1985 — 2000 |
Bloedel, James R |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Neuronal Integration in Cerebellar Systems @ St. Joseph's Hosp/Med Ctr (Phoenix)
The objectives of these experiments are twofold. Firt, studies will be performed to examine mechanisms by which information is processed in the cerebellar cortex. Specifically, the changes in the temporal patterning of Purkinje cell spikes resulting from the activation of cerebellar afferent pathways will be evaluated. Particular emphasis will be placed on determining the extent to which the patterning of simple spikes produced by the action of climbing fibers contributes to the responsiveness of Purkinje cells to mossy fiber inputs. Second, a separate series of studies will examine the action of dentato-bulbospinal pathways on segmental reflexes. The effects of activating this system on the stretch reflex and the cutaneomuscular reflexes will be assessed.
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1 |
1986 |
Bloedel, James R |
R24Activity Code Description: Undocumented code - click on the grant title for more information. |
Facilities Improvement For Animal Care and Storage @ St. Joseph's Hosp/Med Ctr (Phoenix)
The purpose of this proposal is to obtain cagewashing equipment and animal cages required to upgrade the animal Vivarium at the Barrow Neurological Institute. The Administration of the Institute and the Hospital with which it is associated, St. Joseph's Hospital and Medical Center, has recently committed $320,525 for the renovation of the existing Vivarium space and a significant expansion of the facility. However, the appropriate and optimal utilization of this upgraded physical facility also requires the acquisition of cages for animal housing to replace existing outdated cages and to provide new housing for the added space. In addition, the present cagewashing facility is very old and unreliable and therefore must be replaced. The Vivarium of the Barrow Neurological Institute continues to be an FDA and AAALAC approved facility. It is our intent to upgrade our present facility in a manner consistent with the guidelines of these agencies so that an excellent level of animal care can continue to be delivered in association with the recently expanded research and teaching programs of the Institute.
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0.901 |
1987 — 1991 |
Bloedel, James R |
S07Activity Code Description: To strengthen, balance, and stabilize Public Health Service supported biomedical and behavioral research programs at qualifying institutions through flexible funds, awarded on a formula basis, that permit grantee institutions to respond quickly and effectively to emerging needs and opportunities, to enhance creativity and innovation, to support pilot studies, and to improve research resources, both physical and human. |
Biomedical Research Support Grant @ St. Joseph's Hosp/Med Ctr (Phoenix)
Funds are requested for purchase of a VG Autospec three-sector double- focusing mass spectrometer equipped with chromatograph and interface, extended mass range, and interchangeable electron-ionization, chemical- ionization, normal and continuous-flow fast-atom bombardment, and field desorption ion sources. The instrument is needed for two purposes. First, it will replace a 10-year old Kratos MS-30 instrument of 20-year old design as one of the only two campus-wide double-focusing mass spectrometers currently providing accurate-mass or fast-atom bombardment (FAB) mass spectra of 3,000 samples per year for OSU researchers. Second apart form its technical performance superiority, the new instrument is vastly simpler to operate and service, and should this significantly improve our mass spectrometry service productivity and reliability. Third, the instrument will provide several important new mass spectrometric capabilities not currently available at Ohio State: continuous-flow FAB, field desorption, and accurate-mass thermospray LC/MS, as well as higher sensitivity (factor of 10 in both EI and FAB), higher mass resolution (60,000 vs.40,000), much higher upper mass limit (4,500 vs. 2,000 u at all full accelerating voltage), and an improved data system compared to our other double-focusing instrument (VG 70-250S). The instrument will be operated an maintained by the permanent staff of the Ohio State University Campus Chemical Instrument Center, which includes three full-time permanent staff mass spectrometrists and an electrical engineer (please see enclosed descriptive brochure), and will be made available campus-wide to all members of the OSU biochemical research community. The NIH-supported "Core Group" of researchers listed below, with a combined annual NIH operating support of more than $2.5 million, currently accounts for more than 80% of the present usage (2,500 samples per year) of our two existing double-focusing instruments .
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0.901 |
1988 — 1990 |
Bloedel, James R |
S15Activity Code Description: Undocumented code - click on the grant title for more information. |
Small Instrumentation Program @ St. Joseph's Hosp/Med Ctr (Phoenix)
biomedical equipment resource; biomedical equipment purchase;
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0.901 |
1992 — 1996 |
Bloedel, James R |
P01Activity Code Description: For the support of a broadly based, multidisciplinary, often long-term research program which has a specific major objective or a basic theme. A program project generally involves the organized efforts of relatively large groups, members of which are conducting research projects designed to elucidate the various aspects or components of this objective. Each research project is usually under the leadership of an established investigator. The grant can provide support for certain basic resources used by these groups in the program, including clinical components, the sharing of which facilitates the total research effort. A program project is directed toward a range of problems having a central research focus, in contrast to the usually narrower thrust of the traditional research project. Each project supported through this mechanism should contribute or be directly related to the common theme of the total research effort. These scientifically meritorious projects should demonstrate an essential element of unity and interdependence, i.e., a system of research activities and projects directed toward a well-defined research program goal. |
Modification and Control of Motor System Function @ St. Joseph's Hosp/Med Ctr (Phoenix)
The purpose of this Program Project is to conduct a series of collaborative research projects focused on its theme, "Modification and Control of Motor System Function". The Program Project contains four research proposals and four cores to address this objective. Proposals 1 and 2 utilize a newly-developed multiple single-unit recording technique that permits the simultaneous recording of eight to twelve neurons in specific central nuclei during the acquisition of various types of conditioned behavior. Proposal I focuses on the neural substrates of the classical conditioned nictitating membrane response in the rabbit. The experiments in Proposal 2 examine the role of cerebellar systems in the acquisition of two types of conditioned behavior: a conditioned modification of locomotion and an operantly-conditioned reaching behavior in chronic cats. Proposal 3 also focuses on cerebellar and brainstem systems, specifically addressing the behavioral modification of cat inferior olivary responses during the execution of specific motor behaviors. The functional characteristics of spinal reflex systems is addressed in Proposal 4. These experiments examine the segmental and supraspinal control of the foot and ankle. These projects bring together a highly interactive faculty who will share their expertise to address these research objectives in a very comprehensive manner. It is expected that the results from the proposed studies not only will provide substantial insight into the way specific components of the motor system contribute to task acquisition and motor performance, but also will reveal intriguing insights into the changes in neuronal population responses during motor learning, the characteristics of gating mechanisms occurring during motor behavior, and the interaction between descending systems and segmental spinal reflexes related to the hindlimb. The Program Project is organized in a manner that optimizes the growth of the interactions among the participating faculty and the quality of their research programs. It will be administered in an environment that is highly dedicated to training in the clinical and basic sciences and will serve as a focus for formal and informal interfaces with other divisions in the Institute and the regional academic and scientific community.
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0.901 |
1992 |
Bloedel, James R |
S15Activity Code Description: Undocumented code - click on the grant title for more information. |
Small Instrumentation Grant @ St. Joseph's Hosp/Med Ctr (Phoenix)
biomedical equipment purchase;
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0.901 |
1998 — 2002 |
Bloedel, James R |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Cerebellar Contribution to Adaptive Reaching Behaviors
DESCRIPTION (from applicant's abstract) The experiments proposed in this grant request are designed to examine the role of the cerebellum in the learning of two different cerebellar-dependent adaptive reaching movements, one to compensate for image displacing prisms and the other to compensate for the application of an elastic load capable of displacing the limb from its intended trajectory. The experiments assess the general hypothesis that the cerebellum's role in the learning of motor tasks is highly task-dependent. In the first group of experiments, the contribution of the cerebellum to prism adaptation will be explored in human subjects and in cats trained to reach for a manipulandum while wearing image displacing prisms. Our preliminary data indicate that this compensatory process is dependent on the cerebellum, but in a different manner than currently believed. In a second group of studies, human subjects and cats will be required to adapt to the application of an elastic load applied during a reaching movement. Preliminary studies indicate that this adaptation employs a response to the perturbation that is highly dependent upon on-line processing by the cerebellum. The experiments will determine the capacity of cerebellar patients and cats with inactivated ipsilateral interposed and dentate nuclei to acquire and retain these two types of adaptive behaviors. The cerebellar-dependent features of the adaptation acquired normally will be contrasted with those governing adaptation when the cerebellum is dysfunctional. The cat paradigms will be used to asses the neuronal interactions occurring in the cerebellum underlying the acquisition as well as the execution of these two types of adaptive behaviors. Multiple single unit recording in functionally related regions of the cerebellar cortex and nuclei will elucidate the neuronal interactions within a specific sagittal zone during both the acquisition and performance of these adaptive behaviors, emphasizing those interactions related to the cerebellar-dependent features of the learning process. The findings will reveal important principles related to the learning of motor behaviors, the basis for certain functional abnormalities in cerebellar patients, and general mechanisms which may be invoked during recovery of motor function following ablative pathology in the central nervous system.
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1 |
2002 |
Bloedel, James R |
S07Activity Code Description: To strengthen, balance, and stabilize Public Health Service supported biomedical and behavioral research programs at qualifying institutions through flexible funds, awarded on a formula basis, that permit grantee institutions to respond quickly and effectively to emerging needs and opportunities, to enhance creativity and innovation, to support pilot studies, and to improve research resources, both physical and human. |
Web Based System For Efficient and Thorough Irb Review
The purpose of this project is to design and implement an electronic routing and database system that will improve the efficiency of the human subjects review process through: 1) making the application process more user-friendly for the investigator(s); 2) encouraging a more thorough review by the Institutional Review Board (IRB) members while shortening the turn around time; 3) improving the communication between the investigator(s) and the IRB; 4) providing additional security for the compliance review process, data storage and retrieval; 5) eliminating as much as possible the "human error" from the approval process by automating the submission, notification of approval, continuing review, project closure and review of the prerequisites before research accounts are opened; 6) providing additional education opportunities for the investigators, key personnel and support staff, 7) creating programs to evaluate the human subjects protection programs and link the compliance review process to administrative processes in the Office of Sponsored Programs Administration. The proposed system will have a web-based interface to a database that resides on a secure server. Communication throughout the process will be through this interface, e-mails, and, where regulated and necessary, through hard copies. This system will consist of the following modules: 1) principal investigator submission of the proposal/protocol; 2) scientific review; 3) IRB review; 4) modification; 5) continuing review and closure of a project; and 6) education of investigators and IRB members. Special attention is paid to system security, linkage with other administrative databases on campus, and assessment.
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