific Aim 2 will examine the potential for MDMA-induced 5HT neurotoxicity to synergize with acute and chronic stress to further augment hippocampal glutamate transmission and to promote glutamate-mediated excitotoxicity. The proposed studies will elucidate some of the long-term functional consequences of MDMA-induced 5HT neurotoxicity that may occur in MDMA abusers and begin to address the neural mechanisms that may explain the variety of reported memory deficits evident in MDMA abusers.
|
1 |