Area:
Epilepsy, pathophysiology
We are testing a new system for linking grants to scientists.
The funding information displayed below comes from the
NIH Research Portfolio Online Reporting Tools and the
NSF Award Database.
The grant data on this page is limited to grants awarded in the United States and is thus partial. It can nonetheless be used to understand how funding patterns influence mentorship networks and vice-versa, which has deep implications on how research is done.
You can help! If you notice any innacuracies, please
sign in and mark grants as correct or incorrect matches.
Sign in to see low-probability grants and correct any errors in linkage between grants and researchers.
High-probability grants
According to our matching algorithm, Kevin D. Graber is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
2000 — 2002 |
Graber, Kevin D |
K08Activity Code Description: To provide the opportunity for promising medical scientists with demonstrated aptitude to develop into independent investigators, or for faculty members to pursue research aspects of categorical areas applicable to the awarding unit, and aid in filling the academic faculty gap in these shortage areas within health profession's institutions of the country. |
Prevention of Posttraumatic Neocortical Epileptogenesis
DESCRIPTION (Adapted From The Applicant's Abstract): Epilepsy following head trauma often appears after a quiescent period of months or years. In the rat "undercut" model of posttraumatic epileptogenesis, tetrodotoxin (TTX) treatment will prevent epileptogenesis, allowing comparison of epileptogenic and nonepileptogenic injured neocortex. More information about changes in cortical circuitry and changes in receptor fimction following epileptogenic injuries is fundamental to progress in developing prophylaxis or new treatments suitable for humans. This project focuses on the function and critical role of ionotropic glutamatergic receptor-mediated excitation in the undercut model. Patch clamp techniques will be used to evaluate miniature, spontaneous and evoked excitatory currents and unitary responses of synaptically coupled pairs of pyramidal neurons in epileptogenic and nonepileptogenic injured neocortical slices from rats several weeks following surgical cortical isolations. Each of these indices will be quantified to provide complementary information about the state of functional excitation in chronically epileptogenic cortex. The project will be carried out in the fully equipped and well supported epilepsy research laboratory of the Department of Neurology and Neurological Sciences at Stanford University. The sponsor has trained numerous students and fellows, many of whom are now prominent in the field of neurophysiology and epilepsy. An outstanding neuroscience faculty, a critical mass of postdoctoral fellows in the Stanford Epilepsy Training Program, numerous seminars and courses are available to enrich and supplement the laboratory training. This fellowship is an important step in the acquisition of technical acumen and research experience that will be crucial in developing a successful academic career as a clinician/scientist and independent investigator in epilepsy.
|
1 |
2004 — 2005 |
Graber, Kevin D |
K08Activity Code Description: To provide the opportunity for promising medical scientists with demonstrated aptitude to develop into independent investigators, or for faculty members to pursue research aspects of categorical areas applicable to the awarding unit, and aid in filling the academic faculty gap in these shortage areas within health profession's institutions of the country. |
Prevention of Postraumatic Neocortical Epileptogenesis
DESCRIPTION (provided by applicant): Epilepsy following head trauma often appears after a quiescent period of months or years. In the rat "undercut" model of posttraumatic epileptogenesis, tetrodotoxin (TTX) treatment will prevent epileptogenesis, allowing comparison of epileptogenic and non-epileptogenic injured neocortex. More information about changes in cortical circuitry following epileptogenic injuries is fundamental to progress in developing prophylaxis or new treatments suitable for humans. This project focuses on the function and critical role of inhibition and excitatory coupling in the undercut model. Patch clamp techniques will be used to evaluate miniature, spontaneous and evoked inhibitory currents in pyramidal neurons in epileptogenic and non-epileptogenic injured neocortical slices from rats several weeks following surgical cortical isolations. Excitatory synaptic coupling will be investigated using laser uncaging of caged glutamate, to map topographic fields of inputs. Also, expression of numerous mRNAs in these tissues will be examined using Affymetrix Rat Genome microarrays, to better understand the TTX effect and identify new potential targets for preventing and curing epilepsy. Candidate antiepileptic genes will be further characterized with Q-PCR experiments, and corresponding proteins investigated with immunocytochemistry and western blot. Investigations will occur in a fully equipped and well-supported epilepsy research laboratory of the Department of Neurology and Neurological Sciences at Stanford University. The sponsor has trained numerous students and fellows, many of whom are now prominent in the field of neurophysiology and epilepsy. A new co-mentor within the department, also with extensive resources and experience, will advise molecular and genomic studies. An outstanding neuroscience faculty, a critical mass of post-doctoral fellows in the Stanford Epilepsy Training Program, numerous seminars and courses are available to enrich and supplement the laboratory training. Extension of the award period will allow acquisition of additional techniques in molecular biology and research experience and allow needed time to complete and publish projects, dramatically improving the likelihood of success in an academic career as a clinician/scientist and independent investigator in epilepsy.
|
1 |