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High-probability grants
According to our matching algorithm, Richard E. Keesey is the likely recipient of the following grants.
| Years |
Recipients |
Code |
Title / Keywords |
Matching
score |
| 1985 — 1990 |
Keesey, Richard E |
R01Activity Code Description:
To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Physiological Regulation of Body Weight @ University of Wisconsin Madison
The aim of this project is to develop animal models appropriate for studing the physiological mechanisms associated with the condition of stable weight maintenance at different levels. To study weight maintenance at elevated or obese levels, we propose to use 1) the genetically obese Zucker rat, 2) the ventromedial hypothalamic lesioned rat, and 3) the dietary obese rat. As a model of weight maintenance at reduced levels we will use the lateral hypothalamic lesioned rat. By studying these preparations, we hope 1) to gain a better understanding of how energy balance is achieved at widely different levels, 2) to establish criteria by which we can judge whether or not the maintained energy levels in different preparations result from abnormally high or low "set-points" or from regulatory failure, 3) to examine the adjustments in whole body metabolism that serve to maintain the regulated or "set-point" level of body energy, 4) to explore the role of the autonomic nervous system in setting the weight levels at which normal energy balance is reached, 5) to use parasympathetic and sympathetic manipulations to establish lower or higher regulation levels, and 6) to normalize "set-points" using such autonomic manipulations in rats which regulate body weight at elevated or reduced levels. An understanding of these processes and the identification of their features should have direct application to the diagnosis and treatment of weight disorders in humans.
|
1 |
| 1993 — 1998 |
Keesey, Richard E |
R01Activity Code Description:
To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Physiological Regulation of Body Weight and Composition @ University of Wisconsin Madison
A series of experiments is proposed to characterize the lateral hypothalamic (LH) lesion induced reduction in the body protein and lipid tissue masses. The specific tissues sacrificed in reducing body protein, and the role growth hormone may play in these changes will be assessed. The possibility that altered capacities for fat oxidation contribute to lesion-induced body lipid changes will also be examined. In a final series of experiments, the activity of brown adipose tissue and the norepinephrine turnover rate in visceral tissues will be used to assess lesion-induced changes in sympathetic nervous system activity during the acute hypermetabolic phase and during the chronic stage of stable, but reduced, body mass.
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1 |