Area:
Molecular Biology, Oncology
We are testing a new system for linking grants to scientists.
The funding information displayed below comes from the
NIH Research Portfolio Online Reporting Tools and the
NSF Award Database.
The grant data on this page is limited to grants awarded in the United States and is thus partial. It can nonetheless be used to understand how funding patterns influence mentorship networks and vice-versa, which has deep implications on how research is done.
You can help! If you notice any innacuracies, please
sign in and mark grants as correct or incorrect matches.
Sign in to see low-probability grants and correct any errors in linkage between grants and researchers.
High-probability grants
According to our matching algorithm, Khanh D. Huynh is the likely recipient of the following grants.
| Years |
Recipients |
Code |
Title / Keywords |
Matching
score |
| 2005 — 2009 |
Huynh, Khanh D |
K01Activity Code Description:
For support of a scientist, committed to research, in need of both advanced research training and additional experience. |
The Role of X-Linked Gene Expression in Mammary Tumorigenesis @ Massachusetts General Hospital
DESCRIPTION (provided by applicant): In female mammals, one of the two X-chromosomes is transcriptionally silenced through an epigenetic process known as X-chromosome inactivation (XCI). This dosage compensation mechanism ensures equal X-linked gene expression between XX females and XY males, and is necessary for normal development. A large body of experimental observations over the past several decades has implicated a role for XCI mis-regulation in the development and pathogenesis of various cancers, particularly female breast and reproductive cancers. First, loss of the Barr body -- a cytological signature of an inactivated X-chromosome -- has often been described for many female tumors. Second, X-chromosome anomalies, most often characterized by the gain of one or more transcriptionally active X-chromosomes and/or reactivation of the inactive X is a common phenomenon observed in many tumor cells. Third, the tumor suppressor, BRCA1, implicated in familial breast and ovarian cancers, has a role in X-chromosome inactivation. The objective of the proposed study is to investigate the role of X-chromosome reactivation in breast tumorigenesis. The long-term goal is to elucidate the role of X-linked genes in tumor development and pathogenesis. The specific aims are: 1) to determine the role of ectopic X-linked expression in breast tumorigenesis using a mouse model system; 2) to identify and characterize X-linked genes overexpressed in breast tumors.
|
1 |