Area:
Molecular Biology, Oncology, Cell Biology
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High-probability grants
According to our matching algorithm, Thomas Kadesch is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
1995 — 2002 |
Kadesch, Thomas |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Transcriptional Determinants of B Lymphocytes @ University of Pennsylvania
DESCRIPTION (Adapted from Investigator's abstract): The long term goal of this work is to understand the transcriptional mechanisms that underlie B lymphocyte identity. Specifically, the investigator will characterize the E2A proteins (E12 and E47) by identifying the cause of their activation in B cells and by exploring the consequences of that activation. Initially identified as Ig enhancer-binding proteins, the E2A proteins are known to be necessary for early B cell development and, hence, must be important for activating additional genes. Activity of the E2A proteins is regulated. For example protein is present in a wide variety of cells, but the ability to bind DNA as homodimers is B-cell specific. The PI's group has shown that regulation of DNA binding is a consequence of cell-specific phosphorylation and that DNA binding is not the only regulated target. There are four specific aims: 1) to continue their analysis of E47 phosphorylation, 2) to elucidate the mechanism of E47 activation by Ras, 3) to identify novel proteins that interact with E47 functionally or physically and 4) to identify novel E47-induced genes.
|
1 |
1998 — 2002 |
Kadesch, Thomas |
P01Activity Code Description: For the support of a broadly based, multidisciplinary, often long-term research program which has a specific major objective or a basic theme. A program project generally involves the organized efforts of relatively large groups, members of which are conducting research projects designed to elucidate the various aspects or components of this objective. Each research project is usually under the leadership of an established investigator. The grant can provide support for certain basic resources used by these groups in the program, including clinical components, the sharing of which facilitates the total research effort. A program project is directed toward a range of problems having a central research focus, in contrast to the usually narrower thrust of the traditional research project. Each project supported through this mechanism should contribute or be directly related to the common theme of the total research effort. These scientifically meritorious projects should demonstrate an essential element of unity and interdependence, i.e., a system of research activities and projects directed toward a well-defined research program goal. |
Role of the E2a Bhlh Proteins in B Lymphocyte Commitment @ University of Pennsylvania
DNA binding protein; gene expression; B lymphocyte; chimeric proteins; immunogenetics; cell differentiation; cell line; laboratory mouse; transfection;
|
1 |
1999 — 2002 |
Kadesch, Thomas |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Notch Signaling in Hematopoietic Cells @ University of Pennsylvania
DESCRIPTION (Adapted from Investigator's Abstract): This resubmission focuses on signaling by Notch, a transmembrane receptor that influences cell fate choices in lower eukaryotes and which can alter proper development of particular cell lineages in higher eukaryotes, including T lymphocytes. The proposed experiments stem from the investigator's observation that Notch signaling can inhibit E47, a transcription factor that plays a critical role in early B cell development. He proposes, by extension, that Notch may also influence B cell development. The proposal takes a broad view and attempts to understand Notch from the phenotypic consequences of its activation to its molecular mechanisms of action. A combination of cell culture systems and transgenic mice will be used to investigate the effects of Notch signaling on gene expression in and development of B cells. Transgenic mice harboring a Notch responsive reporter will be generated in order to identify particular cells in the developing embryo and the adult that undergo Notch signaling. These latter experiments may provide insights into the mechanisms that govern cell fate decisions in a variety of cell developmental contexts. Finally, experiments are proposed to elucidate the molecular details of Notch's activation of the transcription factor CBF1. Recent results have shown that Notch inhibition of E47 does not involve signaling to CBF1 and, instead, may involve a novel pathway involving a second Notch-interacting protein called Deltex. Experiments are proposed to characterize signaling through Deltex.
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1 |