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High-probability grants
According to our matching algorithm, Brian Levine is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
2002 — 2006 |
Levine, Brian T |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
The Neuroanatomy of Cognition in Traumatic Brain Injury @ Rotman Research Institute
DESCRIPTION (provided by applicant) Traumatic brain injury (TBI) is the most common cause of disability in young adults. While much of this disablement is attributable to mental difficulties, the brain mechanisms underlying these difficulties are poorly understood. There is tremendous variability in TBI effects even among patients with similar injury characteristics. This wide range of behavioral outcomes implies variability in neural reorganization supporting these mental operations. We will explore the neural correlates of mental functioning following TBI with functional magnetic resonance imaging (fMRI), a technique for studying dynamic brain function (i.e., functional neuroanatomy). Our focus is on executive functioning and memory, the primary cognitive deficits affecting real-life adjustment following TBI. The activation tasks will include two measures of response inhibition and three measures of memory. The functional neuroanatomy of response inhibition will also be examined pre- and post-rehabilitation using a training program that targets executive deficits. Each experiment capitalizes on an established paradigm from our previous behavioral research with brain-injured patients or our functional neuroimaging research with healthy adults. In addition to standard image analysis techniques emphasizing local brain activations, we will employ multivariate techniques that stress functional interactions across the brain. These techniques are necessary to characterize the task- and performance-related chances in brain connectivity fundamental to the neuropathology of TBI. These studies should impact the direct care of patients with TBI through the development of diagnostic imaging techniques that can be used to characterize brain-behavior relationships and assess functional neuroanatomical changes due to natural recovery and rehabilitation. Moreover, we expect these findings to increase the understanding of neural changes (i.e., neural compensation or re-organization) in response to brain injury in general.
|
0.958 |
2007 — 2009 |
Levine, Brian T |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Memory and Attention in People Who Experienced a Single Life-Threatening Event @ Rotman Research Institute
[unreadable] DESCRIPTION (provided by applicant): Memory and attentional processes are commonly affected by trauma, yet their neural and behavioral correlates in relation to trauma are poorly understood. The proposed research capitalizes our access to a group of individuals who shared experience of a single traumatic event, allowing us to examine the effects of this event and individual differences in response to this event with an unusual amount of experimental control. Our studies will examine how emotional trauma attendant to near loss of life changes memory and attention, and the relationship of these of changes to other key variables, such as the presence of post-traumatic stress disorder (PTSD). A central question in PTSD concerns the fact that some individuals develop the disorder whereas others do not in response to the same traumatic event. The proposed research will address this issue eliminating variance due to the event itself and by using extensive neurobehavioral, psychiatric, and neuroimaging data to systematically examine variables that dissociate PTSD and non-PTSD groups. Moreover, using well-validated measures of autobiographical memory and attention developed in our laboratory, we plan to examine the behavioral correlates of altered attentional and memory function in these groups. Additional studies will address the functional neuroanatomy of autobiographical memory and attention in participants with and without PTSD and controls using measures sensitive to emotional influences on these processes. Understanding the neural and behavioral correlates of memory and attentional processing following trauma at a more basic level is likely to yield benefits in increased scientific knowledge, and also translate to improvements in the design of treatment interventions focusing on these processes and their altered functioning. RELEVANCE TO PUBLIC HEALTH: The mental and behavioral consequences of trauma affect scores of North Americans, yet the mechanisms of these effects, including the development of post-traumatic stress disorder (PTSD) are poorly understood. These projects will explore the effects of trauma on brain functioning and behavior using a sample of individuals who nearly lost their lives in an airline disaster, allowing a unique opportunity to study the effects of trauma in people who experienced the same event. [unreadable] [unreadable] [unreadable]
|
0.958 |