Area:
Synaptic Physiology, Fragile X, Parkinsons
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High-probability grants
According to our matching algorithm, Jesse E. Hanson is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
2001 — 2002 |
Hanson, Jesse E |
F31Activity Code Description: To provide predoctoral individuals with supervised research training in specified health and health-related areas leading toward the research degree (e.g., Ph.D.). |
Basal Ganglia Function: Globus Pallidus Neurons
The overall objective of this work is to understand the function of the basal ganglia in both the normal and diseased states. Pathology of the basal ganglia leads to several mental health disorders including dementias due to Parkinson's and Huntington's Disease as well as Obsessive Compulsive Disorder and Tourette's Syndrome. However, little is known about the precise function of the basal ganglia circuit must be formed. The goal of this project is to understand how neurons in the Globus Pallidus (GP), a nucleus in the basal ganglia, process inputs. By understanding how the intrinsic properties these neurons interact with thousands of synaptic inputs to form a single output spike train, sight into the function of this stage of the basal ganglia circuit may be obtained. Specifically the distribution of intrinsic conductances will be examined using antibody labeling observed with electron microscopy. A compartmental model of single neurons will be made incorporating this information. This model will be used to probe the input-output function of GP neurons. The insight gained from this model will be related to real neurons by testing predictions of the model in living neurons, using in vitro electrophysiological recordings with simulated synaptic inputs. This approach of integrating information from experimental measurements and model simulations will provide a description of how these neurons process inputs. The knowledge gained by this study will provide an important piece of the puzzle in the effort to understand normal and diseased function of the basal ganglia.
|
0.966 |
2004 — 2006 |
Hanson, Jesse E |
F32Activity Code Description: To provide postdoctoral research training to individuals to broaden their scientific background and extend their potential for research in specified health-related areas. |
Transitions Between Synaptic States in the Hippocampus
[unreadable] DESCRIPTION (provided by applicant): The overall objectives of this proposal are to understand the mechanisms of long-term synaptic plasticity. Long-term synaptic plasticity is widely believed to underlie learning and memory, and understanding the mechanisms of this plasticity will yield insight into the normal development and function of the brain as well as the pathology resulting from a wide range of neurological diseases. This proposal will utilize the technique of recording from individual pairs of synaptically connected neurons. This approach allows much better resolution of the different plastic states a synapse may exhibit than is afforded by many previous studies of plasticity that are based on summed measurements of many synaptic connections. Specifically, we will examine how the state of a synapse and the history of states a synapse has visited influence its potential to exhibit plasticity. We will determine if there are differences in the ability of synapse to be potentiated based on its history of being in active or silent states. We will also examine how different glutamate receptor components of the synaptic response are changed during potentiation of synapses that start in different states [unreadable] [unreadable]
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