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High-probability grants
According to our matching algorithm, Philip E. Lloyd is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
1986 — 1988 |
Lloyd, Philip E |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Modulatory Neuropeptides
The long range goal of this research is to gain insight into mechanisms underlying the modulation of synaptic transmission. The relatively simple nervous system of Aplysia has advantages that have made it particularly useful for these studies. The specific aim of this grant is to explore the hypothesis that neuropeptides which are present in motor neurons are released during stimulation to modulate the effectiveness of conventional excitatory transmitters released from the same neurons. This will be investigated in a model system comprised of identifiable motor neurons which innervate feeding muscles and synthesize and contain characterized neuropeptides in addition to conventional excitatory transmitters such as acetylcholine. The neuropeptides have been shown to be potent modulators of neuromuscular transmission at feeding muscles. Different motor neurons contain different modulatory neuropeptides so it will be possible to determine if the peptides in a particular neuron "tailor" the plastic properties of neuromuscular transmission to individual muscles. There is a possibility that understanding fundamental neural processes such as modulation of synaptic transmission in Aplysia could have relevance to disorders of movement as well as more general disorders of affect and cognition.
|
1 |
1989 — 2000 |
Lloyd, Philip |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Modulatory Neuropeptides in Aplysia
IBN 9728453 LLOYD The long range goal of this research is to gain insight into mechanisms underlying the modulation of synaptic transmission, that is modifications in the way one nerve cell (neuron) in the nervous system communicates with another, through release of chemical signaling molecules. It is now clear that many neurons contain more than one transmitter and it is important to determine how multiple transmitters released from the terminals (endings) of single neurons interact on presynaptic and postsynaptic targets. Specifically, neuropeptide transmitters (polypeptides serving as transmitters) appear to commonly coexist along with conventional transmitters (such as acetyl choline). The relatively simple nervous system of Aplysia (the "sea hare," a marine mollusc) has a number of advantages that make it particularly useful as a model system for these studies. One goal of this grant is to explore the manner in which neuropeptides that are released from motor neurons (neurons innervating muscle) interact to modulate the effectiveness of other transmitters released from the same neuron. A second goal is to investigate the effects of a "biogenic amine", serotonin, released from purely modulatory neurons which have neuromuscular terminals. The neuropeptides and serotonin have been shown to be potent modulators of neuromuscular transmission. These studies have implications for vertebrate skeletal neuromuscular junctions where peptide cotransmitters have also been found. Understanding fundamental neural processes such as the modulation of synaptic transmission at these neuromuscular synapses could provide a more general understanding of synapses which release multiple transmitters as well as have relevance to disorders of movement.
|
1 |
1998 — 2002 |
Lloyd, Philip E |
T32Activity Code Description: To enable institutions to make National Research Service Awards to individuals selected by them for predoctoral and postdoctoral research training in specified shortage areas. |
Training in Neural Systems |
1 |